Category: 614-16-4

Related Products of 614-16-4In 2019 ,《Electrostatic potential dispersing pyrimidine-5-carbonitrile acceptor for high efficiency and long lifetime thermally activated delayed fluorescence organic light-emitting diodes》 appeared in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. The author of the article were Jang, Ji Seon; Lee, Ha Lim; Lee, Kyung Hyung; Lee, Jun Yeob. The article conveys some information:

Pyrimidine-5-carbonitrile was developed as an electrostatic potential managing and strong acceptor moiety of thermally activated delayed fluorescence (TADF) emitters for high efficiency and long lifetime in devices. Two types of TADF emitters with the donor moiety extended from either the 2 or 4 position of the acceptor moiety were prepared to study the effect of the donor substitution position on the TADF characteristics of the TADF emitters. Comparison of the two types of TADF emitters suggested that the extension of the donor structure from the 4 position of the pyrimidine-5-carbonitrile acceptor is an effective way of enhancing the external quantum efficiency (EQE) and lifetime of the TADF devices. A high EQE of 19.8% and lifetime exceeding that of the state-of-the-art green TADF emitter were demonstrated using one of the pyrimidine-5-carbonitrile derived emitters through the uniformly distributed electrostatic potential. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Related Products of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Related Products of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. These research results belong to Al-Rashood, Sara T.; Hamed, Ahmed R.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Al-Sanea, Mohammad M.; Eldehna, Wagdy M.. HPLC of Formula: 614-16-4 The article mentions the following:

In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic compounds Interestingly, no much attention has been paid to develop spirooxindole derivatives with dual antioxidant and anticancer activities. In this context, a series of spirooxindoles 6a-p was examined for their anticancer effect towards HepG2 hepatocellular carcinoma and PC-3 prostate cancer cell lines. Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells (IC50 = 6.9 and 11.8μM, resp.). Afterwards, spirooxindole 6a was assessed for its apoptosis induction potential in HepG2 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3,. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Novel phthalimide based analogues: Design, synthesis, biological evaluation, and molecular docking studies》 were Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; El-Naggar, Mohamed; Nossier, Eman S.; Amr, Abd El-Galil E.. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. SDS of cas: 614-16-4 The author mentioned the following in the article:

Pyrazolylphthalimide derivative I was synthesized and reacted with different reagents to afford the target imidazopyrazoles II, III, and IV, pyrazolopyrimidines V (R = NH2, R1 = CN, R2 = SMe; R = H, R1 = COPh, R2 = NH2; R = H, R1 = CN, R2 = NH2) and pyrazolotriazines VI (R3 = CN, R4 = NH2; R3 = CO2Et, R4 = Me) containing phthalimide moiety. The prepared compounds were established by different spectral data and elemental analyses. Addnl., all synthesized derivatives were screened for their antibacterial activity against four types of Gram + ve and Gram-ve strains, and for antifungal activity against two fungi micro-organisms by well diffusion method. Moreover, the antiproliferative activity was tested for all compounds against human liver (HepG-2) cell line in comparison with the reference vinblastine. Moreover, drug-likeness and toxicity risk parameters of the newly synthesized compounds were calculated using in-silico studies. The data from structure-activity relationship (SAR) anal. suggested that phthalimide derivative bearing 3-aminopyrazolone moiety, illustrated the best antimicrobial and antitumor activities and might be considered as a lead for further optimization. To investigate the mechanism of the antimicrobial and anticancer activities, enzymic assay and mol. docking studies were carried out on E. coli topoisomerase II DNA gyrase B and VEGFR-2 enzymes. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts