Category: 614-16-4

《Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes》 was published in RSC Advances in 2020. These research results belong to Jia, Qianfa; Lan, Yunfei; Ye, Xin; Lin, Yinhe; Ren, Qiao. Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The article mentions the following:

An efficient [4 + 2] benzannulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes was achieved under metal-free reaction conditions selectively delivering a wide range of polyfunctional benzenes in high yields resp. (up to 94% yield). In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jadhav, Chetan; Nipate, Amol; Chate, Asha; Gill, Charansingh published their research in ACS Omega in 2021. The article was titled 《Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids》.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The article contains the following contents:

An operationally simple, one-pot multicomponent reaction was developed for the assembly of pyrido[2,3-d]pyrimidine and pyrazolo[3,4-b]pyridine derivatives I [R1 = 4-ClC6H5, 2-OHC6H5, 4-BrC6H5; R2 = C6H5, 4-Cl-C6H5, etc], II [R1 = 4-ClC6H5, 4-MeC6H5 , 4-BrC6H5; R2 = C6H5, 4-ClC6H5; R3 = R4 = H, Me, etc], III [R1 = 4-ClC6H5, 4-MeC6H5; R2 = C6H5; R5 = NH2, etc] in excellent yields (92-94%) with high purity. The reactions were easy to perform simply by mixing of electron-rich amino heterocycles (including aminouracils and aminopyrazoles), aldehyde, and acyl acetonitrile in the presence of [Et3NH][HSO4] under solvent-free conditions. The remarkable feature of the present approach was that the ionic liquid possesses dual solvent-catalytic engineering capability. Results of this study revealed that 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60°C is the best reaction parameter for the construction of fused pyridine and pyrimidine derivatives I, II and III in excellent yields. The present methodol. showed good results under gram-scale conditions, thereby indicating its applicability in industrial as well as academic settings in the near future. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C9H7NOIn 2022 ,《Efficient synthesis of novel spiro[indoline-3,5′-pyrano-[2,3-d]pyrimidin]-2-one derivatives and antitumor activity evaluation》 was published in Heterocycles. The article was written by Li, Zhenhua; Huang, Guoqing; Rong, Dayou; Cao, Yingyan; Hu, Ronghui. The article contains the following contents:

An efficient method for synthesis of the spiro[indoline-3,5′-pyrano[2,3-d]pyrimidin]-2-one derivatives I [R1 = H, 7-Me, 5-Cl, etc.; R2 = H, Me; R3 = CN, C(O)Me, CO2Et; R4 = Me, Ph] from 2′-amino-2-oxospiro[indoline-3,4;-pyran]-3′-carbonitriles using bis(trichloromethyl) carbonate (BTC) and triphenylphosphine oxide (TPPO) was developed. A series of target compounds I with broad substrate scope were synthesized in moderate to good yields. Some of the compounds I were evaluated for antitumor activities against four cancer cell lines A549, HepG-2, MCF-7 and HeLa using 5-FU and cisplatin as reference and showed good antitumor activity when compared with the standard drugs. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Computed Properties of C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Computed Properties of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《A Complementary C-H Functionalization Mode of Benzoylacetonitriles: Computer-Augmented Study of a Regio- and Stereoselective Synthesis of Functionalized Benzofulvenes》 was published in Organic Letters in 2020. These research results belong to Song, Xia; Do Doan, Bao Nguyen; Zhang, Xinying; Lee, Richmond; Fan, Xuesen. Category: nitriles-buliding-blocks The article mentions the following:

A highly regio- and stereoselective synthesis of functionalized benzofulvenes via Rh(III)-catalyzed cascade reactions of benzoyl acetonitrile/methylsulfone/acetate with propargyl alcs. is presented herein. Mechanistic modeling performed with d. functional theory (DFT) calculations suggested that the hydroxyl group and CsOAc played important roles in mediating the 5-membered ring cyclization by forming a very thermodynamically stable Rh(III) intermediate. Another remarkable feature of this transformation is its excellent stereoselectivity in that only E-isomers are obtained. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C9H7NOIn 2020 ,《Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines》 appeared in Synthesis. The author of the article were Chikayuki, Yuya; Miyashige, Takakane; Yonekawa, Shiori; Kirita, Akiko; Matsuo, Natsuko; Teramoto, Hiroyoshi; Sasaki, Shigeru; Higashiyama, Kimio; Yamauchi, Takayasu. The article conveys some information:

A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N-propargyl enamines in solvent without additives. The total synthesis of onychine was achieved in 51% yield in only two steps by using this method. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,ChemistrySelect included an article by Chen, Jing; Ding, Yuxin; Gao, Yejun; Zhou, Dongheng; Hider, Robert; Ma, Yongmin Dr. Application of 614-16-4. The article was titled 《Selectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF》. The information in the text is summarized as follows:

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Electrochemical Synthesis of 1-Naphthols by Intermolecular Annulation of Alkynes with 1,3-Dicarbonyl Compounds》 was published in Organic Letters in 2020. These research results belong to He, Mu-Xue; Mo, Zu-Yu; Wang, Zi-Qiang; Cheng, Shi-Yan; Xie, Ren-Ren; Tang, Hai-Tao; Pan, Ying-Ming. SDS of cas: 614-16-4 The article mentions the following:

C-centered radical cyclization under electrochem. conditions is a feasible strategy for constructing cyclic structures. Reported herein is the electrochem. synthesis of highly functionalized 1-naphthols using alkynes and 1,3-dicarbonyl compounds by (4 + 2) annulation of C-centered radical. Electrolysis was conducted with Cp2Fe as redox catalyst, thereby eliminating the use of oxidants and transition-metal catalysts. The synthesized 1-naphthol compounds showed good antitumor activity in vitro, and further studies indicated that compound I induced tumor cell apoptosis. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Direct use of 1,3-dienes for the allylation of ketones via catalytic hydroindation》 was written by Suzuki, Itaru; Yagi, Kensuke; Miyamoto, Shinji; Shibata, Ikuya. Product Details of 614-16-4 And the article was included in RSC Advances in 2020. The article conveys some information:

In this study, in situ catalytically generated allylic indium from 1,3-dienes and InCl2H was developed for use in the allylation of ketones. This protocol resulted in the unprecedented establishment of a successive combining of quaternary C-C bonds, which could then be applied to many types of ketones. Other branched 1,3-dienes and vinyl cyclopropanes, could also be coupled with ketones to get homoallylic alcs. I [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = Me, Et, n-Pr, etc.] in a reaction where CuH would not be applicable. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Product Details of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Enamine Catalytic Annulation of Azonaphthalenes: An Access to Indole Derivatives》 were Zhao, Hanhui; Yuan, Huijun; Zhang, Yanru; Li, Rongshi; Li, Wenjun. And the article was published in Organic Letters in 2019. Electric Literature of C9H7NO The author mentioned the following in the article:

The secondary-amine mediated [3 + 2] annulation of azonaphthalenes with aldehydes and ketones is described for the first time, which provides an alternative protocol for the synthesis of indole derivatives It features a cheap and readily available catalyst, a broad scope of reactants, very mild reaction conditions, and high efficiency. Significantly different from the transition-metal-mediated processes, the enamine activation represents the first organic base-catalytic protocol for indole synthesis.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Electric Literature of C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Electric Literature of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Plakas, Konstantinos; Kalogirou, Andreas S.; Kourtellaris, Andreas; Koutentis, Panayiotis A. published an article in Molbank. The title of the article was 《Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride with 2-(Phenylsulfonyl)acetonitrile》.Recommanded Product: 614-16-4 The author mentioned the following in the article:

The reaction of 4,5-dichloro-1,2,3-dithiazolium chloride with nitriles (1 equiv) in the presence of pyridine (2 equiv) gave S-(3-chloro-5-cyanoisothiazol-4-yl)benzenesulfonothioate I in 19% and (Z)-2-(5H-1,2,3-dithiazol-5-ylidene)-2-acetonitriles II [R = CN, CO2Me, CO2Et, etc.] were reported. The compounds were fully characterized and the mechanistic rationale was proposed for the formation of the benzensulfonate. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Recommanded Product: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts