Category: 6136-93-2

Murakami, Teiichi; Otsuka, Masami; Kobayashi, Susumu; Ohno, Masaji published the artcile< Efficient synthesis of 3-formyl-1,2,4-triazole nucleoside using diethoxyacetonitrile as a synthon>, Safety of 2,2-Diethoxyacetonitrile, the main research area is triazolecarboxaldehyde; nucleoside triazolecarboxaldehyde; diethoxyacetonitrile synthon triazolecarboxaldehyde; cyclization diethoxyiminoethylhydrazinoribofuranose.

(EtO)2CHCN (I) was used as a synthon for the synthesis of 1,2,4-triazole-3-carboxaldehyde and nucleoside II. I was treated with MeOH in the presence of MeONa and the resultant (EtO)2CHC(:NH)OMe was treated with ribofuranose III (R = H) to give III [R = C(:NH)CH(OEt)2] (IV). IV was cyclized with HC(OEt)3 and the resultant nucleoside was deblocked to give II.

Heterocycles published new progress about Cyclization. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Safety of 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Patalag, Lukas J.; Jones, Peter G.; Werz, Daniel B. published the artcile< Aza-BOIMPYs: a tetrazole auxochrome for highly red-emissive dipyrromethene-based fluorophores>, Quality Control of 6136-93-2, the main research area is boron complex iminopyrrolide ligand fluorophore tetrazole auxochrome; BODIPY; BOIMPY; dyes; fluorophores; tetrazole.

A structural derivative of the recently designed BOIMPY motif is introduced; this derivative engages a meso tetrazole moiety and a dipyrromethene scaffold in a twofold BF2-coordination scheme. A one-pot synthesis allows the isolation of unusual dipyrro-perazafulvene precursors and subsequent access to nonfluorescent mono-BF2 and fluorescent bis-BF2 species. The novel fluorophore, denoted Aza-BOIMPY, is highly emissive (ΦF up to 0.82), structurally compact, and provides useful inherent polarity. Absorption and emission events focus at roughly 600 nm with exceptionally small Stokes shifts (209 cm-1) and high attenuation coefficients (up to 120 000 M-1 cm-1). X-ray crystallog. and computational investigations provide insights into geometrical and electronic properties of the novel dye type.

Chemistry – A European Journal published new progress about Chromophores, auxochromes. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Quality Control of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mai, Duy N.; Wolfe, John P. published the artcile< Asymmetric Palladium-Catalyzed Carboamination Reactions for the Synthesis of Enantiomerically Enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines>, Electric Literature of 6136-93-2, the main research area is pentenylamine asym carboamination bromide aryl alkenyl palladium catalyst; pyrrolidine arylmethyl asym preparation; alkenylmethyl pyrrolidine asym preparation; tylophorine asym preparation.

The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl)pyrrolidine derivatives, e.g., I, via Pd-catalyzed alkene carboamination reactions was described. These transformations generated enantiomerically enriched products with up to 94% ee from readily available alkenyl or aryl bromides and N-Boc-pent-4-enylamines. The application of this method to a concise asym. synthesis of (-)-tylophorine was also discussed.

Journal of the American Chemical Society published new progress about Amination catalysts (stereoselective, intramol., carbo-). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Glover, Christian; Merritt, Eleanor A.; Bagley, Mark C. published the artcile< Synthesis of saramycetic acid>, Electric Literature of 6136-93-2, the main research area is saramycetic acid preparation degradation product thiopeptide antibiotic cyclothiazomycin.

The first reported synthesis of saramycetic acid [2′-acetyl-[2,4′-bithiazole]-4-carboxylic acid], a degradation product of the complex thiopeptide antibiotic cyclothiazomycin, is achieved in nine steps and 11% overall yield from diethoxyacetonitrile by a strategy which incorporates two Hantzsch thiazole syntheses using thioamides prepared from the corresponding nitriles without the use of gaseous H2S. The synthetic material was transformed to Me saramycetate, which had spectroscopic properties in excellent agreement with the literature data.

Tetrahedron Letters published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tian, Shi-Kai; Hong, Ran; Deng, Li published the artcile< Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base>, SDS of cas: 6136-93-2, the main research area is ketone dialkoxy catalytic asym cyanosilylation chiral Lewis base; cyanohydrin silylated asym synthesis; cinchona alkaloid chiral catalyst enantioselective cyanosilylation dialkoxy ketone.

A highly enantioselective cyanosilylation of α,α-dialkoxy ketones R1COCH(OR2) (R1 = Me, Me2CH, n-Bu, Ph, 4-MeOC6H4, PhCH2, PhCH:CH, PhCC, etc.; R2 = Et, n-Pr) with trimethylsilyl cyanide catalyzed by modified cinchona alkaloids was developed. This reaction is the first highly enantioselective cyanosilylation of ketones catalyzed by an organic chiral Lewis base and, combined with the versatility of the acetal functionality, provides a broadly useful synthetic method for chiral building blocks bearing quaternary stereocenters. Acetal ketones, readily accessible but previously unexplored in asym. synthesis, demonstrate unusual reactivity and selectivity toward the nucleophilic cyanosilylation, thereby suggesting that they may be interesting substrates for other catalytic enantioselective reactions.

Journal of the American Chemical Society published new progress about Addition reaction, stereoselective (cyanosilylation). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ujjinamatada, Ravi K.; Agasimundin, Yankanagouda S.; Zhang, Peng; Hosmane, Ramachandra S.; Schuessler, Roman; Borowski, Peter; Kalicharran, Kishna; Fattom, Ali published the artcile< A Novel Imidazole Nucleoside Containing a Diamino-dihydro-S-triazine as a Substituent: Inhibitory Activity Against the West Nile Virus NTPase/Helicase>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is condensation ring enlargement guanosine imidazodiazepine guanidine deoxyerythropentofuranosyl ethoxycarbonylimidazolecarbaldehyde; helicase West Nile virus antiviral imidazole nucleoside aminodihydrotriazine synthesis; West Nile virus NTPase antiviral imidazole nucleoside aminodihydrotriazine synthesis.

The attempted synthesis of a ring-expanded guanosine containing the imidazo[4,5-e][1,3]diazepine ring system by condensation of 1-(2′-deoxy-β-D-erythropentofuranosyl)-4-ethoxycarbonylimidazole-5-carbaldehyde with guanidine resulted in the formation of an unexpected product, 1-(2′-deoxy-β-D-erythropentofuranosyl)-5-(2,4-diamino-3,6-dihydro-1,3,5-triazin-6-yl)imidazole-4-carboxamide (I). The structure as well as the pathway of formation of I was corroborated by isolation of the intermediate, followed by its conversion to the product. Nucleoside I showed promising in vitro anti-helicase activity against the West Nile virus NTPase/helicase with an IC50 of 3-10 μg/mL.

Nucleosides, Nucleotides & Nucleic Acids published new progress about Antiviral agents. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bagley, Mark C.; Chapaneri, Krishna; Glover, Christian; Merritt, Eleanor A. published the artcile< Simple microwave-assisted method for the synthesis of primary thioamides from nitriles>, Application of C6H11NO2, the main research area is nitrile reaction ammonium sulfide microwave irradiation; thioamide primary preparation.

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 °C or 130 °C in 15-30 min for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H2S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatog. purification

Synlett published new progress about Microwave irradiation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Si, Chong; Myers, Andrew G. published the artcile< A Versatile Synthesis of Substituted Isoquinolines>, SDS of cas: 6136-93-2, the main research area is isoquinoline preparation cyclization imine nitrile.

This communication present the direct assembly of substituted isoquinolines and biisoquinolines for use in versatile and unique methodologies for the construction of heterocyclic compounds

Angewandte Chemie, International Edition published new progress about Condensation reaction. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grimmett, M. R. published the artcile< Product class 3: imidazoles>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is review imidazole preparation cyclization aromatization ring transformation.

A review. Methods for preparing imidazoles are reviewed including cyclization, ring transformations, aromatization and modification of substituents on existing imidazoles.

Science of Synthesis published new progress about Aromatization. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kelly, T. Ross; Ohashi, Naohito; Armstrong-Chong, Rosemary J.; Bell, Stephen H. published the artcile< Synthesis of (±)-fredericamycin A>, Name: 2,2-Diethoxyacetonitrile, the main research area is fredericamycin A.

(±)-Fredericamycin A (I) was prepared via the regiospecific, Me3Si-directed coupling of indane II with anhydride III to give the coupling product IV. Formation of the spiro system is achieved by reduction of IV to a keto aldehyde which undergoes in situ cyclization to the spiro ketols.

Journal of the American Chemical Society published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Name: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts