Category: 613-46-7

Reference of 613-46-7, A common heterocyclic compound, 613-46-7, name is 2-Naphthonitrile, molecular formula is C11H7N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzonitrile 1a (1 mmol), Na2S*9H2O (1.2 mmol) and DMF (1 mL) were added into a 10 mL bottle. The reactor was placed in a heating magnetic stirrer at 130 C. After 2.5 h, by adding about 3 mL H2O after the reaction to disperse the solid product, the reaction mixture was extracted with EtOAc (3 x 3 mL), and the mixture was purified by column chromatography.

The synthetic route of 613-46-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Cao, Xian Ting; Yang, Huiyong; Zheng, Hui; Zhang, Pengfei; Heterocycles; vol. 96; 3; (2018); p. 509 – 517;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 613-46-7, name is 2-Naphthonitrile, A new synthetic method of this compound is introduced below., Safety of 2-Naphthonitrile

General procedure: Catalyst 1 (10 mol%) and HBpin (0.44 mmol) were added to aSchlenk flask inside the glove box, followed by the addition oforganic nitriles (0.2 mmol). The reaction mixture was heatedcontinuously at 65 C under neat condition or under toluene for astipulated time, as mentioned in Table 2. Toluene was then added,and the reaction mixture was filtered through a short plug of Celiteand evaporated under reduced pressure to obtain a solid residue.The diboryl amines are moisture- and air-sensitive, and henceexperimental procedures were conducted and NMR samples wereprepared inside the glove box. All products were characterizedusing multi-nuclear NMR spectroscopy, and details are given in thesupporting information.

The synthetic route of 613-46-7 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 613-46-7 as follows. category: nitriles-buliding-blocks

General procedure: A mixture of arylnitrile (2.0 mmol) and WR (1.07 g, 2.0 mmol) in 20 mL of dry toluene was refluxed for 8 h. Upon cooling to 90C 1.0 mL of water was added, the mixture was refluxed for another 1 h. After cooling to room temperature the reaction mixture was concentrated to ca. 5.0 mL and extracted with dichloromethane (20 mL x 3), the combined dichloromethane extracts were dried over MgSO4. The final residue was purified by silica gel chromatography (9 : 1 ethyl acetate /dichloromethane as eluent) to give the compounds 1a-1i.

According to the analysis of related databases, 613-46-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hua, Guoxiong; Du, Junyi; Slawin, Alexandra M. Z.; Woollins, J. Derek; Synlett; vol. 25; 15; (2014); p. 2189 – 2195;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts