Category: 612-24-8

Reference of 612-24-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 612-24-8 name is 2-Nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The mixture of nitroarene 2 (1.0 mmol), PhSTMS 1(1.2 mmol, 1.2 equiv.), and TBAF (1.2 mmol, 1.2 equiv.) in degassedacetonitrile (2 mL) was stirred at room temperature under N2 for2 h and the reaction was monitored by TLC. After completion of thereaction, the solvent was evaporated under reduced pressure andthe residue purified by flash column chromatography on silica gelto give 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Yu, Xiao-Chun; Li, Bo; Yu, Bao-Hua; Xu, Qing; Chinese Chemical Letters; vol. 24; 7; (2013); p. 605 – 608;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H4N2O2

General procedure: 2-Furonitrile 1m (186 mg, 2 mmol), NaN3 (260 mg, 4 mmol), BiCl3 (126 mg, 0.4 mmol), and 8 mL of a 3:1 isopropanol/water mixture were added to a 30-mL Pyrex microwave vessel, which was then capped. The microwave vessel was then placed in a Milestone Start Synth microwave reactor. The reaction was magnetically stirred and heated for 1 h at 150C. The reaction was monitored by thin-layer chromatography (TLC) using an ether/hexane mixture (typically 50/50) for development. The reaction mixture was then diluted with saturated aqueous sodium bicarbonate (20 mL) and was hed with ethyl acetate (2×15 mL). The aqueous sodium bicarbonate layer was cooled with ice and acidified to a pH of 2 or less with concentrated hydrochloric acid, which was added dropwise. The precipitate formed was extracted with ethyl acetate (3×15 mL). The combined organic layers were dried with anhydrous sodium sulfate and decanted into a tared round-bottom flask. The organic layer was concentrated under reduced pressure by rotary evaporation at 40C and then under high vacuum. The tetrazole product was recrystallized from ethyl acetate and hexane.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 612-24-8, its application will become more common.

Reference:
Article; Coca, Adiel; Feinn, Liana; Dudley, Joshua; Synthetic Communications; vol. 45; 8; (2015); p. 1023 – 1030;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 612-24-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 612-24-8, name is 2-Nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Nitro aromatic (1.0 mmol), B2(OH)4 (5.0 equiv, 5.0 mmol), and H2O (3.0 mL) were added in a10 mL tube. The reaction mixture was stirred at 80 C for 8 h. When the reaction was completemonitored by TLC, the mixture was cooled to room temperature, extracted with ethyl acetate (3 ×20 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gel columnchromatography.

The synthetic route of 2-Nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Danyi; Zhou, Yanmei; Zhou, Haifeng; Liu, Sensheng; Liu, Qixing; Zhang, Kaili; Uozumi, Yasuhiro; Synlett; vol. 29; 13; (2018); p. 1765 – 1768;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 612-24-8, name is 2-Nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 612-24-8, COA of Formula: C7H4N2O2

General procedure: TAPEHA-Pd (0.015 g) was added to a solution of nitroarenes (1.0 mmol) in EtOH (20 mL). After N2H4 .H2O(4.0 mmol) was added the color of the catalyst was turned to black rapidly in the same way as reducing with NaBH4 . This color change means formation of palladium nanoparticles43 TAPEHA-PdNPs as mentioned above. After being stirred for 20 min at room temperature and atmospheric pressure, the catalyst was removedby ltering and EtOH was removed under a vacuum.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Nitrobenzonitrile, and friends who are interested can also refer to it.

Electric Literature of 612-24-8,Some common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a suspension of a respective 2-nitro-benzonitrile 3a,b or 7a,b (15 mmol) in water (10 mL) was added sodium dithionite (60 mmol), and the reaction mixture was heated to 50C and stirred at this temperature for 3-4 h. Then, the temperature was raised to 65C and concentrated HCl (5 mL) was added dropwise in 30 min. The resulting mixture was cooled to 20C, and the pH was adjusted to ~10 using 50% aqueous sodium hydroxide solution. The formed precipitate was filtered, washed with cold water, n-hexane, and dried at 40oC to afford 2-nitro-benzonitriles 8a-d, respectively.

The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Le-Nhat-Thuy, Giang; Dinh, Thuy Van; Pham-The, Hai; Nguyen Quang, Hung; Nguyen Thi, Nga; Dang Thi, Tuyet Anh; Hoang Thi, Phuong; Le Thi, Tu Anh; Nguyen, Ha Thanh; Nguyen Thanh, Phuong; Le Duc, Trung; Nguyen, Tuyen Van; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3741 – 3747;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 612-24-8, The chemical industry reduces the impact on the environment during synthesis 612-24-8, name is 2-Nitrobenzonitrile, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of benzonitriles (2a-p) (0.009 mol), sodium azide (0.009 mol) was dissolved in DIPEAc (5 ml) and allowed to stirr for 30 min at 80 FontWeight=”Bold” FontSize=”10″ C. After completion of the reaction (monitored by thin-layer chromatography, TLC), the reaction mixture was cooled to room temperature and poured on crushed ice. To it 5N HCl (10 mL) was added and stirred vigorously. Otained solid products was filtered and crystallized from ethanol. The synthesized compounds were confirmed by Melting points, IR, 1H and 13C NMR which were in good agreement with those reported in the literature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bhosle, Manisha R.; Shaikh, Dastgir S.; Khillare, Lalit D.; Deshmukh, Amarsinh R.; Mane, Ramrao A.; Synthetic Communications; vol. 47; 7; (2017); p. 695 – 703;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 612-24-8, A common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Nitrobenzene (0.6mmol), 5wt% Pd/C (0.5mmol %, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3¡Á5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99%).

The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Yanmei; Zhou, Haifeng; Liu, Sensheng; Pi, Danwei; Shen, Guanshuo; Tetrahedron; vol. 73; 27-28; (2017); p. 3898 – 3904;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 612-24-8, name is 2-Nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4N2O2

General procedure: SAC (300mg) and NaBH4 (4.0mmol) were added to a solution of nitroarenes (1.0mmol) in EtOH/water (1/1) (20ml). The reaction mixture was stirred for 4h at the temperature indicated in Table3. At the end of the reaction, the catalyst was removed by filtering and the filtrate was extracted with 3¡Á70ml EtOAc. The combined organic layers were dried over MgSO4 and concentrated in a vacuum.

According to the analysis of related databases, 612-24-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Genc, Hayriye; Catalysis Communications; vol. 67; (2015); p. 64 – 67;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 612-24-8

General procedure: A round bottom flask equipped with a magnetic stirrer bar was charged with the 2-nitroacylbenzene (1.00 mmol) in EtOAc-MeOH (1:1; 5 mL). SnCl2.H2O (3.00 mmol) was added and the reaction stirred at room temperature overnight. The reaction was partitioned between DCM (30 mL) and NaHCO3 (20 mL). The aqueous phase was extracted with DCM (3 ¡Á 10 mL) and the organic portions combined, washed with H2O (10 mL), saturated aqueous NaCl (10 mL), dried over MgSO4, filtered and reduced in vacuo. The residue was purified by column chromatography (SiO2, hexane/EtOAc) to provide the title compound. General procedure gave the title compound as an orange solid (116 mg, 87 %).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 612-24-8.

Reference:
Article; Chauhan, Jay; Fletcher, Steven; Tetrahedron Letters; vol. 53; 37; (2012); p. 4951 – 4954;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts