Category: 612-13-5

Ragulin, V. V. published the artcileDouble Arbuzov Reaction. Synthesis of Bis(ω-cyanoalkyl)phosphinic Acids, Synthetic Route of 612-13-5, the publication is Russian Journal of General Chemistry (2019), 89(8), 1728-1730, database is CAplus.

A general method for the synthesis of sym. bis(ω-cyanoalkyl)phosphinic acids from ammonium hypophosphite is proposed. The reaction of bis(trimethylsilyl)hypophosphite generated in situ with the ω-bromoalkylnitrile mol. according to the Arbuzov reaction and the subsequent silylation of the hydrophosphoryl intermediate gives bis(trimethylsilyl)phosphonite. The latter reacts with the 2nd ω-haloalkylnitrile mol. by the Arbuzov reaction with the formation of the 2nd P-C bond.

Russian Journal of General Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ni, Jie published the artcileFluorescent brightening agent S-ER, Name: 2-(Chloromethyl)benzonitrile, the publication is Yinran (2014), 40(11), 35-37, database is CAplus.

1,4-Bis (2-cyano-styryl) benzene, a fluorescent whitening agent S-ER is prepared with o-toluene cyanide, tri-Et phosphite and terephthaldehyde as raw materials, and then is applied to polyester fiber dyeing. The whitening agent S-ER has better whitening effect than the conventional whitening agent DT with the amount only 1/10-1/12 of DT.

Yinran published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xu, Lu-Feng published the artcileSynthesis of 2-aryloxymethylbenzonitriles from 2-cyanobenzyl chloride, SDS of cas: 612-13-5, the publication is Asian Journal of Chemistry (2012), 24(11), 5329-5331, database is CAplus.

2-[(Aryloxy)methyl]benzonitriles were synthesized from 2-cyanobenzyl chloride and phenols with K₂CO₃ as a base in DMF at 80-110° in good to excellent yields. 2-Cyanobenzyl chloride is a better alternative to the more costly and less atom economical bromo analog or chloro- or bromobenzoate.

Asian Journal of Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H5N3S, SDS of cas: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhou, Wenjun published the artcileSynthesis and characterization of o-cyanostilbenes, Application In Synthesis of 612-13-5, the publication is Huagong Shengchan Yu Jishu (2011), 18(3), 28-31, database is CAplus.

The preparation and characterization of five o-cyanostilbenes from o-cyanobenzyl chloride, tri-Et phosphate, aromatic aldehydes in N,N-DMF via Wittig-Horner reaction with yields ranged from 83.8% to 93.1% were reported. The reported method had the advantages of reliable and high yields, simple operations, cheap and readily available raw materials.

Huagong Shengchan Yu Jishu published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C15H24O2, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xie, Yan published the artcileSynthesis of 2-(2-Aryl)ethylbenzoic acid, Computed Properties of 612-13-5, the publication is Zhongguo Yiyao Gongye Zazhi (2012), 43(2), 87-89, database is CAplus.

2-(2-Phenylethyl)benzoic acid or 2-(thiophene-2-ylethyl)benzoic acid was synthesized from o-cyanobenzyl chloride via Wittig-Horner reaction with benzaldehyde or 2-thiopene carboxaldehyde, hydrolysis and then hydrogenation, with the overall yield of about 64% or 60%.

Zhongguo Yiyao Gongye Zazhi published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C3H7NO2, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Yicun published the artcileDesign, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity, Quality Control of 612-13-5, the publication is PLoS One (2011), 6(11), e27673, database is CAplus and MEDLINE.

Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator activity. Compounds were screened for vasodilatory activity on isolated thoracic aorta rings from rats, and their quant. structure-activity relationships (QSAR) were examined Based on the result of QSAR, N-4-tert-Bu benzyl haloperidol chloride (16c) was synthesized and showed the most potent vasodilatory activity of all designed compounds 16C dose-dependently inhibited the contraction caused by the influx of extracellular Ca²⁺ in isolated thoracic aorta rings from rats. It concentration-dependently attenuated the calcium channel current and extracellular Ca²⁺ influx, without affecting the intracellular Ca²⁺ mobilization, in vascular smooth muscle cells from rats. 16C, possessing the N-4-tert-Bu benzyl piperidine structure, as a novel calcium antagonist, may be effective as a calcium channel blocker in cardiovascular disease.

PLoS One published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Liu, Dengyue published the artcileFirst Discovery of Novel Pyrido[1,2-a]pyrimidinone Mesoionic Compounds as Antibacterial Agents, Category: nitriles-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2019), 67(43), 11860-11866, database is CAplus and MEDLINE.

Plant bacterial diseases cause tremendous decreases in crop yield and quality, and there is a lack of highly effective and low-risk antibacterial agents. A series of novel pyrido[1,2-a]pyrimidinone mesoionic compounds containing vanillin moieties were synthesized, and the application of these mesoionic compounds as plant antibacterial agents was reported here for the first time. The bioassay results revealed that the mesoionic compounds had good antibacterial activity. Of these compounds, compound (I) showed excellent in vitro activity against Xanthomonas oryzae pv. oryzae, with an EC₅₀ value of 1.1μg/mL, which was substantially better than that of bismerthiazol (92.7μg/mL) and thiodiazole copper (105.4μg/mL). Moreover, greenhouse condition trials indicated that the protective and curative activities of compound I against rice bacterial leaf blight were 75.12% and 72.04%, resp., which were better than those of bismerthiazol (62.24% and 50.83%, resp.) and thiodiazole copper (53.35% and 65.04%, resp.). These results provide a basis for the application of mesoionic vanillin moieties as new antibacterial agents.

Journal of Agricultural and Food Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Wen-Xin published the artcileHighly efficient amination in neat water of benzyl chlorides with dialkylformamides catalyzed by N-heterocyclic carbene-palladium(II)-1-methylimidazole complex, Computed Properties of 612-13-5, the publication is Journal of Chemical Research (2013), 37(10), 611-614, database is CAplus.

N,N-dialkylbenzylamines were synthesized from substituted benzyl chlorides and dialkylformamides in good to almost quant. yields in a eco-friendly solvent, water, in the presence of NHC-Pd(II)-Im complex.

Journal of Chemical Research published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Fu, Dan published the artcileCopper-mediated trifluoromethylation of 5-iodotriazole with (trifluoromethyl)trimethylsilane promoted by silver carbonate, Quality Control of 612-13-5, the publication is Journal of Fluorine Chemistry (2013), 170-176, database is CAplus.

A novel and mild method for copper-mediated trifluoromethylation of 5-iodotriazole using (trifluoromethyl)trimethylsilane (Me₃SiCF₃) as trifluoromethylating reagent with the assistance of Ag₂CO₃ was developed.

Journal of Fluorine Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhao, Guangkuan published the artcileEfficient synthesis of diarylmethane derivatives by PdCl₂ catalyzed cross-coupling reactions of benzyl chlorides with aryl boronic acids in aqueous medium, Related Products of nitriles-buliding-blocks, the publication is Tetrahedron Letters (2015), 56(48), 6700-6703, database is CAplus.

The research provides a simple and efficient method for preparing diarylmethane derivatives using the cross-coupling reaction of benzyl chlorides and aryl boronic acids catalyzed by palladium chloride in DMF aqueous solution without addnl. ligand.

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C24H26ClNO4, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts