Category: 610-66-2

610-66-2, A common heterocyclic compound, 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Absolute ethanol (2,250 ml) and 1,500 g (9.25 moles) of o-nitrophenylacetonitrile are charged into a 22 liter flask. The suspension is cooled to 5-10 and hydrogen chloride is bubbled into the mixture for 2.5 hours. The reaction mixture is stirred at 10 under nitrogen atmosphere overnight. It was then diluted with 16,000 ml of ether and stirred for 1 hour; the solid is collected by filtration, washed with 4*1,000 ml of ether and dried (5 mm Hg/40) to give ethyl 2-(2-nitrophenyl)acetimidate hydrochloride, m.p. 122-123 (dec).

The synthetic route of 610-66-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ciba-Geigy Corporation; US4460587; (1984); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

610-66-2, Adding a certain compound to certain chemical reactions, such as: 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 610-66-2.

To a solution of 2- nitrophenylacetonitrile (162 mg, 1 mmol) in anhydrous DMSO (5 mL) was added K2C03 (152 mg, 1.1 mmol) and the reaction mixture was stirred for 10 min under nitrogen atmosphere. Butyl iodide (125 //L, 1.1 mmol) was added to the reaction mixture and the stirring was continued for 3 h. Water was added to the reaction mixture and it was extracted with EtOAc (3 x 20 mL). The combined organic layer was dried over Na2S04, concentrated under reduced pressure, and the crude material was purified by silica gel column chromatography (10%> EtOAc/hexanes) to afford compound A2 as a pale yellow oil (174 mg, 80%>). Rf = 0.50 (10%> EtOAc/hexanes).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Nitrophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF KANSAS; DAVID, Sunil, Abraham; YOO, Euna; SHUKLA, Nikunj; SALYER, Alex, Christopher; BEESU, Mallesh; MALLADI, Subbalakshmi, S.; JONES, Cassandra; WO2015/23958; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts