Category: 610-66-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-(2-Nitrophenyl)acetonitrile

Absolute ethanol (2,250 ml) and 1,500 g (9.25 moles) of o-nitrophenylacetonitrile is charged into a 22 liter flask. The suspension is cooled to 5-10 and hydrogen chloride is bubbled into the mixture for 2.5 hours. The reaction mixture is stirred at 10 under nitrogen atmosphere overnight. It is then diluted with 16,000 ml of ether and stirred for 1 hour; the solid is collected by filtration, washed with 4*1,000 ml of ether and dried (5 mm Hg/40) to give ethyl 2-(o-nitrophenyl)-acetimidate hydrochloride, m.p. 122-123 (dec).

The synthetic route of 610-66-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ciba-Geigy Corporation; US4595535; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(2-Nitrophenyl)acetonitrile

In a 1000ml three-necked round bottom flask equipped with a mechanical stirrer, thermometer and condenser, add 2-nitrophenylacetonitrile (32g, 0.2mol), 2-chloro-4,6-dimethoxy-1,3 5-Triazine (53 g, 0.3 mol), N, N-dimethylformamide (400 mL), stirred for 10 minutes, after the reaction material is dissolved, potassium carbonate (41 g, 0.3 mol) is added, and then the temperature is raised to 90 degrees to react 24 hours.After monitoring the reaction, the system was naturally cooled to room temperature, and the next oxidation operation was directly performed. Under mechanical agitation, 30% hydrogen peroxide (91 g, 0.8 mol) was slowly added dropwise to the system cooled down to room temperature to control the system temperature not to exceed 70 degrees.After the dropwise addition, the mixture was stirred at room temperature for 10 hours. Pour into 500mL of water and stir, the solid is precipitated and filtered directly,Wash the filter cake with a small amount of water to obtain 40 g of solid product (4,6-dimethoxy-1,3,5-triazin-2-yl) (2-nitrophenyl) methanoneThe yield is 70%.

The synthetic route of 610-66-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Chemical Institute; Luo Hongwen; Zhang Jiaxing; Xu Shouming; Mei Liyun; Fan Zhen; (11 pag.)CN110981825; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 610-66-2,Some common heterocyclic compound, 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of the correspongding catalyst 4k (5 mol%), K2CO3 (2 equiv) and 2-(2-nitrophenyl)acetonitrile (0.10 mmol) in CH2Cl2 (1.0 mL), and then was cooled to -20 C before the imines (0.12 mmol) was introduced. When the reaction was finished (determined by TLC analysis), the crude mixture was warmed to room temperature and purified by flash column chromatography (silica gel: petroleum ether/AcOEt = 5:1) to afford the products

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Nitrophenyl)acetonitrile, its application will become more common.

Reference:
Article; Pan, Renming; Zhang, Jiaxing; Zheng, Changwu; Wang, Hongyu; Cao, Dongdong; Cao, Weiguo; Zhao, Gang; Tetrahedron; vol. 73; 17; (2017); p. 2349 – 2358;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 610-66-2 as follows. Product Details of 610-66-2

2-Nitrobenzyl cyanide (1 g, 6.2 mmol) was dissolved in 4N hydrochloric acid dioxane solution (10 ml) and ethanol (2 ml) and the mixture was stirred at room temperature for 2 days. The solvent was evaporated and the obtained crude product was dissolved in ethanol (10 ml). Ammonium carbonate (1.0 g) was added, and the mixture was stirred overnight. After filtration of ammonium carbonate, the solvent was evaporated. Toluene (10 ml), diisopropylethylamine (1.2 ml, 7.3 mmol) and 2-amino-1,1,3-tricyano-1-propene (510 mg, 4.2 mmol) were added to the obtained crude product and the mixture was stirred at 110 C. for 2 hr. A treatment according to a conventional method using ethyl acetate as an extraction solvent gave a crude product, which was successively purified by silica gel column chromatography to give a nitrile intermediate (70 mg)

According to the analysis of related databases, 610-66-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yamada, Tatsuhiro; Nakagawa, Tadakiyo; Tanaka, Yasuhiro; Fujita, Kohichi; Tagami, Tomoyuki; Ikenoue, Yuka; Fukuda, Shunsuke; Chujo, Yoshitomo; Suzuki, Manabu; Murata, Masahiro; US2005/250796; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 610-66-2, Recommanded Product: 610-66-2

(1) According to a literature (Grob, C.A.; Helv Chim Acta 1961, 44, 1748.), (2-nitrophenyl)acetonitrile was synthesized from 1-chloro-2-nitrobenzene via (+/-)-ethyl cyano(2-nitrophenyl)acetate. Then, (2-nitrophenyl)acetonitrile (3.37 g) was subjected to catalytic hydrogenation in methanol (17 mL) under a normal pressure using 0.15 g of 10% Pd-C (54% wet). The catalyst was removed by filtration and the solvent was evaporated. Diisopropyl ether (20 mL) was added to the resulting concentrated residue and crystals were recovered by filtration to obtain (2-aminophenyl)acetonitrile (2.05 g). FAB (pos.): m/z 133

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Nitrophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1367058; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(2-Nitrophenyl)acetonitrile

Absolute ethanol (2,250 ml) and 1,500 g (9.25 moles) of o-nitrophenylacetonitrile is charged into a 22 liter flask. The suspension is cooled to 5-10 and hydrogen chloride is bubbled into the mixture for 2.5 hours. The reaction mixture is stirred at 10 under nitrogen atmosphere overnight. It is then diluted with 16,000 ml of ether and stirred for 1 hour; the solid is collected by filtration, washed with 4*1,000 ml of ether and dried (5 mm Hg/40) to give ethyl 2-(o-nitrophenyl)-acetimidate hydrochloride, m.p. 122-123 (dec).

The synthetic route of 610-66-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ciba-Geigy Corporation; US4595535; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 610-66-2 as follows. name: 2-(2-Nitrophenyl)acetonitrile

A suspension of (2-nitrophenyl)-acetonitrile (30 g, 185 mmol) and 10% palladium on carbon (2 g) in acetic acid (450 mL) was hydrogenated in a Parr apparatus under 30 psi pressure at ambient temperature for 2 hours. The mixture was filtered through a Celite pad and the filtrate was concentrated in vacuo. The obtained residue was dissolved in ethyl acetate (250 mL). The resulting solution was washed with water (2*100 mL) and saturated sodium chloride (50 mL), and then dried over anhydrous sodium sulfate and concentrated in vacuo to yield product. The crude material was purified by column chromatography (100-200 mesh silica gel) using 8% ethyl acetate in petroleum ether as eluent to afford (2-aminophenyl)acetonitrile (13.5 g, 55%) as a solid. 1HNMR (CDCl3) delta ppm 7.3-7.1 (m, 2H), 6.9-6.7 (m, 2H), 3.7 (br, 2H), 3.5 (s, 2H).

According to the analysis of related databases, 610-66-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-(2-Nitrophenyl)acetonitrile

General procedure: To a solution of the correspongding catalyst 4k (5 mol%), K2CO3 (2 equiv) and 2-(2-nitrophenyl)acetonitrile (0.10 mmol) in CH2Cl2 (1.0 mL), and then was cooled to -20 C before the imines (0.12 mmol) was introduced. When the reaction was finished (determined by TLC analysis), the crude mixture was warmed to room temperature and purified by flash column chromatography (silica gel: petroleum ether/AcOEt = 5:1) to afford the products

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 610-66-2.

Reference:
Article; Pan, Renming; Zhang, Jiaxing; Zheng, Changwu; Wang, Hongyu; Cao, Dongdong; Cao, Weiguo; Zhao, Gang; Tetrahedron; vol. 73; 17; (2017); p. 2349 – 2358;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

General procedure: To a solution of the correspongding catalyst 4k (5 mol%), K2CO3 (2 equiv) and 2-(2-nitrophenyl)acetonitrile (0.10 mmol) in CH2Cl2 (1.0 mL), and then was cooled to -20 C before the imines (0.12 mmol) was introduced. When the reaction was finished (determined by TLC analysis), the crude mixture was warmed to room temperature and purified by flash column chromatography (silica gel: petroleum ether/AcOEt = 5:1) to afford the products

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Pan, Renming; Zhang, Jiaxing; Zheng, Changwu; Wang, Hongyu; Cao, Dongdong; Cao, Weiguo; Zhao, Gang; Tetrahedron; vol. 73; 17; (2017); p. 2349 – 2358;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 610-66-2

General procedure: A mixture of aromaticaldehyde 1 (10 mmol), active methylene compound2 (10 mmol), and nano-ZnO catalyst (5 mol %) inaqueous ethanol (10 mL) was stirred under refl ux. Theformation of the products was monitored by TLC. Aftercompletion of the reaction (by TLC), the mixture wascooled to room temperature and fi ltered. The fi ltratewas concentrated to obtain a crude product, which waspurifi ed by recrystallization from aqueous ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 610-66-2, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Alam, M. M.; Asiri, Ya. I.; Sulthana, S. Sh.; Tasqeeruddin, S.; Russian Journal of Organic Chemistry; vol. 56; 2; (2020); p. 315 – 321;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts