Category: 60979-25-1

Legnani, Luca et al. published their research in ACS Catalysis in 2016 | CAS: 60979-25-1

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Electric Literature of C8H8N2O

Direct and Practical Synthesis of Primary Anilines through Iron-Catalyzed C-H Bond Amination was written by Legnani, Luca;Prina Cerai, Gabriele;Morandi, Bill. And the article was included in ACS Catalysis in 2016.Electric Literature of C8H8N2O This article mentions the following:

The direct C-H amination of arenes is an important strategy to streamline the discovery and preparation of functional mols. Herein, we report an operationally simple arene C-H amination reaction that, in contrast to most literature precedence, affords directly the synthetically versatile primary aniline products without relying on protecting group manipulations. Inexpensive Fe(II) sulfate serves as a convenient catalyst for the transformation. The reaction tolerates a wide scope of arenes, including structurally complex drugs. Importantly, the arene substrates are used as limiting reagents in the transformation. This operationally simple transformation should considerably accelerate the discovery of medicines and functional mols. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1Electric Literature of C8H8N2O).

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Electric Literature of C8H8N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Legnani, Luca et al. published their research in ACS Catalysis in 2016 | CAS: 60979-25-1

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Electric Literature of C8H8N2O

Direct and Practical Synthesis of Primary Anilines through Iron-Catalyzed C-H Bond Amination was written by Legnani, Luca;Prina Cerai, Gabriele;Morandi, Bill. And the article was included in ACS Catalysis in 2016.Electric Literature of C8H8N2O This article mentions the following:

The direct C-H amination of arenes is an important strategy to streamline the discovery and preparation of functional mols. Herein, we report an operationally simple arene C-H amination reaction that, in contrast to most literature precedence, affords directly the synthetically versatile primary aniline products without relying on protecting group manipulations. Inexpensive Fe(II) sulfate serves as a convenient catalyst for the transformation. The reaction tolerates a wide scope of arenes, including structurally complex drugs. Importantly, the arene substrates are used as limiting reagents in the transformation. This operationally simple transformation should considerably accelerate the discovery of medicines and functional mols. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1Electric Literature of C8H8N2O).

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Electric Literature of C8H8N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Iwamura, Hajime et al. published their research in Journal of Medicinal Chemistry in 1980 | CAS: 60979-25-1

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.SDS of cas: 60979-25-1

Structure-taste relationship of perillartine and nitro- and cyanoaniline derivatives was written by Iwamura, Hajime. And the article was included in Journal of Medicinal Chemistry in 1980.SDS of cas: 60979-25-1 This article mentions the following:

The relation between structure and taste potency of perillartine (I) and its analogs was investigated quant. by physicochem. parameters and regression anal. The results indicated that the hydrophobicity estimated from the octanol/water partition coefficient and the mol. widths from the bond axis connecting the oxime C atom and alicyclic ring are important, regardless of whether the taste is sweet or bitter, so far as taste potency is concerned. The structure-activity relation for the sweet/bitter ratio was not established quant., but the mol. width and thickness and the position-specific electronic effect appeared to delineate the ratio qual.; i.e., in principle, the wider and(or) the thicker the mol., the more bitter the taste. The quant. structure-activity relation of 5-nitro- and 5-cyanoaniline sweetener was formulated to show the nonsignificance of hydrophobicity within the compounds investigated but the importance of steric dimensions in determining the activity. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1SDS of cas: 60979-25-1).

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.SDS of cas: 60979-25-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Morofuji, Tatsuya et al. published their research in Organic Letters in 2020 | CAS: 60979-25-1

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Computed Properties of C8H8N2O

Photocatalytic C-H Amination of Aromatics Overcoming Redox Potential Limitations was written by Morofuji, Tatsuya;Ikarashi, Gun;Kano, Naokazu. And the article was included in Organic Letters in 2020.Computed Properties of C8H8N2O This article mentions the following:

The photocatalytic C-H amination of aromatics overcoming redox potential limitations was reported. Radical cations of aromatic compounds were generated photocatalytically using Ru(phen)3(PF6)2, which had a reduction potential at a high oxidation state (Ered(RuIII/RuII) = +1.37 V vs SCE) lower than the oxidation potentials of aromatic substrates (Eox = +1.65 to +2.27 V vs SCE). The radical cations were trapped with pyridine to give N-arylpyridinium ions, which were converted to aromatic amines. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1Computed Properties of C8H8N2O).

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Computed Properties of C8H8N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts