In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60899-34-5, name is 1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 60899-34-5
PREPARATION 10 1-hydroxy-4-indanecarbonitrile (racemic) 1.46 g of 4-cyano-1-indanone in 131 ml of tetrahydrofuran is cooled to +5 C., 1 g of potassium borohydride is added in small fractions, with agitation for one hour 15 minutes, followed by pouring over 200 ml of water containing sodium chloride, and extraction with isopropyl ether. The organic phase is dried, brought to dryness under reduced pressure and the residue is chromatographed on silica in a hexane-ethyl acetate mixture (6-4). 1.40 g of expected product is obtained, M.p.=98 C.
The synthetic route of 60899-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Roussel Uclaf; US5180741; (1993); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts