Category: 606080-43-7

Related Products of 606080-43-7, The chemical industry reduces the impact on the environment during synthesis 606080-43-7, name is Methyl 2-cyano-5-fluorobenzoate, I believe this compound will play a more active role in future production and life.

[0150] Step b: To a stirred solution of methyl 2-cyano-5-fluorobenzoate (3.85 g, 21.5 mmol) in tetrahydrofuran (30 mL) and water (3 mL) at 0 C was added lithium hydroxide monohydrate (1.11 g, 26.5 mmol). The reaction was warmed up to rt and stirred for 1 h. Then the solvent was evaporated and the residue was diluted with water (100 mL) and 2 M HCI (20 mL). The solid was collected by filtration and dried under vacuum to give the desired product. MS: (ES) m/z calculated for C8H4FN02[M+H]+166.0, found 166.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyano-5-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHEMOCENTRYX, INC.; CHEN, Xi; DRAGOLI, Dean, R.; FAN, Junfa; KALISIAK, Jaroslaw; LELETI, Manmohan, Reddy; MALATHONG, Viengkham; MCMAHON, Jeffrey; TANKAKA, Hiroko; YANG, Ju; YU, Chao; ZHANG, Penglie; MALI, Venkat; (104 pag.)WO2017/87610; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

606080-43-7, name is Methyl 2-cyano-5-fluorobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

b) Synthesis of 2-Cyano-5-dimethylamino-benzoic acid methyl ester (21b). To a stirred solution of 4.03 g (22,5 mmol) 21a and 60.0 ml dimethylsulphoxid are added 2.23 g (27.0 mmol) dimethylamine hydrochloride and 6.54 g (47.3 mmol) potassium carbonate. The reaction mixture is stirred for 15h at 65C in an autoclave and is reduced with high vacuum rotation evaporator at 65C. The residue is diluted with dichloromethane, washed twice with water. The combined water phases are extracted with dichloromethane. The combined dichloromethane phases are washed with diluted sodium hydrogen carbonate solution, dried with sodium sulphate and concentrated. The oily crude is purified by column chromatography and the desired product 21b is obtained in 89.0 % yield (4.09 g, 20.0 mmol). MS-ESI: 205 (M+ +1, 100),

The synthetic route of 606080-43-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1897885; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 606080-43-7,Some common heterocyclic compound, 606080-43-7, name is Methyl 2-cyano-5-fluorobenzoate, molecular formula is C9H6FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl 2-cyano-5-fluorobenzoate (11.2 g, 62.5 mmol), tert-butyl piperazine-1-carboxylate (15.1 g, 81.3 mmol) and potassium carbonate (9.50 g, 68.8 mmol) in DMSO (130 mL) was stirred at room temperature for 1 day. The mixture was diluted with water and precipitates formed were collected by filtration, washed with water and was dissolved in a mixture of ethyl acetate and methanol. The solution was washed with water and concentrated in vacuo. The residue was crystallized from ethyl acetate-hexane to give 13 (9.89 g, 46%). 1H NMR (CDCl3) delta 1.49 (s, 9H), 3.363.39 (m, 4H), 3.593.61 (m, 4H), 3.99 (s, 3H), 6.99 (dd, J = 2.7 Hz, 8.8 Hz, 1H), 7.54 (d, J = 2.7 Hz, 1H), 7.63 (d, J = 8.8 Hz, 1H). Anal. Calcd for C18H23N3O4: C, 62.59; H, 6.71; N, 12.17. Found: C, 62.52; H, 6.57; N, 12.11.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-cyano-5-fluorobenzoate, its application will become more common.

Reference:
Article; Yamashita, Tohru; Kamata, Makoto; Endo, Satoshi; Yamamoto, Mitsuo; Kakegawa, Keiko; Watanabe, Hiroyuki; Miwa, Katsuhiko; Yamano, Toru; Funata, Masaaki; Sakamoto, Jyun-Ichi; Tani, Akiyoshi; Mol, Clifford D.; Zou, Hua; Dougan, Douglas R.; Sang, BiChing; Snell, Gyorgy; Fukatsu, Kohji; Bioorganic and Medicinal Chemistry Letters; vol. 21; 21; (2011); p. 6314 – 6318;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts