Category: 59997-51-2

Related Products of 59997-51-2,Some common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At room temperature 4,4-dimethyl-3-oxopentanenitrile (J-Il) (1 eq., 5 g) was taken up in EtOH (100 ml), mixed with hydrazine hydrate (2 eq., 4.42 g) and refluxed for 3 h. The residue obtained after removal of the EtOH by distillation was taken up in water (100 ml) and extracted with EE (300 ml). The combined organic phases were dried over sodium sulphate, the solvent was removed under vacuum and the product (J-III) (5 g, 89 % yield) was obtained as a light red solid after recrystallisation from hexane (200 ml).

The synthetic route of 59997-51-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeon-Seop; WO2010/127856; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4,4-Dimethyl-3-oxopentanenitrile

(4) Synthesis of Intermediate (d)Water (128 mL) was added to 50 g (357 mmol) of Intermediate (c), and the mixture was stirred at room temperature. To this suspension, 98.2 g (785 mmol) of pivaloylacetonitrile was added, and aqueous 12 M hydrochloric acid was added dropwise at the same temperature to adjust the pH to 3. Thereafter, the resulting mixture was heated until the interior temperature became 50 C., and stirred at the same temperature for 6 hours. After the completion of reaction, the reaction solution was neutralized by adding an aqueous 8N potassium hydroxide solution to a pH of 6.4 and then cooled by ice cooling until the internal temperature became 10 C. The precipitated crystal was collected by filtration and spray-washed with water, and the obtained crystal was dried at 60 C. under reduced pressure. To the obtained crude product, 30 mL of toluene was added, and the mixture was dissolved under heating at 60 C. The resulting solution was left standing still at room temperature for 12 hours, and the precipitated crystal was collected by filtration, spray-washed with cooled toluene and dried at 60 C. under reduced pressure to obtain 87.7 g of Intermediate (d) (white powder, yield: 69.3%). The NMR measurement results of Intermediate (d) obtained are as follows. 1H NMR (300 MHz, d-DMSO) 8.74 (s, 1H), 7.99 (s, 1H), 6.87 (s, 4H), 5.35 (s, 2H), 1.24 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 59997-51-2, its application will become more common.

Reference:
Patent; FUJIFILM CORPORATION; US2011/17099; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 59997-51-2,Some common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4,4-Dimethyl-3-oxopentanenitrile (80 mmol, 10 g)At room temperature EtOH (200 mL)And stirred at 0 C, hydrazine monohydrate(160 mmol, 7.74 ml) was slowly added. Heated to 90 C and refluxed for 3 hours. After the reaction was completed, the reaction mixture was cooled at room temperature, and the solvent was removed under reduced pressure. Diluted with water, extracted with EtOAc Respectively. Sodium sulfate was added to the extracted organic solvent to remove residual water, and the resultant was separated by MPLC to obtain a red solid Was prepared in a yield of 57%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,4-Dimethyl-3-oxopentanenitrile, its application will become more common.

Reference:
Patent; Korea Research Institute of Chemical Technology; Lee, Kwang Ho; Choe, Gil Don; Park, Sang Jun; Lee, Na Li; Jung, Myung Eun; Kim, Sung Jin; Yang, Kyung Min; Lee, Ji Hee; (28 pag.)KR101726648; (2017); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H11NO

A mixture of 4-methoxyphenylhydrazine hydrochloride (3.5 g), 4,4-dimethyl-3-oxopentanenitrile (2.5 g), EtOH (30 mL), and AcOH (1 mL) was heated at the reflux temperature for 3 h, cooled to room temp., and poured into a mixture of Et2O (100 mL) and a 10% Na2CO3 solution (100 mL). The organic layer was washed with a saturated NaCl solution, dried (MgSO4) and concentrated under reduced pressure. The solid residue was washed with pentane to afford the desired pyrazole as a pale brown solid. (4.25g): 1H-NMR (DMSO-d6) delta 1.18 (s, 9H); 3.78 (s, 3H); 5.02 (br s, 2H); 5.34 (s, 1H); 6.99 (d, J=8 Hz, 2H); 7.42 (d, J=8 Hz, 2H).

According to the analysis of related databases, 59997-51-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Pharmaceuticals Corp.; EP1043995; (2006); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 59997-51-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-Bromosuccinimide(1.42g, 7.99mmol) was added to a solution of pivaloylacetonitrile(1.00g, 7.99mmol) in carbon tetrachloride(15mL), and the mixture was refluxed for 15 minutes. After the reaction mixture was cooled to room temperature, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by column chromatography on silica gel(n-hexane:ethyl acetate=4:1) to give the title compound(1.43g, 87.9%) as an yellowish brown oil.1H-NMR(CDCl3): delta 1.33(9H, s), 5.10(1H, s).

The synthetic route of 4,4-Dimethyl-3-oxopentanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Institute of Medicinal Molecular Design, Inc.; EP1555018; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 59997-51-2, A common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

128 mL of water was added to 50 g (357 mmol) of the intermediate (c), and the mixture was stirred at room temperature, 98.2 g (785 mmol) of pivaloyl acetonitrile was added to this suspension, 12M hydrochloric acid water was added dropwise at the same temperature so that the pH became 3, The mixture was heated to an internal temperature of 50 C. and stirred at the same temperature for 6 hours. After completion of the reaction, 8N aqueous solution of calcium hydroxide was added to neutralize the solution to pH 6.4. The crystals thus precipitated were collected by filtration and washed with water until the inner temperature became 10 C. The obtained crystals were dried under reduced pressure at 60 C. and 30 mL of toluene was added to the obtained crude product In addition, it was dissolved by heating to 60 C. The resulting solution was allowed to stand at room temperature for 12 hours, and the precipitated crystals were collected by filtration, washed with cold toluene, dried at 60 C. under reduced pressure,The obtained intermediate (d) was obtained in 87.7 g (white powder, yield 69.3%), and the NMR measurement results of the obtained intermediate (d) are as follows.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FUJIFILM Corporation; Tateishi, Keiichi; Sasaki, Hiroki; Nagata, Yoshiaki; (37 pag.)JP2017/61660; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 59997-51-2, These common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an aqueous solution of sodium hydroxide solution (0.84 g,21 mmol) in water (10 mL), pivaloylacetonitrile (1.25 g, 10 mmol) and hydroxylamine hydrochloride(0.76 g, 11 mmol) were added. The resulting solution was stirred at 50 C for 3 h. The reaction mixture was cooled and the resultant white crystalline solid was filtered, washed with water and dried to provide compound 25r as a white crystalline solid (1.23 g, yield 88%).

Statistics shows that 4,4-Dimethyl-3-oxopentanenitrile is playing an increasingly important role. we look forward to future research findings about 59997-51-2.

Reference:
Article; Li, Xingzhou; Zhou, Xinming; Zhang, Jing; Wang, Lili; Long, Long; Zheng, Zhibing; Li, Song; Zhong, Wu; Molecules; vol. 19; 2; (2014); p. 2004 – 2028;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 59997-51-2

At room temperature 4,4-dimethyl-3-oxopentanenitrile (J-ll) (1 equivalents, 5 g) was taken up in ethanol (100 mL), mixed with hydrazine hydrate (2 equivalents, 4.42 g) and refluxed for 3 h. The residue obtained after removal of the ethanol by distillation was taken up in water (100 mL) and extracted with ethyl acetate (300 mL). The combined organic phases were dried over sodium sulphate, the solvent was removed under vacuum and the product (J-lll) (5 g, 89 % yield) was obtained as a light red solid after recrystallisation from n- hexane (200 mL).

The synthetic route of 59997-51-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; WO2013/13815; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 59997-51-2, These common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step j03: At room temperature 4,4-dimethyl-3-oxopentanenitrile (J-II) (1 eq., 5 g) was taken up in EtOH (100 ml), mixed with hydrazine hydrate (2 eq., 4.42 g) and refluxed for 3 h. The residue obtained after removal of the EtOH by distillation was taken up in water (100 ml) and extracted with EE (300 ml). The combined organic phases were dried over sodium sulphate, the solvent was removed under vacuum and the product (J-III) (5 g, 89% yield) was obtained as a light red solid after recrystallisation from hexane (200 ml).

The synthetic route of 59997-51-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gruenenthal GmbH; US2012/115903; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 59997-51-2, A common heterocyclic compound, 59997-51-2, name is 4,4-Dimethyl-3-oxopentanenitrile, molecular formula is C7H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The cyanoxime ligand was obtained according to the modified procedure described by Fedorenko [38] using the pivaloylacetonitrile, NC-CH2-C(O)C(CH3)3, as starting material. Thus, 4.06 g (3.24 mM) of the latter were dissolved in 75 mL of CH3OH to which 2.46 g (3.57 mM; 1.10 times excess with respect to the acetonitrile) of NaNO2 in 150 mL of H2O were added. Then 2.80 mL of glacial acetic acid were added dropwise within 2 h; this mixture precooled to -2 C under the N2 blanket. The mixture was allowed to stay overnight at 0 C and then 100 mL of water and 5 drops of HCl (conc.) were added at once, which resulted in the mixture discoloration and the quick formation of the HPiCO as a white precipitate.The latter was filtered, washed twice with 10 mL ofwater and dried in a desiccator under vacuum, yielding 3.54 g ofthe cyanoxime. An additional portion of 1.07 g of HPiCO can berecovered from the mother liquor using extraction with 3 portions(50 mL each) of ether. The combined total yield is 92% (4.61 g); the compound melts at 150 C followed by rapid decomposition. TheNMR spectra in dmso-d6 (ppm): 1H – 14.88 (1H, slightly broadenedsinglet, oxime), 1.28 (9H, singlet, three methyl groups); 13C – 198.17(CO), 132.10 – oxime, 109.19 (CN), 44.29 – C(CH3)3, 27.03-methylgroups. The bands in the IR-spectrum (KBr, cm1): 3275, strong – m(OH); 2985, 2944, 2924, 2877 all medium – mas, ms (CH); 2231, weak- m (C?N); 1674, strong – m (CO); 1590, weak – m (CN); 1054,1030, strong – m (NAO). The compound represents a whitecrystalline solid not soluble in water, sparingly soluble in hexaneand cyclohexane, and well soluble in alcohols, acetone andchlorohydrocarbons.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mann, Alexandra; Gerasimchuk, Nikolay; Silchenko, Svitlana; Inorganica Chimica Acta; vol. 440; (2016); p. 118 – 128;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts