Category: 591769-05-0

Application of 591769-05-0,Some common heterocyclic compound, 591769-05-0, name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-(lH-pyrazol-4-yl)pynOlo[l,2-b]pyridazine-3-carbonitrile 16a (60 mg, 0.287 mmol) in DMF (1.5 mL) was added 3-cyclopentylacrylonitrile (109 mg, 0.717 mmol), 2,3,4,6,7,8,9, 10-octahydropyrimido[l,2-a]azepine (0.270 mL, 1.772 mmol) and heated with stirring at 50 °C for 3 h. The reaction mixture was cooled to RT and concentrated in vacuum to dryness. The residue obtained was purified by combiflash column chromatography [silica gel, 4 g eluting with hexanes/ethyl acetate (1 :0 to 2:1)] to give 4-(l-(2-cyano-l-cyclopentylethyl)-lH- pyrazol-4-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile 16b (56 mg, 59percent, Rf = 0.42 with hexanes/ethyl acetate = 2:1) as a yellow solid; 1H NMR (300 MHz, OMSO-d6) delta 8.80 (d, J= 0.6 Hz, 1H), 8.48 (s, 1H), 8.31 (s, 1H), 8.19 (t, J= 2.1 Hz, 1H), 7.13 (d, J= 2.0 Hz, 2H), 4.64 (td, J = 9.0, 4.8 Hz, 1H), 3.29 – 3.21 (m, 2H), 2.48 – 2.37 (m, 1H), 1.91 – 1.11 (m, 8H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Cyclopentylacrylonitrile, its application will become more common.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; WU, Minwan; WO2011/150356; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 591769-05-0, name is 3-Cyclopentylacrylonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Step 2. (3R)- and (3S)-3-Cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H- pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile. To a solution of 4-(1H-pyrazol- 4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidine (15.0 g, 0.0476 mol) in ACN (300 mL) was added 3-cyclopentylacrylonitrile (15 g, 0.12 mol) (as a mixture of cis and trans isomers), followed by DBU (15 mL, 0.10 mol). The resulting mixture was stirred at room temperature overnight. The ACN was evaporated. The mixture was diluted with ethyl acetate, and the solution was washed with 1.0 N HCl. The aqueous layer was back-extracted with three portions of ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel chromatography (gradient of ethyl acetate/hexanes) to yield a viscous clear syrup, which was dissolved in ethanol and evaporated several times to remove ethyl acetate, to afford 19.4 g of racemic adduct (93percent). The enantiomers were separated by preparative-HPLC, (OD-H column, 15percent ethanol/hexanes) and used separately in the next step to generate their corresponding final product. The final products (see Step 3) stemming from each of the separated enantiomers were found to be active JAK inhibitors; however, the final product stemming from the second peak to elute from the preparative-HPLC was more active than its enantiomer. The products may be isolated by preparative HPLC or other means known to those of skill in the art for use in Step 3 below. 1H NMR (300 MHz, CDCl3): delta 8.85 (s, 1H), 8.32 (s, 2H), 7.39 (d, 1H), 6.80 (d, 1H), 5.68 (s, 2H), 4.26 (dt, 1H), 3.54 (t, 2H), 3.14 (dd, 1H), 2.95 (dd, 1H), 2.67-2.50 (m, 1H), 2.03- 1.88 (m, 1H), 1.80-1.15 (m, 7H), 0.92 (t, 2H),?0.06 (s, 9H); MS(ES): 437 (M+1).

The synthetic route of 591769-05-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACERTA PHARMA B.V.; HAMDY, Ahmed; ROTHBAUM, Wayne; IZUMI, Raquel; LANNUTTI, Brian; COVEY, Todd; ULRICH, Roger; JOHNSON, Dave; BARF, Tjeerd; KAPTEIN, Allard; (745 pag.)WO2016/24232; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In an article, author is Zhang, Yueteng, once mentioned the application of 591769-05-0, Formula: C8H11N, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, molecular weight is 121.18, MDL number is MFCD11857755, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.

Organophotocatalytic dearomatization of indoles, pyrroles and benzo(thio)furans via a Giese-type transformation

Dearomatisation of indoles allows efficient access to indolines, but often is incompatible with electron-withdrawing substituents. Here a photoredox Giese-type dearomatisation of indoles yields 2,3-disubstituted indolines bearing electron-withdrawing groups. Accessing fascinating organic and biological significant indolines via dearomatization of indoles represents one of the most efficient approaches. However, it has been difficult for the dearomatization of the electron deficient indoles. Here we report the studies leading to developing a photoredox mediated Giese-type transformation strategy for the dearomatization of the indoles. The reaction has been implemented for chemoselectively breaking indolyl C=C bonds embedded in the aromatic system. The synthetic power of this strategy has been demonstrated by using structurally diverse indoles bearing common electron-withdrawing groups including (thio)ester, amide, ketone, nitrile and even aromatics at either C-2 or C-3 positions and ubiquitous carboxylic acids as radical coupling partner with high trans-stereoselectivity (>20:1 dr). This manifold can also be applied to other aromatic heterocycles including pyrroles, benzofurans and benzothiophenes. Furthermore, enantioselective dearomatization of indoles has been achieved by a chiral camphorsultam auxiliary with high diastereoselectivity.

If you are interested in 591769-05-0, you can contact me at any time and look forward to more communication. Formula: C8H11N.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, belongs to nitriles-buliding-blocks compound, is a common compound. In a patnet, author is Satyanarayana, Iddum, once mentioned the new application about 591769-05-0, Recommanded Product: 3-Cyclopentylacrylonitrile.

Nitromethane as a surrogate cyanating agent: 7-N,N-dimethylamino-4-hydroxycoumarin-catalyzed, metal-free synthesis of alpha-iminonitriles

An efficient, metal/alkali-cyanide free approach for the synthesis of alpha-iminonitriles via kinetically controlled, base-mediated and 1,3-diketone-catalyzed reaction is reported. The preparation of target compounds was realized by condensation of substituted anilines and aldehydes in nitromethane as a surrogate cyanating agent and as a solvent. This strategy was further improved by replacing aldehydes and nitromethane with beta-nitrostyrene and ethanol, respectively, rendering the methodology greener. The catalytic role played by 1,3-diketones such as 7-N,N-dimethylamino-4-hydroxycoumarin in this three-component reaction was investigated, and a plausible mechanism was proposed based on control experiments.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 591769-05-0. The above is the message from the blog manager. Recommanded Product: 3-Cyclopentylacrylonitrile.

591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, belongs to nitriles-buliding-blocks compound, is a common compound. In a patnet, author is Mensah, Alfred, once mentioned the new application about 591769-05-0, Computed Properties of C8H11N.

Bioactive Icariin/beta-CD-IC/Bacterial Cellulose with Enhanced Biomedical Potential

A super bioactive antibacterial hydrogel, Icariin-beta-CD-inclusion complex/Bacterial cellulose and an equally capable counterpart Icariin-Bacterial cellulose (ICBC) were successfully produced with excellent antioxidant properties. The highly porous hydrogels demonstrated very high fluid/liquid absorption capability and were functionally active as Fourier Transform Infrared Spectrometer (FTIR) test confirmed the existence of abundant hydroxyls (-OH stretching), carboxylic acids (-CH2/C-O stretching), Alkyne/nitrile (C equivalent to C/C equivalent to N stretching with triple bonds) and phenol (C-H/N-O symmetric stretching) functional groups. Scanning electron microscope (SEM) and X-ray diffraction (XRD) tests confirmed a successful beta-CD-inclusion complexation with Icariin with a great potential for sustained and controlled drug release. In vitro drug release test results indicated a systemic and controlled release of the drug (Icariin) from the internal cavities of the beta-CD inclusion complex incorporated inside the BC matrix with high Icariin (drug) release rates. Impressive inactivation rates against Gram-negative bacteria Escherichia coli ATCC 8099 and gram-positive bacteria Staphylococcus aureus ATCC 6538; >99.19% and >98.89% respectively were recorded, as the materials proved to be non-toxic on L929 cells in the in vitro cytotoxicity test results. The materials with promising versatile multipurpose administration of Icariin for wound dressing (as wound dressers), can also be executed as implants for tissue regeneration, as well as face-mask for cosmetic purposes.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 591769-05-0. The above is the message from the blog manager. Computed Properties of C8H11N.

591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, belongs to nitriles-buliding-blocks compound, is a common compound. In a patnet, author is Nakakohara, Hiroshi, once mentioned the new application about 591769-05-0, Formula: C8H11N.

Synthetic Study on Acremoxanthone A, Part 2: Model Study on the EFG Xanthone Moiety through a Nitrile Oxide Cycloaddition-SNAr Sequence

Toward a total synthesis of acremoxanthone A, we report a model study on the construction of the EFG ring system. The key steps include (1) an intermolecular 1,3-dipolar cycloaddition of an aryl nitrile oxide with a dienone, and (2) an SNAr reaction for construction of the F ring.

If you¡¯re interested in learning more about 591769-05-0. The above is the message from the blog manager. Formula: C8H11N.

In an article, author is Yang, Wenlong, once mentioned the application of 591769-05-0, Computed Properties of C8H11N, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N, molecular weight is 121.18, MDL number is MFCD11857755, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.

Biotransformation of flonicamid and sulfoxaflor by multifunctional bacterium Ensifer meliloti CGMCC 7333

Flonicamid is a novel, selective, systemic pyridinecarboxamide insecticide that effectively controls hemipterous pests. Sulfoxaflor, a sulfoximine insecticide, effectively controls many sap-feeding insect pests. Ensifer meliloti CGMCC 7333 transforms flonicamid into N-(4-trifluoromethylnicotinoyl) glycinamide (TFNG-AM). Resting cells of E. meliloti CGMCC 7333 (optical density at 600 nm [OD600] = 5) transformed 67.20% of the flonicamid in a 200-mg/L solution within 96 h. E. meliloti CGMCC 7333 transforms sulfoxaflor into N-(methyl(oxido){1-[6-(trifluoromethyl) pyridin-3-yl] ethyl}-k4-sulfanylidene) urea (X11719474). E. meliloti CGMCC 7333 resting cells (OD600 = 5) transformed 89.36% of the sulfoxaflor in a 200 mg/L solution within 96 h. On inoculating 2 mL of E. meliloti CGMCC 7333 (OD600 = 10) into soil containing 80 mg/kg flonicamid, 91.1% of the flonicamid was transformed within 9 d (half-life 2.6 d). On inoculating 2 mL of E. meliloti CGMCC 7333 (OD600 = 10) into soil containing 80 mg/kg sulfoxaflor, 83.9% of the sulfoxaflor was transformed within 9 d (half-life 3.4 d). Recombinant Escherichia coli harboring the E. meliloti CGMCC 7333 nitrile hydratase (NHase)-encoding gene and NHase both showed the ability to transform flonicamid or sulfoxaflor into their corresponding amides, TFNG-AM and X11719474, respectively. These findings may help develop a bioremediation agent for the elimination of flonicamid and sulfoxaflor contamination.

If you are interested in 591769-05-0, you can contact me at any time and look forward to more communication. Computed Properties of C8H11N.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, SMILES is N#C/C=C/C1CCCC1, in an article , author is Sogawa, Hiromitsu, once mentioned of 591769-05-0, Application In Synthesis of 3-Cyclopentylacrylonitrile.

Aliphatic ditopic nitrile N-oxide crosslinker: Synthesis, chemical stability, and catalyst-free crosslinking reactions

Nitrile N-oxides are useful reagents and crosslinkers for catalyst- and byproduct-free 1,3-dipolar cycloaddition reactions. The stability of nitrile N-oxides can be enhanced by introducing bulky substituents, whereas their reactivity decreases concomitantly. Herein, an isolatable aliphatic ditopic nitrile N-oxide was synthesized and applied to catalyst-free crosslinking of unsaturated bond-containing polymers. By decreasing the steric hindrance around the nitrile N-oxide moiety compared with a related crosslinker previously developed in our group, the operating temperature of the crosslinking reaction could be lowered. Efficient crosslinking of natural rubber (NR) was achieved at 40 degrees C in chloroform to give crosslinked NR without formation of byproducts. Furthermore, polyacrylonitrile and nitrile butadiene rubber can be used as the scaffolds for efficient catalyst- and solvent-free crosslinking reactions.

Interested yet? Read on for other articles about 591769-05-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 3-Cyclopentylacrylonitrile.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, molecular formula is C8H11N. In an article, author is Hanif, Hani Mohd,once mentioned of 591769-05-0, Safety of 3-Cyclopentylacrylonitrile.

Evaluating the efficacy of a newly developed palm-based process aid on nitrile rubber composites

The exploration of bio-based process aid is still ongoing in the effort to replace petroleum-based process oil. In this study, the efficacy of a newly developed palm-based process aid (Bio) on nitrile rubber (NBR) composites was investigated by varying its concentration from 0.0 to 10.0 phr. A comparison was made against a commercial oil (CO), i.e. naphthenic oil in terms of Mooney viscosity, cure characteristics, morphology, physical, and chemical properties. Results revealed that the use of Bio as process aid improves the processability of rubber by lowering the Mooney viscosity, enhancing filler dispersion, and lowering loss tangent values. Tensile properties and compression sets of CO-NBR composites were slightly better compared to Bio-NBR composites. Interestingly, Bio-NBR composites showed better ageing properties, especially at higher process aid content. Higher retentions of tensile strength and elongation at break and lower compression sets of aged Bio-NBR compared to CO-NBR composites were observed, which are possibly contributed by the good compatibility of Bio with aged rubber. Thermogravimetric analysis showed that the thermal stability of Bio-NBR composites were slightly better than CO-NBR composites. Based on these findings, the use of Bio (>= 7.5 phr) as process aid significantly improved the processability of rubber with some enhancement in ageing properties of composites that is desirable and ideal for various applications such as for the production of automotive components.

Interested yet? Keep reading other articles of 591769-05-0, you can contact me at any time and look forward to more communication. Safety of 3-Cyclopentylacrylonitrile.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 591769-05-0, Name is 3-Cyclopentylacrylonitrile, SMILES is N#C/C=C/C1CCCC1, in an article , author is Ansel, Annabel Q., once mentioned of 591769-05-0, Safety of 3-Cyclopentylacrylonitrile.

Combined Cyanoborylation, C-H Activation Strategy for Styrene Functionalization

A one-pot multicomponent copper-catalyzed protocol for borylation/ortho-cyanation of styrene derivatives followed by a Suzuki-Miyaura coupling provides a platform to explore the factors that control the selectivity between distal or proximal functionalization of arenes. The development of divergent nitrile-directed C-H functionalization (acetoxylation, pivalation, and methoxylation) offers an effective approach to rapidly increase synthetic complexity. Finally, the development of a mild reductive decyanation allows a traceless method to access functionalized biaryl motifs.

Interested yet? Read on for other articles about 591769-05-0, you can contact me at any time and look forward to more communication. Safety of 3-Cyclopentylacrylonitrile.