Category: 59146-60-0

Lauria, Antonino published the artcileAnnelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems, Safety of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, the main research area is sulfanylmethyleneamino ester aminocyanopyrrole heterocyclization; pyrrolopyrimidine preparation anticancer; imidazopyrrolopyrimidine preparation anticancer.

The efficient one-pot synthesis of several tricyclic systems, e.g., I, obtained from the reaction of substituted 2-amino-3-cyanopyrroles and 3-amino-4-cyanopyrroles with BMMAs, is reported. The duration and yields of the reaction strongly depend on the reactivity of the starting pyrrole and on the size of the ring to be formed. Mechanist features of the reaction were investigated and proposed by studying also the reactivity of a 3-aminopyrrole-2,4-dicyano substituted. The method reported represents an example of the use of BMMA reagents in combination with pyrrole derivatives and allowed an easy and versatile entry to a large number of pyrrolo-pyrimidines further annelated with nitrogen heterocycles of different sizes. These polycondensed heterocycles possessed the requisite to interact with DNA.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, Safety of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Girgis, Nabih S. published the artcilePhosphorus pentoxide in organic synthesis. VII. Synthesis of 3-aryl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imines, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, the main research area is pyrrolopyrimidinimine aryl preparation antineoplastic; phosphorus pentoxide cyclization acetylaminopyrrolecarbonitrile; pyrrolecarbonitrile acetylamino phosphorus pentoxide cyclization; arylpyrrolopyrimidinimine preparation antineoplastic; fungicide arylpyrrolopyrimidinimine preparation; insecticide arylpyrrolopyrimidinimine preparation; plant regulator arylpyrrolopyrimidinimine preparation; pyrimidinimine arylpyrrolo antineoplastic preparation.

Anhydrous RR1C6H3NH2.HCl (R = H, R1 = H, 4-Cl, 2-F, 4-F, 3-Me, 4-Me, 4-Et, 4-Bu; R = 2-Cl, R1 = 4-Cl; R = 2-Me, R1 = 4-Me) reacted with pyrroles I [R2 = H, CHMeEt, CH2Ph; R3 = Me, Ph), P2O5, and N,N-dimethylcyclohexylamine at 150-180° to give the title compounds II, which were inactive against P388 lymphocytic leukemia. However, II (R = R1 = R2 = H, R3 = Me) was active against the plant louse, II (R = R2 = H, R1 = 4-F, R3 = Ph) was a plant regulator, and II (R = H, R1 = F, R2 = CHMeEt, R3 = Me) was a fungicide against Cercospora on peanut at 200 ppm.

Liebigs Annalen der Chemie published new progress about Antitumor agents. 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Andersen, K. E. published the artcileOxadiazoles as bioisosteric transformations of carboxylic functionalities. Part I, COA of Formula: C6H7N3, the main research area is pyrazolopyrimidine pyrrolopyrimidine oxadiazolylpyrazolopyrimidine preparation benzodiazepine receptor.

Cyclocondensation of aminopyrazoles with appropriate 3-(dimethylamino)-1-aryl-2-propen-1-ones gave 51-86% pyrazolo[1,5-a]pyrimidines I (R1 = cyano, CO2Et, R2 = 4-F3CC6H4, Ph, 3-thienyl, etc.). Reaction of nitriles I with hydroxylamine in aqueous ethanol gave crude 56-93% amidoximes which on heating with an acid chloride or anhydride afforded 65-81% oxadiazole derivatives II (R3 = Me, cyclopropyl, CF3, R2 = same). Some pyrrolopyrimidines were also prepared and the prepared compounds were tested as benzodiazepine receptors.

European Journal of Medicinal Chemistry published new progress about Benzodiazepine receptors Role: RCT (Reactant), RACT (Reactant or Reagent). 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, COA of Formula: C6H7N3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts