Category: 58168-20-0

Synthesis of strontium ranelate, an antiosteoporosis drug was written by Ding, Xiangyu;Jiang, Ye;Jia, Xiangman;Liu, Fenghua. And the article was included in Zhongguo Yaoxue Zazhi (Beijing, China) in 2008.SDS of cas: 58168-20-0 This article mentions the following:

The synthesis route of strontium ranelate, an antiosteoporosis drug was studied. Strontium ranelate was synthesized from citric acid via decarboxylation, esterification, cyclization, alkylation, hydrolysis and salification. The structure of strontium ranelate was confirmed by IR, ¹H-NMR, ¹³C-NMR and the total yield was 42.6% approx. The synthesis route was simple, low cost and could be used in industry. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0SDS of cas: 58168-20-0).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. SDS of cas: 58168-20-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of intermediate of strontium ranelate by using ionic liquid as phase transfer catalyst was written by Li, Cen;Jiang, Yi;Jiang, Ye;Liu, Feng-hua. And the article was included in Huaxi Yaoxue Zazhi in 2009.Application of 58168-20-0 This article mentions the following:

OBJECTIVE: To study a new catalytic way using ionic liquid as phase transfer catalyst for the synthesis of intermediate of strontium ranelate. METHODS: Tetra-Et ester of 5-aminothiophene was synthesized from 5-aminothiophene using Et bromoacetate as alkylating reagent and ionic liquid as phase transfer catalyst. RESULTS and CONCLUSION: The proposed method was not only suitable for industrial manufacture with high yield of 81%, but also could cut down the discharging of pollutants. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Application of 58168-20-0).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Application of 58168-20-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of 2-azo-3-cyano-5-carbethoxy thiophene derivatives and their application on polyester fibers was written by Sabnis, Ram W.;Rangnekar, Dinesh W.. And the article was included in Journal of Chemical Technology and Biotechnology in 1990.Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate This article mentions the following:

Synthesis of 2-(hetaryl or aryl)-azo thiophene derivatives was achieved by diazotization of Et 2-amino-3-cyano-5-carbethoxythiophene-4-acetate (I) using nitrosylsulfuric acid and coupling with suitable heterocyclic hydroxy and N,N-dialkyl-substituted aryl amines. I was synthesized in one pot and in excellent yield from di-Et acetonedicarboxylate, S and malonitrile, using HNEt₂ as a catalyst, following the Gewald synthesis. The spectral properties of these dyes were studied. The dyes when applied as disperse dyes on polyester fibers gave excellent results. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reactivity of 2-aminothiophenes. Application to synthesis of thieno[2,3-b]pyrroles was written by Wierzbicki, Michel;Cagniant, Denise;Cagniant, Paul. And the article was included in Bulletin de la Societe Chimique de France in 1975.Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate This article mentions the following:

Thienopyrroles I (R = H, Ac; R1 = OH, NH2; R2 = CH2CO2Et, Me; R3 = CO2Et, Ac) were prepared by treating the thiophenes II (R4 = H; R5 = CO2Et, CN) with BrCH2CO2Et and Dieckmann reaction of II (R4 = CH2CO2Et). I (R1 = OH) were alkylated with BrCH2CO2Et or acetylated. I (R2 = NH2) were acetylated and diazotized. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis and dyeing characteristics of ethyl 1-(2-acetamido-3-cyano-5-carbethoxythiophen-4-yl)glyoxalate(aryl)hydrazones was written by Sabnis, R. W.;Rangnekar, D. W.. And the article was included in Indian Journal of Fibre & Textile Research in 1992.Formula: C12H14N2O4S This article mentions the following:

Five monoazo disperse dyes, Et 1-(2-acetamido-3-cyano-5-carbethoxythiophen-4-yl)glyoxalate-(aryl)hydrazones, were prepared and their dyeing performance on polyester fibers was assessed. The dyeings on polyester had orange red and bright red shades with low pickup, moderate light fastness and good sublimation fastness. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Formula: C12H14N2O4S).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Formula: C12H14N2O4S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts