Category: 57775-06-1

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57775-06-1 as follows. name: 2-(2-Bromophenyl)-2-methylpropanenitrile

General procedure: To a screw-capped vial (25 mL) were added NaOH (400 mg, 10 mmol), tert-butanol (tBuOH, 10 mL) and 3a (1.12 g, 5 mmol). The vial was sealed with cap and allowed to stir at 100 °C. The reaction was monitored by TLC every hour until the complete consumption of 3a. After total conversion of 3a, the reaction was diluted with CH2Cl2, filtered through a thin Celite pad to remove salt, and concentrated in vacuo. The residue was isolated through a short flash column chromatography by using ethyl acetate as eluent to give the pure compound 1a in 92percent isolated yield; White solid, mp: 73?74 °C; IR (KBr): 3472, 2977, 2932, 1669, 1605, 1468, 1427, 1390, 1360, 1022, 756 cm-1; 1H NMR (600 MHz, CDCl3): delta 7.60 (dd, J1 = 7.8 Hz, J2 = 1.2 Hz, 1H), 7.49 (dd, J1 = 7.8 Hz, J2 = 1.2 Hz, 1H), 7.34 (td, J1 = 7.8 Hz, J2 = 1.2 Hz, 1H), 7.14 (td, J1 = 7.8 Hz, J2 = 1.8 Hz, 1H), 5.72 (br, 1H), 5.23 (br, 1H), 1.65 (s, 6H); 13C NMR (150 MHz, CDCl3): delta 179.0, 143.0, 134.8, 128.6, 127.7, 127.6, 124.1, 48.3, 26.4; HRMS: C10H12BrNO calculated 241.0102, found 241.0098; Registry Number: [173026-22-7]. Compounds 1b?1q were obtained according to this procedure. The synthetic methods for all the nitrile compounds 3 were prepared according to our previous report.2

According to the analysis of related databases, 57775-06-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jhan, Yu-Huei; Kang, Ting-Wei; Hsieh, Jen-Chieh; Tetrahedron Letters; vol. 54; 9; (2013); p. 1155 – 1159;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

57775-06-1, name is 2-(2-Bromophenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-(2-Bromophenyl)-2-methylpropanenitrile

To a solution of 2-(2- bromophenyl)-2-methylpropanenitrile (4.0 g, 17.8 mmol), in dry THF (40 mL) was added borane-dimethyl sulfide (5.08 mL, 53.5 mmol) at 0 °C and the reaction mixture was slowly brought to rt, stirred for 1 h and then, heated to reflux for 18 h. The solvent was removed and quenched with MeOH, and heated to reflux for 18 h. The reaction was concentrated and the residue was dissolved in EtOAc, washed with H2O, brine, dried (Na2SO4), flltered and concentrated to give 4.0 g of 103 A as a white solid. MS (ESI) m/z: 230.2 (M+H)+.

The synthetic route of 57775-06-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; WO2013/56034; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts