Category: 57381-56-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-56-3 as follows. category: nitriles-buliding-blocks

General procedure: A solution of 2 M Na2CO3 (10 mL) was added under nitrogen to a 2-bromoaniline (10 mmol) in 60 mL dioxane. After 5 min stirring at 75 C, Pd[P(C6H5)3]4 was added followed by (10 mmol) of a 2-cyanophenylboronic acid pinacol ester. The reaction was stirred 8 h at 100 C. After cooling to rt the mixture was vacuum concentrated to half of its initial volume and extracted with CH2Cl2 (30 mL) and water (30 mL). The aqueous phase was extracted with CH2Cl2 (3¡Á20 mL). The combined organic layers were washed with brine, dried over Na2SO4 and evaporated. The solid crystallized upon concentration.

According to the analysis of related databases, 57381-56-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nguyen, Phuhai; Oumata, Nassima; Soubigou, Flavie; Evrard, Justine; Desban, Nathalie; Lemoine, Pascale; Bouaziz, Serge; Blondel, Marc; Voisset, Cecile; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 363 – 371;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

57381-56-3, name is 2-Chloro-5-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H3ClFN

Preparation 13: 1-[2-ChIoro-5-(4-methyI-piperazin-1-yl)-phenyl]-ethanone; STEP A; A mixture of 2-chloro-5-fluoro-benzonitrile (1 g, 6.43 mmol), K2CO3 (2.66 g, 19.3 mmol) and 1-methyl-piperazine (1.02 g, 10.26 mmol) in DMSO (14 ml) was stirred at 1000C overnight and then further 1-methyl-piperazine (1.02 g, 10.26 mmol) was added. The mixture was stirred at 1000C overnight and then partitioned between water and Et2O. The organic phase was extracted with 1 M HCI and the aqueous layer was brought to basic conditions with NH4OH and extracted with DCM. The organic phase was dried over Na2SO4 and evaporated in vacuo to give 1 g of 2- chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile. Y= 66%

The synthetic route of 57381-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts