Category: 57381-51-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Chloro-2-fluorobenzonitrile

Cyclopentylamine and potassium carbonate were added to a DMF solution of 4-chloro-2-fluorobenzonitrile, followed by stirring at 100C for 12 hours. By post-treating the reaction liquid, 4-chloro-2-(cyclopentylamino)benzonitrile was obtained.

According to the analysis of related databases, 57381-51-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 57381-51-8

General procedure: Into an oven-dried flask equipped with a magnetic stir bar was added aryl fluoride (1.00 g, 1.0 eq.), Na2S (1.1 eq.) and DMF (5 mL) under argon. The reaction mixture was stirred at room temperature for 1 h. Then 1 M NaOH (50 mL) was added and was washed with CH2Cl2 (2 x 25 mL). The aqueous layer was acidified to pH ~ 1-2 with 6 N HCl and extracted with CH2Cl2 (2 x 50 mL). The combined organic layer was washed with brine (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure to provide a crude residue. To the residue was added 10% HCl (40 mL) and cooled with an ice-water bath. Then zinc dust (4 g) was added and the mixture was stirred for 1 h. Then EtOAc (100 mL) was added and the mixture was stirred for an additional 30 minutes. The organic layer was separated and washed with water (40 mL) and brine (40 mL), dried over MgSO4, filtered and concentrated to provide the desired product with satisfactory purity.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57381-51-8.

Application of 57381-51-8,Some common heterocyclic compound, 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 13: 1-(4-chloro-2-(piperidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Preparation of 4-chloro-2-(piperidin-1-yl)benzonitrile 16ah (scheme 8) To commercially available 2-fluoro-4-chlorobenzonitrile (2.2 g, 12.87 mmol) piperidine (4equiv., 5.6 ml) was added and the solution was heated at 80C overnight. The reaction was evaporated and to the residue water was added and the solid material was filtrated, washed with water and dried obtaining 3 g of a pale yellow solid. Yield = 97% 1HNMR (DMSO, 200 MHz) delta 1.54 (2H, m), 1.65 (4H, m), 3.14 (4H, m), 7.09 (1H, dd, J = 8.2 Hz, J’ = 2 Hz), 7.14 (1H, m), 7.69 (1H, d, J = 8.4 Hz)

The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 57381-51-8, The chemical industry reduces the impact on the environment during synthesis 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

c 2-[3-Amino-1-(2-oxazolyl)propoxy]-4-chlorobenzonitrile oxalate To a solution of the product from Example 56(b) (160 mg) in dimethylformamide (2 ml) was added sodium hydride (76 mg of a 60% dispersion in mineral oil) and the reaction stirred for 1 h. Solid 4-chloro-2-fluoro-benzonitrile (296 mg) was added and the reaction stirred for 2 h. Water was added and the solution extracted with diethyl ether. The organic extract was separated, dried (sodium sulphate) and the solvent removed in vacuo. The residue was taken up in tetrahydrofuran (4 ml) and triphenylphosphine (283 mg) added. After 5 minutes, water (1 ml) was added and the reaction stirred for 16 h. Further water (2 ml) was added and the reaction stirred at 55 C. for 3 h and then 48 h at room temperature. The reaction was poured into ethyl acetate/aqueous 1N sodium hydroxide. The organic extract was separated, dried (sodium sulphate) and the solvent removed in vacuo. Purification by RP-HPLC afforded the free base of the title product (20 mg) as a white solid. This was taken up in diethylether/dichloromethane (1:1) and a solution of oxalic acid (15 mg) in diethyl ether (1 ml) added. The resulting solid was filtered off and dried in vacuo to yield 4 mg of the title product as a hydroscopic white solid. MS APCI+ve m/z 278 [(M+H)+]. 1H NMR 400 MHz (d4-MeOH) 7.87 (1H, s), 7.66 (1H, d), 7.34 (1H, s), 7.22 (1H, d), 7.17 (1H, s), 3.21 (1H, m), 3.10 (1H, m), 2.73 (1H, ddd), 2.46 (1H, ddd).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Mete, Antonio; Pimm, Austen; US2003/158185; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 57381-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57381-51-8 name is 4-Chloro-2-fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Chloro-2-fluorobenzonitrile (200 mg, 1 .29 mmol) and Na2S (1 10 mg, 1 .41 mmol) were added into a microwave vial, DMF (1 mL) was charged into the mixture before stirring for 1 h at room temperature. 1 M NaOH solution was charged to pH 12 then washed by Et20 (3 x 10 mL, acedified mixture with 1 M HCI to pH 1 -2 and extracted with Et20 (3 x 10 mL), the combined extracts were washed by water (30 mL) and brine (20 mL), dried by MgS04, concentrate in vacuo to give a yellow solid (156 mg, 72%). H NMR (500 MHz, CDCI3) delta 4.14 (1 H, s, SH), 7.21 (1 H, d, J = 8.4 Hz, H-Ar), 7.42 (1 H, s, H-Ar), 7.52 (1 H, d, J = 8.3 Hz, H-Ar).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-2-fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; CHESSARI, Gianni; HOWARD, Steven; BUCK, Ildiko Maria; CONS, Benjamin David; JOHNSON, Christopher Norbert; HOLVEY, Rhian Sara; REES, David Charles; ST. DENIS, Jeffrey David; TAMANINI, Emiliano; GOLDING, Bernard Thomas; HARDCASTLE, Ian Robert; CANO, Celine Florence; MILLER, Duncan Charles; CULLY, Sarah; NOBLE, Martin Edward Maentylae; OSBORNE, James Daniel; PEACH, Joanne; LEWIS, Arwel; HIRST, Kim Louise; WHITTAKER, Benjamin Paul; WATSON, David Wyn; MITCHELL, Dale Robert; (293 pag.)WO2017/55860; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H3ClFN

4-Chloro-2-fluoro-benzonitrile (8.0 g, 50.4 mmol), NaHS^FbO (50.4 mmol, 4.006 g) and DMF (30 mL) were stirred on an ice bath for 1 h. The mixture was partitioned between diethyl ether and HC1 (0.5 M), the organic phase was then extracted with NaOH (2 M, 50 ml) and the aqueous phase was concentrated a little, then acidified with HC1 which gave a precipitate that was isolated and dried to afford the title compound (5.1 g, 59 %). ‘H NMR (400 MHz, Chloroform-^) d 7.53 (d, j= 8.4 Hz, 1H), 7.43 (d, j= 1.7 Hz, 1H), 7.22 (dd, j= 8.4, 1.8 Hz, 1H), 4.15 (s, 1H).

The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; (118 pag.)WO2019/137971; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H3ClFN

a 4-Chloro-2-[(3-Hydroxy-1-Phenylpropyl)Amino]Benzonitrile A mixture of 3-amino-3-phenylpropanol (1 g, 6.6 mmol) and 4-chloro-2-fluorobenzonitrile (1 g, 6.4 mmol) in diisopropylethylamine (1.2 ml, 6.9 mmol) was heated at 140 C. for 5 h. The crude reaction mixture was cooled to room temperature and applied to a silica column. The title compound was isolated as a colourless solid (1.1 g, 58%) by elution with 20% diethyl ether/isohexane. MS APCI+vem/z287 ([M+H]+).

The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cheshire, David; Connolly, Stephen; Cox, David; Millichip, Ian; US2003/73685; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts