Electric Literature of 57381-41-6, A common heterocyclic compound, 57381-41-6, name is 2,5-Dibromobenzonitrile, molecular formula is C7H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 5.00g (19.16mmol) 2,5- dibromobenzene cyanide, 24g (76.65mmol) 1- (4- methoxybenzyl) pyrazole boronic ester, 11.64g (76.65mmol) of cesium fluoride, 1.11g ( 0.96 mmol) tetrakis (triphenylphosphine) palladium, ethylene glycol dimethyl ether was added to 300mL 500mL three bottles, sealed, vacuum, nitrogen atmosphere, for 6 hours at 100 .After stopping the reaction, extracted with dichloromethane, washed with water, dried over anhydrous sodium sulfate, filtered, and evaporated under reduced pressure, purified by silica gel column chromatography purification, 2,5-bis (1- (4-methoxybenzyl ) lH-pyrazol-4-yl) benzyl cyanide 6.5g, yield 71.33%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Beijing industry university; Li, Jianrong; He, Tao; Xie, Yabo; Bai, Jinquan; (10 pag.)CN105541717; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts