Category: 57381-34-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Chloro-2-fluorobenzonitrile

To a stirred [0C] solution of 1,1, 1,3, 3, [3-HEXAMETHYLDISILAZANE] (63 mL, 0.3 mmol) in dry diethyl ether was added dropwise n-Butyl lithium (2M in hexanes, 119 mL, 0.3 [MMOL).] A white suspension formed, to which was added [2-FLUORO-5-CHLOROBENZONITRILE (21.] 0 g, 0.14 mmol) over 5 min. The resultant orange mixture was allowed to warm to r. t. and stirred for 2h. The mixture was cooled to 0C and the reaction quenched by the addition [OF 3M HCI] (aq. ) (240 mL). The mixture was stirred for [0.] 5h before water (600 mL) was added. The purple organic layer was discarded and the aqueous layer basified to pH 14 with satd. NaOH (aq. ). The aqueous layer was extracted with [CHC13] [(5X100] mL) and the organic extracts dried over [NA2SO4.] Evaporation yielded the desired product as a yellow solid (16.2g, 73% yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57381-34-7.

Reference:
Patent; SCIOS INC.; WO2004/24159; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 57381-34-7, These common heterocyclic compound, 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 53 5-Chloro-2-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-ylmethoxy)-benzonitrile The title compound was produced in accordance with the general method of example 6 from (2-methyl-4-pyrrolidin-1-yl-quinolin-7-yl)-methanol (example 2) and 5-chloro-2-fluorobenzonitrile. Light yellow solid, ISP-MS: m/e=378.4 ([M+H]+).

The synthetic route of 57381-34-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Klug, Michael G.; Mattei, Patrizio; Mueller, Werner; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; Plancher, Jean-Marc; US2003/158179; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 57381-34-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred 00C solution of 1,1,1,3,3,3-Hexamethyldisilazane (63 mL, 0.3 mol) in dry diethyl ether was added dropwise n-Butyl lithium (2M in hexanes, 150 mL, 0.3 mol). A white suspension formed, to which was added 2-Fluoro-5-chlorobenzonitrile (21.0 g, 0.14 mol) over 5 min. The resultant orange mixture was allowed to warm to r.t. and stirred for 2h. The mixture was cooled to 00C and the reaction quenched by the addition of 3M HCl (aq.) (240 mL). The mixture was stirred for 0.5h before water (600 mL) was added. The purple organic layer was discarded and the aqueous layer basified to pH 14 with satd. NaOH (aq.). The aqueous layer was extracted with CHCI3 (5×100 mL) and the organic extracts dried over Na2SO4. Evaporation yielded the desired product as a yellow solid (16.2g, 73% yield).

The synthetic route of 5-Chloro-2-fluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2008/40778; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Chloro-2-fluorobenzonitrile

To a stirred [0C] solution of 1,1, 1,3, 3, [3-HEXAMETHYLDISILAZANE] (63 mL, 0.3 mmol) in dry diethyl ether was added dropwise n-Butyl lithium (2M in hexanes, 119 mL, 0.3 [MMOL).] A white suspension formed, to which was added [2-FLUORO-5-CHLOROBENZONITRILE (21.] 0 g, 0.14 mmol) over 5 min. The resultant orange mixture was allowed to warm to r. t. and stirred for 2h. The mixture was cooled to 0C and the reaction quenched by the addition [OF 3M HCI] (aq. ) (240 mL). The mixture was stirred for [0.] 5h before water (600 mL) was added. The purple organic layer was discarded and the aqueous layer basified to pH 14 with satd. NaOH (aq. ). The aqueous layer was extracted with [CHC13] [(5X100] mL) and the organic extracts dried over [NA2SO4.] Evaporation yielded the desired product as a yellow solid (16.2g, 73% yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57381-34-7.

Reference:
Patent; SCIOS INC.; WO2004/24159; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 57381-34-7, The chemical industry reduces the impact on the environment during synthesis 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

Preparation 10: 1-[5-Chloro-2-(4-methyl-piperazin-1-yl)-phenyl]-ethanone; STEP A; A mixture of 5-chloro-2-fluoro-benzonitrile (500 mg, 3.21 mmoi), K2CO3 (1.32 g, 9.64 mmol) and 1-methyi-piperazine (482 mg, 4.81 mmoi) in DMSO (6.4 ml) was stirred at 100C for 6 h and then partitioned between water and Et2O. The organic phase was dried over Na2SO4 and evaporated in vacuo. The crude mixture was purified by column chromatography (eluent: DCM/MeOH/NH4OH 98:2:0.1) to give 660 mg of 5-chloro-2-(4-methyl-piperazin-1-yl)-benzonitrile. Y= 87%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts