Fernandez, Maria-Carmen published the artcileDesign, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors, Application of 3-Formyl-5-(trifluoromethyl)benzonitrile, the main research area is tetrahydronaphthyridine preparation CETP inhibitor structure activity relationship.
This Letter describes the discovery and SAR optimization of 1,5-tetrahydronaphthyridines, a new class of potent CETP inhibitors. The effort led to the identification of I and II with in vitro human plasma CETP inhibitory activity in the nanomolar range (IC50 = 23 and 22 nM, resp.). Both I and II exhibited robust HDL-c increase in hCETP/hApoA1 dual heterozygous mice model.
Bioorganic & Medicinal Chemistry Letters published new progress about Cardiovascular disease. 569370-39-4 belongs to class nitriles-buliding-blocks, name is 3-Formyl-5-(trifluoromethyl)benzonitrile, and the molecular formula is C9H4F3NO, Application of 3-Formyl-5-(trifluoromethyl)benzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts