Category: 56043-01-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56043-01-7, name is 2-Amino-6-methylbenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 56043-01-7

General procedure: 1mmol 2-aminobenzonitrile (118mg), 1.2mmol bromobenzene, 6.7mg Pd(OAc)2 (3mol%), 21.5mg CataCXium A (6mol%), 1.5mmol DBU (225mul), 0.5mmol Mo(CO)6 (132mg), and 4mL DMF were given in an argon flushed pressure tube, which was subsequently sealed. The mixture was heated to 130C under stirring for 16h. After cooling to room temperature, the crude mixture was diluted in ethyl acetate and washed with water. The aqueous phase was extracted twice with ethyl acetate. The organic layers were combined, dried over Na2SO4, and the solvent was removed under reduced pressure. Column chromatography (hexane/ethyl acetate 8:2) gave 176mg (79%) N-(2-cyanophenyl)benzamide (a1)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wu, Xiao-Feng; Oschatz, Stefan; Sharif, Muhammad; Beller, Matthias; Langer, Peter; Tetrahedron; vol. 70; 1; (2014); p. 23 – 29;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56043-01-7 as follows. Safety of 2-Amino-6-methylbenzonitrile

Example 1: n-Propyl- (2-cyano-3-methyl-phenyl) sulfonamide 1.1 : 2-Cyano-3-methyl-phenylsulfonylchloride; A solution of 11.6 g (88 mmol) of 2-amino-6-methylbenzonitrile (prepared, e. g. accord- ing to WO 94/18980) in 120 ml of glacial acetic acid was initially charged and 32.2 g of concentrated hydrochloric acid were slowly added at room temperature. The reaction mixture was stirred at room temperatures for 10 minutes and then a solution of 6.4 g (92 mmol) of sodium nitrite in 20 ml of water was added dropwise at 5-10C. The reac- tion mixture was stirred at 0C for one hour to obtain the diazonium salt. In a separate stirred flask, a saturated solution of sulfur dioxide in glacial acetic acid was prepared at 10C and a solution of 5.5 g of copper ( . t) chloride in 11 ml of water was added. The reaction mixture of the diazonium salt which had been prepared beforehand was then added dropwise to the solution of the copper salt. The resulting mixture was stirred at room temperature for additional 45 minutes. Then the reaction mixture was poured into ice-cooled water and the aqueous phase was extracted three times with dichloro- methane. The combined organic layers were dried over a drying agent and filtered. The filtrate was concentrated in vacuo to afford 16.4 g (87% of the theory) of the title com- pound having a melting point of 75-77C.

According to the analysis of related databases, 56043-01-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF AKTIENGESELLSCHAFT; WO2005/35486; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 56043-01-7, A common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 9; Preparation of 1 ,8-bis(bromomethyl)-9/-/-fluoren-9-one; A. Preparation of 2-(imino(o-tolyl)methyl)-3-methylaniline; To a cooled (0 0C) solution of 2-amino-6-methylbenzonitrile (5.00 g, 37.81 mmol) in anhydrous tetrahydrofuran (50 mL) was added dropwise a solution of 2- methylphenylmagnesium bromide (77.5 ml_ of a 2 M solution in diethyl ether, 155.0 mmol). The resultant mixture was then heated at reflux for 16 h and allowed to cool to ambient temperature. The reaction mixture was then poured into ice-water (500 mL) and concentrated hydrochloric acid (100 mL) was added. The mixture was transferred to a separatory funnel and was washed with diethyl ether (3 chi 100 mL). The aqueous phase was rendered alkaline by the addition of solid sodium hydroxide (8.0 g) and was extracted with dichloromethane (3 x 150 mL). The combined dichloromethane extract was washed with brine (150 mL), dried over sodium sulfate and filtered. The filtrate was concentrated in vacuo to dryness to afford 2-(imino(o-tolyl)methyl)-3-methylaniline: MS (ES+) m/z 225.3 (M + 1 ).

The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2008/109840; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 56043-01-7, A common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-amino-6-methylbenzonitrile (132.2 mg, 1.0 mmol) was sequentially added to a 100 mL high pressure sealed tube, benzyl alcohol(129.6mg, 1.2mmol, 1.2equiv.), cesium hydroxide monohydrate (167.9mg, 1.0mmol), add an air ball at the sealing mouthAfter stirring at 120 C for 36 h, the product was completely purified by column chromatography by TLC or GC-MS. The isolated yield was 51%.

The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 56043-01-7, These common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 6-chloro-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide (Description 6) (100 mg), 2- amino-6-methyl-benzonitrile (43 mg), cesium carbonate (168mg), tris (dibenzylideneacetone) dipalladium (0) (ex-Aldrich, 3.36mg) and 4,5-bis (diphenylphosphino) – 9,9-dimethylxanthene (ex-Aldrich, 2.3 mg) and 1,4-dioxan (1 ml) was heated to relux under nitrogen for 24h. When cool, the mixture was diluted with ethyl acetate and filtered through a PTFE disc (1.0 M) disc and the filtrate evaporated. The residue was purified using the Biotage Horizon HPFC System and the resultant product was triturated with ether, washed with ether, and dried in vacuo at 40 to give 6- (2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl- nicotinamide (15mg). NMR (d6-DMSO) 8 1.16 (6H, d), 2.46 (3H, s), 3.35-3. 45 (1H, m), 4. 36-4. 47 (2H, m), 6.95 (1H, s), 7.08 (1H, d), 7.13 (1H, t), 7. 35 (2H, m), 7. 39 (2H, t), 7.68 (1H, d), 8.07 (1H, s), 8.9 (1H, m), 9.14 (1H, s). LC/MS t = 3. 27min, [MH+] 403 consistent with molecular formula C24H23FN40

The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; DOUGHTY, Jennifer, Margaret; WO2005/74939; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Amino-6-methylbenzonitrile

General procedure: Adapted from a literature procedure,1 the appropriate organonitrile (1.0 eq.) and K2CO3(0.2eq.)wereaddedtoamicrowavetubewithastir-barwithdeionizedwater(8.5mLpermmolsubstrate).Afterirradiationundermicrowaveat150Cfor30minutes,thereactionmixturewascooled,extractedwithEtOAc(320mL),thecombinedphasesdriedoverMgSO4andexcesssolventremovedinvacuo.TheresiduewaspurifiedbyFCC,ifrequired,togivethetitlecompound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56043-01-7, its application will become more common.

Reference:
Article; Sutherell, Charlotte L.; Ley, Steven V.; Synthesis; vol. 49; 1; (2017); p. 135 – 144;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

56043-01-7, The chemical industry reduces the impact on the environment during synthesis 56043-01-7, name is 2-Amino-6-methylbenzonitrile, I believe this compound will play a more active role in future production and life.

A solution of 2-amino-6-methylbenzonitrile (1.32 g, 10 mmol) and sulfamide (4.81 g, 50 mmol) in dry 1,4-dioxane (50 mL) was refluxed under nitrogen for 3 days. After the reaction mixture was cooled down to room temperature, the precipitate was filtered and washed with dioxane. The filtrate was concentrated under reduced pressure, and the residue was purified by chromatography on silica gel eluding with EtOAc/hexanes (3:7) to give the title compound as a pale-white solid. 1H NMR (400 MHz, DMSO-d6) delta 2.44 (s, 3H), 7.19-7.21 (m, 3H), 7.39-7.41 (d, J=8.4 Hz, 1H), 7.53 (t, J=8.0 Hz, 1H), 9.41 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 2-Amino-6-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SENOMYX, INC.; US2008/306053; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts