14-Sep-2021 News Extended knowledge of 5332-06-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromobutanenitrile, other downstream synthetic routes, hurry up and to see.

Reference of 5332-06-9, The chemical industry reduces the impact on the environment during synthesis 5332-06-9, name is 4-Bromobutanenitrile, I believe this compound will play a more active role in future production and life.

Reference Example 1 4-(p-tolylamino)butanenitrile p-Toluidine (10.407 g, 97.116 mmol) was dissolved in anhydrous acetonitrile and, after adding potassium carbonate (49.9 g, 361.272 mmol), stirred at room temperature for 10 minutes. After slowly adding 4-bromobutyronitrile (10.1 mL, 101.972 mmol) to the resultant reaction mixture, reaction was carried out at 100 C. for 2 days. The mixture was cooled to room temperature and the produced solid was removed by filtering. The filtrate was concentrated under reduced pressure. A target compound (13.23 g, 78.2%) was yielded. A target compound was used in the next step without further purification. 1H NMR (CDCl3, 300 MHz) delta 7.04 (d, J=8.0 Hz, 2H), 6.57 (d, J=8.3 Hz, 2H), 3.62 (s, 1H, NH), 3.29 (q, J=6.3 Hz, 2H), 2.47 (t, J=7.0 Hz, 2H), 2.28 (s, 3H), 1.96 (t, J=6.8 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromobutanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Korea Institute of Science and Technology; US2011/319619; (2011); A1;,
Nitrile – Wikipedia,
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Some scientific research about 5332-06-9

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

Application of 5332-06-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5332-06-9 as follows.

General procedure: To a stirred solution of N-norhydromorphone (S10 in the SupplementaryMaterials, 0.406 g, 1.5 mmol) in DMF (10 mL) were added NaHCO3 (0.504 g, 6 mmol) and 1-(2-bromoethyl)-4-chlorobenzene (0.480 mL, 3.3 mmol). The mixture was heated at 90 C overnight,cooled to room temperature, filtered through Celite, and concentrated in vacuo. Water (10 mL) wasadded and the mixture extracted with CHCl3 (3 × 20 mL). The combined organics were washed withH2O (5 × 20 mL), dried over Na2SO4, filtered through Celite, and concentrated in vacuo to afford 2ifree base as a crude colorless oil. Purification of this oil by SiO2 column chromatography with 10%NH4OH in MeOH/CHCl3 (gradient, 0 ? 4% of 10% NH4OH) afforded 2i (0.420 g, 70%) as a colorlessoil.

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Adler, Martin W.; Bergman, Jack; Chadderdon, Aaron M.; Crowley, Rachel Saylor; Geller, Ellen B.; Hanna, Ramsey D.; Hassan, Sergio A.; Herdman, Christine A.; Inan, Saadet; Irvin, Thomas C.; Jacobson, Arthur E.; Kaska, Sophia; Katz, Jonathan L.; Kopajtic, Theresa A.; Lee, Yong-Sok; Paronis, Carol A.; Prisinzano, Thomas E.; Rice, Kenner C.; Traynor, John R.; Wang, Meining; Withey, Sarah L.; Molecules; vol. 25; 11; (2020);,
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Continuously updated synthesis method about 5332-06-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromobutanenitrile, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 5332-06-9, name is 4-Bromobutanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-06-9, Quality Control of 4-Bromobutanenitrile

To a solution of 4-bromobutanenitrile (1.50 g, 10.17 mmol) in dimethylformamide (20 ml) were added 1-(4-chlorophenyl)piperazine (2.0 g, 10.17 mmol)and potassium carbonate (2.81 g, 20.34 mmol) at room temperature and the reaction mixture was stirred for 3 h at same temperature. The progress of the reaction was monitored by TLC. The reaction mixture was diluted with water (50 ml) and the aqueous layer was extracted with ethyl acetate (3 x 50 ml). Thecombined organic layer was dried over anhydrous sodium sulphate. The solvent in the organic layer was removed under reduced pressure to obtain a crude product, which was purified by column chromatography over silica gel (100-200 mesh) using 10% ethyl acetate in hexane to yield the title compound (2.32 g, 86% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromobutanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; JANA, Gourhari; KURHADE, Sanjay, Pralhad; JAGDALE, Arun, Rangnath; KUKREJA, Gagan; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2014/9872; (2014); A1;,
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Research on new synthetic routes about 4-Bromobutanenitrile

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5332-06-9, name is 4-Bromobutanenitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Bromobutanenitrile

(R)-4-((2-(1′-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4]pyrimidine-5,4′-piperidin]-3(2H.4H,7H)-yl)-1-phenylethyl)amino)butanenitrile (1 -16) (10 g, 15 mmol) was dissolved in acetonitrile (200 mL), and then Nal (6.2 g, 45 mmol), K2C03 (6.8 g, 45 mmol) and 4-bromobutanenitrile (2.3 mL, 22.5 mmol) were added to the mixture in sequence, followed by stirring for 12 hrs at 95 C. The resulting solution was cooled down to room temperature, filtered, and concentrated under reduced pressure to remove acetonitrile therefrom. The resulting solution was diluted with dichloromethane, washed with a saturated aqueous ammonium chloride solution, and the organic layer was separated. The organic layer was concentrated under reduced pressure and the resulting residue was purified by silica gel chromatography (eluent: dichloromethane/methanol = 98/2-95/5) and dried under vacuum to obtain the title compound as white foam (8.2 g, yield: 75%).

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SK CHEMICALS CO., LTD.; KIM, Seon-Mi; KIM, Jae-Sun; LEE, Minhee; LEE, So-Young; LEE, Bong-Yong; SHIN, Young Ah; PARK, Euisun; LEE, Jung A; HAN, Min-Young; AHN, Jaeseung; YOO, Taekyung; KIM, Hun-Taek; WO2013/129879; (2013); A1;,
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Extended knowledge of 4-Bromobutanenitrile

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

5332-06-9, name is 4-Bromobutanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 5332-06-9

Example 10; 4-Azidobutanenitrile (22).; Sodium azide (1.2 g, 18.5 mmol) was added to a solution of 4-bromobutyronitrile (20, 1.8 g, 12.0 mmol) in DMSO (20 mL). After 18 h of stirring at room temperature, water (40 mL) was added, and the solution was extracted with diethyl ether. Evaporation of the solvent gave 22 as a light yellow oil EPO (0.9 g, 67%). IH NMR (400 MHz, CDCl3) £3.5 (t, 2H, J= 6.0 Hz), 2.5 (t, 2H, J= 7.2 Hz), 1.90 – 1.95 (m, 2H).

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTHWESTERN UNIVERSITY; WO2007/35964; (2007); A2;,
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Extracurricular laboratory: Synthetic route of 5332-06-9

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 5332-06-9, A common heterocyclic compound, 5332-06-9, name is 4-Bromobutanenitrile, molecular formula is C4H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 34-(benzylamino)butanenitrileBenzylamine (5.02 mL, 46 mmol) and calcium carbonate (23.65 g, 171.12 mmol) dissolved in anhydrous acetonitrile (115 mL) were stirred for 10 minutes at room temperature. After adding 4-bromonitrile (4.78 mL, 48.3 mmol), reaction was carried out at 100 C. for 2 days. A target compound (6.69 g, 38.395 mmol, 83.5%) was yielded as liquid by separating the reaction mixture in the same manner as Reference Example 1.1H NMR (CDCl3, 300 MHz) delta 7.37-7.29 (m, 5H), 3.79 (s, 2H), 2.77 (t, J=6.6 Hz, 2H), 2.48 (t, J=7.1 Hz, 2H), 1.88-1.79 (m, 2H).

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Korea Institute of Science and Technology; US2011/319619; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Research on new synthetic routes about C4H6BrN

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5332-06-9 as follows. Product Details of 5332-06-9

To a stirred suspension of NaH (0.092g, 60% dispersion in mineral oil, 1.2 mmol) in THF (15 mL) at 0 C was added dropwise a solution of 4 (0.5 g, 1 mmol) in THF (15 mL). The mixture wasstirred 0 C for 10 min and then a solution of 4-bromobutyronitrile (0.34 g,0.228 mL, 1.2 mmol) in THF (5 mL) was added slowly. The mixture was allowed towarm to r.t. and stirred overnight. It was then cooled to 0 C and cold water(5 mL) was added very slowly and extracted with ethyl acetate (2 x 15 mL). Thecombined organic phase was washed with water (3 x 10 mL), brine (10 mL), driedover Na2SO4 and evaporated. The product 5 (0.56 g,92%) was obtained by column chromatography on silica gel using pet ether: ethylacetate as an eluents.

According to the analysis of related databases, 5332-06-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pakhare, Deepali S.; Kusurkar, Radhika S.; Tetrahedron Letters; vol. 56; 44; (2015); p. 6012 – 6015;,
Nitrile – Wikipedia,
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The origin of a common compound about 5332-06-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-06-9, name is 4-Bromobutanenitrile, A new synthetic method of this compound is introduced below., SDS of cas: 5332-06-9

(R)-3-(2-amino-2-phenylethyl)-1′-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4′-piperidine]-2,4(3H,7H)-dione (1-16) (10 g, 15 mmol) was dissolved in acetonitrile (200 mL), and then NaI (6.2 g, 45 mmol), K2CO3 (6.8 g, 45 mmol) and 4-bromobutanenitrile (2.3 mL, 22.5 mmol) were added to the mixture in sequence, followed by stirring for 12 hrs at 95 C. The resulting solution was cooled down to room temperature, filtered, and concentrated under reduced pressure to remove acetonitrile therefrom. The resulting solution was diluted with dichloromethane, washed with a saturated aqueous ammonium chloride solution, and the organic layer was separated. The organic layer was concentrated under reduced pressure and the resulting residue was purified by silica gel chromatography (eluent: dichloromethane/methanol=98/2?95/5) and dried under vacuum to obtain the title compound as white foam (8.2 g, yield: 75%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SK CHEMICALS CO., LTD.; Kim, Seon-Mi; Kim, Jae-Sun; Lee, Minhee; Lee, So-young; Lee, Bong-Yong; Shin, Young Ah; Park, Euisun; Lee, Jung A; Han, Min-Young; Ahn, Jaeseung; Yoo, Taekyung; Kim, Hun-Taek; US2015/166558; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Research on new synthetic routes about C4H6BrN

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

Related Products of 5332-06-9, These common heterocyclic compound, 5332-06-9, name is 4-Bromobutanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(trans) 1-(1 H-benzimidazol-2-ylmethyl)-2,3,3a,4,5,9b-hexahydro-1 H-pyrrolo[3,2- /?]quinoline (0.032 g, 0.11 mmol), potassium carbonate (0.075 g, 0.55 mmol), 4- bromobutanenitrile (0.024 g, 0.16 mmol), and potassium iodide (5 mg) in 3 ml_ of N,N-dimethyIformamide were heated to 80 2C in a sealed tube for 16 hours. The mixture was allowed to cool to room temperature and quenched with 5 ml_ of water. The mixture was extracted 3 times with 5 mL of dichloromethane and the combined organic layers concentrated. The residue was dissolved in 20 mL of a 2M ammonia solution in methanol and hydrogenated under 40 psi of hydrogen for 18 hours, with 30 mg of raney nickel as catalyst. The catalyst was filtered off over celite and the filtrate concentrated. The residue was purified by silica chromatography eluting with a 0% to 10% gradient of aqueous ammonia in acetonitrile to yield 29 mg (70%) of (trans) 4-[2-(2,3,3a,4,5,9b-hexahydro-1 H-pyrrolo[3,2-/7]quinolin-1 -ylmethyl)-1 H- benzimidazol-1-yl]-1 -butanamine. 1 H NMR (400 MHz, METHANOL-D4) delta ppm 1.1 (m, 2 H), 1.4 (m, 2 H), 1.7 (m, 2 H), 1.8 (m, 1 H), 2.1 (m, 1 H), 2.4 (m, 1 H), 2.5 (t, J=7.4 Hz, 2 H), 2.7 (m, 1 H), 2.8 (m, 2 H), 2.9 (m, 1 H), 3.6 (d, J=8.6 Hz, 1 H), 3.6 (d, J=13.6 Hz, 1 H), 3.7 (m, 1 H), 3.8 (m, 1 H), 4.7 (d, J=13.6 Hz, 1 H), 7.2 (m, 2 H), 7.4 (m, 2 H), 7.6 (m, 1 H), 7.7 (d, J=7.9 Hz, 1 H), 8.4 (d, J=6.4 Hz, 1 H); MS m/z376(M+1).

The synthetic route of 5332-06-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/96444; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 5332-06-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-06-9, name is 4-Bromobutanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 5332-06-9

Preparation of 4-iodobutanenitrile After 4-bromobutanenitrile (1.48 g, 10 mmol) was dissolved in acetonitrile (30 mL), sodium iodide (6 g, 40 mmol) was added thereto, and the mixture was stirred for 70 minutes at 60 C. After the temperature was lowered to room temperature, water (30 mL) was added to the reaction material, and the result was extracted with ethyl acetate (30 mL*2). Excess iodine was removed by washing the organic layer with a 1% aqueous sodium thiosulfate solution, and the organic layer was washed with salted water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to give a target compound (1.86 g, 95%). 1H-NMR (300 MHz, CDCl3) delta 2.13 (m, 2H), 2.53 (t, J=13.8 Hz, 2H), 3.30 (t, J=13 Hz, 2H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; SON, Jong Chan; KIM, Bong Jin; KIM, Jae Hak; LEE, Ill Young; YUN, Chang Soo; LEE, Sang Ho; LEE, Chong Kgo; US2014/249162; (2014); A1;,
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Nitriles – Chemistry LibreTexts