Category: 53312-79-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Amino-4-chlorobenzonitrile

To a stiired solution of compound IM (1.0 g. 6.57 mmoi) in DMF (20 mL) under argon aimospliere was added potassium ethyl xanthate (2.6 g, 16.44 rnmol) at RT. The reaction mixture was heated to 110 C for 12 h. The progress of the reaction was monitored by TLC. The reaction mixture was acidified with IN HC1 solution (50 mL) to pH~2 to get the solid. The solid was filtered, washed wife -hexane (2 x 20 mL) and dried under reduced pressure to obtain compoimd IN (1.0 g, 5.20 rnmol, 80%) as a brown solid. NMR (400 MHz, CDC3): delta 10.03 (brs, 1H); 7.55 (s, 2H), 7.48 (s, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53312-79-1.

Reference:
Patent; VIAMET PHARMACEUTICALS, INC.; YATES, Christopher, M.; SHAVER, Sammy, R.; HOEKSTRA, William, J.; (455 pag.)WO2017/117393; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 53312-79-1, These common heterocyclic compound, 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 4-Chloro-3-(1-nitro-2-naphthylamino)benzonitrile A suspension of 1-nitro-2-naphthyltriflate (1.50 g, 4.67 mmol), 3-amino-4-chlorobenzonitrile (1.05 g, 6.87 mmol), potassium carbonate (645 mg, 4.67 mmol), tetrakis(triphenylphosphine)palladium(0) (162 mg, 0.14 mmol) and triphenylphosphine (65 mg, 0.47 mmol) in toluene (45 mL) was stirred at 110C for 16 hours. The reaction mixture was cooled to room temperature, and filtered. The filtrate was diluted with chloroform, washed with 0.2M hydrochloric acid, a saturated aqueous sodium bicarbonate solution and saturated brine. The organic layer was dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate = 1/1), to give the titled compound (900 mg, yield 60%). 1H-NMR(CDCl3, 400MHz) delta: 7.31(1H, dd, J=2, 8Hz), 7.44(1H, d, J=9Hz), 7.52(1H, t, J=8Hz), 7.58(1H d, J=8Hz), 7.62(1H, d, J=1Hz), 7.68(1H, m), 7.84(1H, d, J=8Hz), 7.96(1H, d, J=9Hz), 8.25(1H, d, J=9Hz), 8.67(1H, br s).

Statistics shows that 3-Amino-4-chlorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 53312-79-1.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; EP2397480; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Amino-4-chlorobenzonitrile

To a stiired solution of compound IM (1.0 g. 6.57 mmoi) in DMF (20 mL) under argon aimospliere was added potassium ethyl xanthate (2.6 g, 16.44 rnmol) at RT. The reaction mixture was heated to 110 C for 12 h. The progress of the reaction was monitored by TLC. The reaction mixture was acidified with IN HC1 solution (50 mL) to pH~2 to get the solid. The solid was filtered, washed wife -hexane (2 x 20 mL) and dried under reduced pressure to obtain compoimd IN (1.0 g, 5.20 rnmol, 80%) as a brown solid. NMR (400 MHz, CDC3): delta 10.03 (brs, 1H); 7.55 (s, 2H), 7.48 (s, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53312-79-1.

Reference:
Patent; VIAMET PHARMACEUTICALS, INC.; YATES, Christopher, M.; SHAVER, Sammy, R.; HOEKSTRA, William, J.; (455 pag.)WO2017/117393; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 53312-79-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, a water separator was installed in a 2L four-necked flask, and 152.6 g of 2-chloro-5-cyanoaniline, 130 g of benzaldehyde, 12 g of p-toluenesulfonic acid and 1.2 L of xylene were added, and the mixture was refluxed for 6 hours.The reaction can be stopped without significant water droplets in the water separator.After cooling to room temperature, it was washed with 100 mL of 10% aqueous sodium hydroxide solution, and the organic phase was decomposed under reduced pressure.The obtained residue was distilled under reduced pressure to give 215 g of the desired product N-benzylidene-2-chloro-5-cyanoaniline. The gas chromatographic content was 98.4%, and the yield was 89.3%.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-4-chlorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Zeng Yuan; Zhou Yan; Li Bolan; Chen Xiaobin; Wang Daoxiang; Yang Jianhua; (19 pag.)CN108276294; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 53312-79-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

j00316j A mixture of 3-amino-4-chlorobenzonitrile (1.0 g, 6.6 mmol) and potassium 0-ethyl carbonodithioate (2.1 g, 13.1 mmol) in 1-methylpyrrolidin-2-one (5 mL) at 25 C was degassed and purged with nitrogen 3 times. The mixture was stirred at 120 C for 10 hours, then poured into ice water (200 mL) and acidified with 1 mL concentrated hydrochloric acid, resulting in formation of a solid. The solid was collected by filtration, washed with water (3 x 10 mL) and dried in vacuo to give compound B-22 (1.1 g, crude) as a yellow solid, which was used directly without further purification. LCMS (B): tR=0.613 mi, (ES) mz (M+H) = 193.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-4-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53312-79-1 as follows. Computed Properties of C7H5ClN2

A solution of 3-amino-4-chlorobenzonitrile (562mg, 3.69mmol) and sodium phenyl sulfide (731mg, 5.53mmol) of a DMF solution (3.7 ml) was stirred using a microwave reaction apparatus at 150 C 50 min. The reaction mixture was added a saturated aqueous ammonium chloride solution, extracted with ethyl acetate, and the organic layer was washed with saturated brine and water, dried over anhydrous magnesium sulfate. After the drying agent was filtered off and concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (ethyl acetate / hexane) to give (637mg, 76%) of the title compound as a colorless solid

According to the analysis of related databases, 53312-79-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; MURATA, TAKESHI; HARA, SOUSUKE; NIIZUMA, SATOSHI; HADA, KIHITO; KAWADA, HATSUO; SAKAITANI, MASAHIRO; SHIMADA, HIDEAKI; NAKANISHI, YOSHITO; (453 pag.)TW2016/5805; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 53312-79-1, The chemical industry reduces the impact on the environment during synthesis 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, I believe this compound will play a more active role in future production and life.

General procedure: Sodium ethanethiolate (362 mg, 4.3 mmol) was added to a solution of 5-bromo-2-fluorobenzaldehyde (546 mg, 2.7 mmol) in DMF (1.08 ml), and the mixture was stirred at 60C. After one hour, sodium ethanethiolate (123 mg, 1.5 mmol) was added thereto. After 15 minutes, the reaction solution was returned to room temperature, and a 1 N aqueous hydrochloric acid solution was added thereto, and extraction was performed with ethyl acetate. The organic layer was sequentially washed with a saturated aqueous sodium bicarbonate solution and brine, and dried over anhydrous sodium sulfate. The drying agent was removed by filtration, and the residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (163 mg, 24%) as a yellow oil. The title compound was synthesized from 3-amino-4-chloro-benzonitrile under the same conditions as for Compound 4. However, the reaction was performed by heating at 80C with microwave irradiation.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-4-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; MURATA, Takeshi; KAWADA, Hatsuo; NIIZUMA, Satoshi; HARA, Sousuke; HADA, Kihito; SHIMADA, Hideaki; TANAKA, Hiroshi; MIO, Toshiyuki; EP2842946; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., name: 3-Amino-4-chlorobenzonitrile

Step A:2-Th ioxo-2 , 3-d ihyd robenzoth iazole-5-carbon itrile; A mixture of 3-amino-4-chlorobenzonitrile (200 mg, 1.32 mmol) and potassium o-ethyl- xanthate (422 mg, 2.64 mmol) in lambda/-methyl-2-pyrrolidone (1.5 ml.) was heated at 140 0C for 2 h. After cooling, the mixture was poured into ice-water. Then concentrated hydrochloric acid(0.2 ml.) was added. The solid was collected, washed with water and dried to give 2-thioxo-2,3-dihydrobenzothiazole-5-carbonitrile 250 mg (99 %).1H NMR (400 MHz, CDCI3): delta 7.53-7.50 (m, 2 H); 7.49 (s, 1 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts