52688-08-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52688-08-1, name is Octan-2-yl 2-cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 1.40 moles of butyl cyanoacetate and 2.1 moles of methylene diacetate, obtained through the preparative example 1, were added to a 1 L reactor. Subsequently, the mixture was heated to a temperature comprised between 120 and 130 C. Then 5 mol% of piperazine and 15 mol% of p-toluenesulfonic acid monohydrate were added. The reaction was monitored by gas chromatography or nuclear magnetic resonance every 30 min. After 1 hour, the reaction was terminated, and the n-butyl cyanoacrylate was obtained with a selectivity of 94%, where the selectivity is understood as the amount of monomer produced with respect to the cyanoacetate that has reacted. Subsequently, acetic acid was removed under vacuum and stabilizers were added to the residue for the distillation of the monomer.
The synthetic route of Octan-2-yl 2-cyanoacetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Afinitica Technologies, S. L.; Tchaplinski, Vladimir; Gherardi, Stefano; de la Fuente Molina, Veronica; EP2927209; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts