Category: 5216-17-1

These common heterocyclic compound, 5216-17-1, name is 2,3,5,6-Tetrafluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2,3,5,6-Tetrafluorobenzonitrile

[0154] NaH (60% in mineral oil, 128 mg, 3.2 mmol) was slowly added to a solution of 2,3-dihydroimidazo[1,2-cjquinazolin-9-ol (300 mg, 1.6 mmol) in THF (10 mL) at 0 C. The reaction mixture was degassed with N2 and stirred at 0 C for 30 mm. Then 2,3,5,6- tetrafluorobenzonitrile (308 mg, 1.8 mmol) was added and the mixture was stirred at room temperature for 18 hours. The reaction mixture was quenched by MeOH (5 mL) at 0 C. The resulting mixture was evaporated and the residue was purified on silica gel column flash chromatography (DCM/MeOH from 60:1 to 10:1, v/v) to afford 2-((2,3-dihydroimidazo[1,2- cjquinazolin-9-yl)oxy)-3,5,6-trifluorobenzonitrile (200 mg, 36% yield) as a yellow solid.

The synthetic route of 2,3,5,6-Tetrafluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABM THERAPEUTICS, INC.; CHEN, Chen; (154 pag.)WO2019/60611; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 5216-17-1,Some common heterocyclic compound, 5216-17-1, name is 2,3,5,6-Tetrafluorobenzonitrile, molecular formula is C7HF4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: CZ-CZO (3.90 g, 4.08 mmol) and sodium hydride (0.6 g, 24.3 mmol) were added to dry tetrahydrofuran (THF, 20 mL), and the mixture was stirred at room temperature for 0.5 h.Further, 2,3,5,6-tetrafluorobenzonitrile (0.089 g, 0.51 mmol) was added, and the reaction was stirred at room temperature for 12 h. After completion of the reaction, the mixture was quenched with water and extracted with dichloromethane. Purification by column chromatography gave the final product C5, yield 75%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3,5,6-Tetrafluorobenzonitrile, its application will become more common.

Reference:
Patent; Southeast University; Jiang Wei; Huang Suli; Sun Yueming; (21 pag.)CN108586318; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts