Synthesis of some 3,5-disubstituted 1,2,4-oxadiazoles starting from aryl nitriles was written by Naveena, C. S.;Lobo, Prajwal Lourdes;Poojary, Boja;Kumari, Nalilu Sucheta. And the article was included in Organic Chemistry: An Indian Journal in 2008.Synthetic Route of C11H13NO This article mentions the following:
The synthesis of some 3,5-disubstituted 1,2,4-oxadiazoles starting from arylnitriles is described. Arylnitriles are converted to arylamidoximes and then condensed with aromatic acid chlorides to form 1,2,4-oxadiazoles. Structures of the products were characterized by anal. data and spectral studies. All compounds of the series were screened for their anti-bacterial and anti-fungal activity. Most of the tested compounds showed moderate antifungal and antibacterial activity comparable with that of the standard drug. In the experiment, the researchers used many compounds, for example, 4-iso-Butoxybenzonitrile (cas: 5203-15-6Synthetic Route of C11H13NO).
4-iso-Butoxybenzonitrile (cas: 5203-15-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Synthetic Route of C11H13NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts