In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 519059-09-7, name is 5-(Cyanomethyl)-2-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H5FN2
Step 1: 5-[(6-Chloro-5-isopropylpyridazin-3-yl)(cyano)methyl]-2-fluorobenzonitrile (G1) To an ice-cold solution of 5-(cyanomethyl)-2-fluorobenzonitrile (1 eq) and 3,6-dichloro-4-isopropylpyridazine (1.3 eq) (Reference: Org. Prep.+Proc. Int. 1988, 20, 117 and U.S. Pat. No. 4,628,088, 1986) in THF (38 mL, 0.1 M) was added portionwise NaH (1 eq). The reaction was stirred at 0 C. for 15 min and then warmed to RT and stirred for 2 hrs. The reaction was quenched with a sat. aq. NaHCO3 and extracted with EtOAc. The combined organic fractions were washed with brine, dried (Na2SO4) and concentrated under reduced pressure. The crude was purified by silica gel chromatography, eluding with petroleum ether:EtOAc (8:2) to afford the title compound. 1H NMR (400 MHz, CDCl3) delta: 7.80-7.79 (2H, m), 7.49 (1H, s), 7.31-7.29 (1H, m), 5.63 (1H, s), 3.34-3.28 (1H, m), 1.36-1.29 (6H, m). MS (ES) C16H12ClFN4 required: 314/316, found: 315/317 (M+H)+.
The synthetic route of 519059-09-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jones, Philip; Kinzel, Olaf; Pescatore, Giovanna; Llauger Bufi, Laura; Schultz-Fademrecht, Carsten; Ferrigno, Federica; US2009/176765; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts