Category: 5098-14-6

On October 1, 2007, Carreiras, M. Carmo; Eleuterio, Ana; Dias, Catarina; Brito, M. Alexandra; Brites, Dora; Marco-Contelles, J.; Gomez-Sanchez, Elena published an article.Electric Literature of 5098-14-6 The title of the article was Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles. And the article contained the following:

The synthesis of a series of 2-substituted 5-amino-4-cyano-1,3-oxazoles and the Friedlander-type reaction of some of them with cyclic ketones was described. Oxazolo[5,4-b]quinoline derivatives were tacrine analogs provided by the Friedlander reaction. Their anticholinesterase activity has been investigated and the compound I was found to be the most active (60% inhibition), at the maximum soluble concentration The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to aryl acid chloride chloride aminomalonitrile tosylate heterocyclization, alkyl acid chloride aminomalonitrile tosylate heterocyclization, amino cyanooxazole derivative preparation cycloalkanone friedlander cyclization aluminum chloride and other aspects.Electric Literature of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 1991, Cristalli, Gloria; Eleuteri, Alessandra; Franchetti, Palmarisa; Grifantini, Mario; Vittori, Sauro; Lupidi, Giulio published an article.Category: nitriles-buliding-blocks The title of the article was Adenosine deaminase inhibitors: synthesis and structure activity relationships of imidazole analogs of erythro-9-(2-hydroxy-3-nonyl)adenine. And the article contained the following:

A series of erythro-1-(2-hydroxy-3-nonyl)imidazole derivatives were synthesized and evaluated for adenosine deaminase (ADA) inhibitory activity, in order to introduce simplifications in the ADA inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine [EHNA, (I; X = N)] and 3-deaza-I (X = CH). Opening the pyrimidine or pyridine ring of I (X = N, CH), resp. led to compounds which are still ADA inhibitors. The most potent compound was erythro-1-(2-hydroxy-3-nonyl)imidazole-4-carboxamide (II; Ki = 3.53 × 10-8 M), which provided potential donor and acceptor sites for hydrogen bonding. Lack of one of this sites could account for the order of potency of all compounds examined in this series. Opening the same ring in adenosine and in 3-deazaadenosine led to fully inactive compounds These results support the hypothesis of the existence, at or near the enzyme active site, of a hydrophobic region able to bind the erythro-nonyl moiety. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to adenosine deaminase inhibitor, erythrohydroxynonyladenine analog, structure activity relationship erythrohydroxynonylimidazole, adenine erythrohydroxylnonyl analog, imidazole erythrohydroxynonyl structure activity relationship and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2020, Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; Bolea, Irene; Jimeno, M. Luisa; Mateus, M. Luisa; Oliveira-Campos, Ana M. F.; Unzeta, Mercedes; Marco-Contelles, Jose; Majekova, Magdalena; Ramsay, Rona R.; Carreiras, M. Carmo published an article.Formula: C10H11N3O3S The title of the article was Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents. And the article contained the following:

Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and Aβ anti-aggregating properties. Eighty-three nitrile-containing compounds, 13 of which are new, were synthesized and evaluated. In vitro screening revealed that 31, a new compound, presented the best lead for trifunctional inhibition against MAO A (0.34μM), MAO B (0.26μM), and AChE (52μM), while 32 exhibited a lead for selective MAO A (0.12μM) inhibition coupled to AChE (48μM) inhibition. Computational anal. revealed that the malononitrile group can find an advantageous position with the aromatic cleft and FAD of MAO A or MAO B. However, the total binding energy can be handicapped by an internal penalty caused by twisting of the ligand mol. and subsequent disruption of the conjugation (32 in MAO B compared to the conjugated 31). Conjugation is also important for AChE as well as the hydrophilic character of malononitrile that allows this group to be in close contact with the aqueous environment as seen for 83. Although the effect of 31 and 32 against Aβ1-42, was very weak, the effect of 63 and 65, and of the new compound 75, indicated that these compounds were able to disaggregate Aβ1-42 fibrils. The most effective was 63, a (phenylhydrazinylidene)propanedinitrile derivative that also inhibited MAO A (1.65μM), making it a potential lead for Alzheimer’s disease application. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to nitrile compound acetylcholinesterase monoamine oxidase alzheimer agent biol evaluation, ache inhibitors, alzheimer’s disease, aβ1-42 disaggregating agents, mao inhibitors, in silico study, nitrile-containing compounds and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bartlett, Robert T.; Cook, Alan F.; Holman, Michael J.; McComas, Warren W.; Nowoswait, Eugene F.; Poonian, Mohindar S.; Baird-Lambert, Judy A.; Baldo, Brian A.; Marwood, John F. published an article in 1981, the title of the article was Synthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine.Product Details of 5098-14-6 And the article contains the following content:

Analogs of 1-methylisoguanosine (I, R = Me, R1 = H, R2 = OH) were evaluated as muscle relaxants, antiinflammatory agents, allergy inhibitors, and for cardiovascular activity. Cyclizing imidazole nucleoside II with RNCO (R = Et, Bu, octyl, Ph) and deprotecting gave I (R = Et, Bu, octyl, Ph; R1 = H, R2 = OH). Bromination of I (R = Me, R1 = H, R2 = OH) with Br2-H2O gave I (R = Me, R1 = Br, R2 = OH) which reacted with N2H4 to give I (R = Me, R1 = NHNH2, R2 = OH). This was cleaved with Raney Ni to give I (R = Me, R1 = NH2, R2 = OH). Deamination of 1-methylguanosine with NaNO2 in aqueous AcOH gave 1-methylxanthosine. Iodination of I (R = Me, R1 = H, R2 = OH) with Me(PhO)3P+I- gave I (R = Me, R1 = H, R2 = iodo) which was cyclized to III or deiodinated to I (R = Me, R1 = R2 = H). The phosphate ester I (R = Me, R1 = H, R2 = OPO32-) was prepared as well as cyclic phosphate IV. C-Nucleoside V was prepared from Me β-D-ribofuranosyl-1-carboximidate. Cyclizing the 9-(2-hydroxyethoxy)methyl analog of II with MeNCO gave acyclic analog VI. Similarly prepared was the β-D-arabinofuranosyl analog of I (R = Me, R1 = H, R2 = OH). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to isoguanosine analog pharmaceutical preparation, antiinflammatory isoguanosine analog preparation, heart rate isoguanosine analog preparation, allergy isoguanosine analog preparation, muscle relaxant isoguanosine analog preparation, antihypertensive isoguanosine analog preparation, hypothermia isoguanosine analog preparation, nucleoside pharmaceutical preparation and other aspects.Product Details of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 11, 1991, Evans, Richard A.; Lorencak, Primoz; Ha, Tae Kyu; Wentrup, Curt published an article.SDS of cas: 5098-14-6 The title of the article was HCN dimers: iminoacetonitrile and N-cyanomethanimine. And the article contained the following:

Iminoacetonitrile H(NC)C:NH (I) has been prepared by two methods: (i) thermal decomposition of the tosylhydrazone salts H2N(NC)C:NN-TosM+ (Tos = tosyl, M = Na, Li) at 200° and (ii) Ar matrix photolysis of azidoacetonitrile. Ab initio calculations indicate that Z-I is of slightly lower energy than E-I, and this is confirmed by the IR spectra with use of the thermal methods. E-I/Z-I undergo photochem. interconversion, giving a ca. 3:1 photostationary E:Z ratio. E-I and Z-I are fully characterized by their gas-phase, matrix, and thin-film IR spectra, which are in excellent agreement with ab initio calculations, by 1H and 13C NMR spectroscopy in solution, and by mass spectrometry. I polymerizes in solution above -40°; pyrolysis produces HCN, and matrix photolysis produces HNC and van der Waals complexes containing HNC. N-tert-Butyliminoacetonitrile thermally fragments to tert-Bu isocyanide and HCN. N-Cyanomethanimine H2C:NCN (II) has also been prepared by two methods: (i) pyrolysis of trimethylenetetrazole (III) at 500-800° and (ii) pyrolysis of ditetrazolopyrazine (IV) at 600-850°. Both methods are extremely clean. II is fully characterized by its IR spectrum in agreement with ab initio calculations and, in conjunction with other work, by its mass and millimeter-wave spectra. II is thermodynamically stable in the gas phase up to ca. 800° at low pressure and short contact times but polymerizes in the solid state above -100°. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).SDS of cas: 5098-14-6

The Article related to hydrogen cyanide dimer iminoacetonitrile cyanomethanimine, spectra iminoacetonitrile cyanomethanimine, ab initio iminoacetonitrile cyanomethanimine, polymerization iminoacetonitrile cyanomethanimine, photochem isomerization iminoacetonitrile, pyrolysis iminoacetonitrile cyanomethanimine precursor, photolysis iminoacetonitrile and other aspects.SDS of cas: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Seck, Pierre; Thomae, David; Perspicace, Enrico; Hesse, Stephanie; Kirsch, Gilbert published an article in 2012, the title of the article was Synthesis of new selenophene and thiazole analogues of the tacrine series.Application of 5098-14-6 And the article contains the following content:

New 2-aminoselenophene-3-carbonitriles and 5-amino-1,3-thiazole-4-carbonitriles were prepared and reacted with cycloalkanones to give tetrahydroselenolo[2,3-b]quinolines, cycloalkene-fused selenolo[3,2-e]pyridines, [1,3]thiazolo[5,4-b]quinolines, thiazolo[4,5-e]pyridines, and tetrahydro-[1,3]thiazolo[5,4-b]quinolines. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application of 5098-14-6

The Article related to selenophene tacrine analog preparation, thiazole tacrine analog preparation, hydroselenoloquinoline preparation, cycloalkene fused selenolopyridine preparation, thiazoloquinoline cycloalkene fused preparation, thiazolopyridine cycloalkene fused preparation, hydrothiazoloquinoline cycloalkene fused preparation and other aspects.Application of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 17, 1985, Hennen, William J.; Hinshaw, Barbara C.; Riley, Timothy A.; Wood, Steven G.; Robins, Roland K. published an article.Formula: C10H11N3O3S The title of the article was Synthesis of 4-substituted 5-amino-2-(β-D-ribofuranosyl)thiazoles and 4-substituted 5-amino-2-(β-D-ribofuranosyl)selenazoles, and their respective conversion into 2-(β-D-ribofuranosyl)thiazolo[5,4-d]pyrimidines and 2-(β-D-ribofuranosyl)selenazolo[5,4-d]pyrimidines. A new synthesis of tiazofurin and selenazofurin. And the article contained the following:

Anhydroallonothioate (I; Z = S) and -selenoate (I; Z = Se), prepared by treatment of anhydroallonimidate (I; Z = NH) with H2S and H2Se, underwent cyclocondensation with H2NCH(CN)2, NCCN(NH2)CONH2, or NCCH(NH2)CO2Et to give C-nucleosides II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2; X = S, Se, R = NH2, R1 = CO2Et). II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2) were further cyclized with H2NCH:NH or HC(OEt)3 to give thiazolo- and selenazolopyrimidine C-nucleosides, e.g., III (X = S, Se). II (X = S, Se, R = NH2, R1 = CO2Et) were converted in 2 steps into tiazofurin and selenazofurin (II; X = S, Se, R = H, R1 = CONH2), resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to aminoribofuranosylthiazole, aminoribofuranosylselanazole, thiazole c nucleoside, selenazole c nucleoside, ribofuranosylthiazolopyrimidine, ribofuranosylselenazolopyrimidine, thiazolopyrimidine ribofuranosyl, selenazolopyrimidine ribofuranosyl, tiazofurin, selenazofurin, nucleoside c thiazole selenazole and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 1, 2009, Ioannidis, Stephanos; Lamb, Michelle L.; Davies, Audrey M.; Almeida, Lynsie; Su, Mei; Bebernitz, Geraldine; Ye, Minwei; Bell, Kirsten; Alimzhanov, Marat; Zinda, Michael published an article.HPLC of Formula: 5098-14-6 The title of the article was Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors. And the article contained the following:

Pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines such as I (R = Me; X = N) and I (R = H; X = CH) are prepared as selective JAK2 kinase inhibitors for potential use as anticancer agents; the GI50 values for their JAK2 and JAK3 kinase inhibition are determined The activities of selected pyridineethyl- and pyrimidineethyl-substituted pyrazoleaminopyrazines in a functional phosphorylation model in mice and their inhibition of aurora B kinase, cyclin-dependent kinase 2, and TrkA are determined; the pharmacokinetics and pharmacodynamics of I (R = Me; X = N) and of I (R = H; X = CH) in rats and beagles are also determined The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).HPLC of Formula: 5098-14-6

The Article related to pyridineethyl pyrimidineethyl pyrazoleaminopyrazine preparation selective jak2 kinase inhibitor, structure pyridineethyl pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibition selectivity, pharmacokinetics pharmacodynamics pyrimidineethyl pyrazoleaminopyrazine jak2 kinase inhibitor and other aspects.HPLC of Formula: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts