Category: 50743-32-3

The author of 《Studies on antianaphylactic agents. 7. Synthesis of antiallergic 5-oxo-5H-[1]benzopyrano[2,3-b]pyridines》 were Nohara, Akira; Ishiguro, Toshihiro; Ukawa, Kiyoshi; Sugihara, Hirosada; Maki, Yoshitaka; Sanno, Yasushi. And the article was published in Journal of Medicinal Chemistry in 1985. Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:

5-Oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acids I and their tetrazole analogs II (R = H, Me, OH, amino; R1 = H, Me; R2 = H, Me, Et, Me2CH, Bu, Me3C, OMe; R1R2 = CH:CHCH:CH) were prepared from 4-oxo-4H-1-benzopyran-3-carbonitriles or 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes. They exhibited antiallergic activity both orally and i.v. in the passive cutaneous anaphylaxis test in rats. With I, the activity was influenced by the substituents at the 2-position and increased in the order: Me, OMe < NH2 < OH, H < NHOMe. Tetrazole series with II, 2-unsubsituted derivatives showed the highest activity. In addition to this study using 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile, there are many other studies that have used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 50743-32-3On March 25, 1986, Kubo, Keiji; Ukawa, Kiyoshi; Kuzuna, Seiji; Nohara, Akira published an article in Chemical & Pharmaceutical Bulletin. The article was 《Synthesis of (3-carboxy-5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-2-yl)acetic acid derivatives, potential antiarthritic agents》. The article mentions the following:

The title compounds I (R = 7-Et, 7-Cl, etc.; R1 = Me, Et, Na) possessed potent antiarthritic activity in the rat adjuvant arthritic model. The mode of action of these compounds differs from that of acidic antiinflammatory drugs. Various modifications in these compounds (e.g., elongation, removal, or substitution of the methylene group of the acetic acid moiety, substitution of the benzene ring) were made in order to study the structure-activity relationships. The structural requirements for the compounds to show activity are rather severe. In the experiment, the researchers used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 50743-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of C13H11NO2On November 12, 1999 ,《A Rare Acid-Promoted Elimination of O-Methyl Oximes: A Practical Synthesis of 3-Cyano-4-benzopyrones》 appeared in Journal of Organic Chemistry. The author of the article were Hsung, Richard P.; Zificsak, Craig A.; Wei, Lin-Li; Zehnder, Luke R.; Park, Francis; Kim, Michelle; Tran, Thuy-Trang T.. The article conveys some information:

3-Cyano-4-benzopyrones I (X = H, 6-Me2CH, 6-Cl, etc.) were prepared by acid-promoted elimination of O-Me oximes II (mixture of syn and anti). The experimental part of the paper was very detailed, including the reaction process of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Synthetic Route of C13H11NO2)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Synthetic Route of C13H11NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn October 25, 1985 ,《Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid (amoxanox)》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Ukawa, Kiyoshi; Ishiguro, Toshihiro; Kuriki, Hisashi; Nohara, Akira. The article contains the following contents:

Benzopyranopyridinecarboxylic acid I (R = CHMe2), a promising drug for bronchial asthma, was converted to various degradation products, I (R = CMe2OH, CHMeCH2OH, COMe), which were also synthesized from benzopyranonitrile. On testing for passive cutaneous anaphylaxis in rats, I (R = CHMe2, CMe2OH, COMe) were 260 times as potent as disodium cromoglycate (DSCG) while I (R = CMeCH2OH) was 1500 times as potent as DSCG. In the experimental materials used by the author, we found 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Silver(I)-Catalyzed Enantioselective [3+2]-Cycloaddition Reaction of α-Silylimines: A Facile Route to Quaternary-Carbon-Rich Scaffolds》 was written by Kesava-Reddy, Naredla; Golz, Christopher; Strohmann, Carsten; Kumar, Kamal. Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile And the article was included in Chemistry – A European Journal in 2016. The article conveys some information:

A silver-catalyzed highly enantioselective 1,3-dipolar cycloaddition reaction of α-silylimines with pyrone-based trisubstituted olefins was developed affording bi- and tricyclic α-quaternary-carbon-rich pyrano-pyrrolidines in excellent yields. The tricyclic benzopyrone adducts thus obtained were efficiently transformed into highly complex tetracyclic scaffolds supporting four consecutive stereogenic centers with three quaternary carbons. The experimental process involved the reaction of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Enantioselective H-bond-directing approach for trienamine-mediated reactions in asymmetric synthesis》 was published in Angewandte Chemie, International Edition in 2012. These research results belong to Albrecht, Lukasz; Cruz Acosta, Fabio; Fraile, Alberto; Albrecht, Anna; Christensen, Jannie; Jorgensen, Karl Anker. HPLC of Formula: 50743-32-3 The article mentions the following:

The first H-bond-directed trienamine-mediated [4+2] cycloaddition was developed, thereby demonstrating the viability of such an activation strategy. The reaction between diversely substituted 2,4-dienals and 3-cyanochromones proceeded smoothly and in a highly stereoselective manner in the presence of a squaramide-containing aminocatalyst. Furthermore, it was demonstrated that the obtained cycloadducts can be chemo- and diastereoselectively transformed into polycyclic products with high mol. and stereochem. complexity that possess up to five stereogenic centers. An unexpected stereochem. outcome of the reaction was observed and a rationalization of the results was provided. In the experimental materials used by the author, we found 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3HPLC of Formula: 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.HPLC of Formula: 50743-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reddy, G. Jagath; Latha, D.; Thirupathaiah, C.; Rao, K. Srinivasa published an article in Organic Preparations and Procedures International. The title of the article was 《An efficient one step conversion of 3-formylchromones into 3-cyanochromones》.Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:

A one step conversion of 3-formylchromones into 3-cyanochromones. Substituted 3-formylchromones were heated with hydroxylamine hydrochloride in refluxing acetonitrile in the presence of sodium iodide to give 3-cyanochromones in good yields. The results came from multiple reactions, including the reaction of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn March 31, 1986, Hayashi, Nobuyoshi; Imanishi, Masayuki published an article in Journal of Labelled Compounds and Radiopharmaceuticals. The article was 《Synthesis of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b][2-14C]pyridine-3-carboxylic acid (AA-673-14C)》. The article mentions the following:

Ester I (R = Et) was prepd by cyclocondensation of NC14CH2CO2Et with cyanochromone II in the presence of piperidine. I (R = Et) was hydrolyzed to give the title compound (I, R = H). After reading the article, we found that the author used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Safety of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Safety of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts