Category: 50743-32-3

Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn May 31, 2022, Yang, Hongchen; Zhang, Lu; Xu, Xiaoyong; Shao, Xusheng; Li, Zhong published an article in Synlett. The article was 《Acid-Mediated Synthesis of Chromeno[2,3-b]pyridine Derivatives via Condensation of 2-Amino-3-formylchromones and 1-(Methylthio)-2-nitroenamine Derivatives》. The article mentions the following:

A convenient and effective protocol has been proposed for the synthesis of chromeno[2,3-b]pyridines I (R1 = H, i-Pr; R2 = Me, Et, PhCH2, etc.) via the CF3SO3H-catalyzed annulation of substituted 2-amino-3-formylchromones II and various 1-(methylthio)-2-nitroenamines R2NHC(SMe):CHNO2. This method is time-efficient, convenient, high-yielding and exhibits a good functional group compatibility. In addition to this study using 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile, there are many other studies that have used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Name: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cascade synthesis of novel functionalized pyridine-fused coumarins in aqueous medium》 was published in RSC Advances in 2014. These research results belong to Xiang, Haoyue; Chen, Jianyang; Miao, Zehong; Yang, Chunhao. Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The article mentions the following:

A simple, convenient and efficient catalyst-free approach for the synthesis of a novel series of pyridine-fused coumarins, e.g., I, via a cascade reaction from chromone derivatives and Et amidinoacetate in an environmentally friendly aqueous medium was developed. This cascade reaction involves a chemoselective Michael addition-heterocyclization-intramol. cyclization sequence. The experimental part of the paper was very detailed, including the reaction process of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ukawa, Kiyoshi; Ishiguro, Toshihiro; Wada, Yoshikazu; Nohara, Akira published an article in Heterocycles. The title of the article was 《Synthesis of 5-oxo-5H-[1]benzopyrano[4,3-b]pyridine derivatives》.Product Details of 50743-32-3 The author mentioned the following in the article:

Oxobenzopyranopyridinecarboxamides I (R = H, Me, Et, Me2CH; R1 = H, Me) were synthesized by the reaction of oxobenzopyrancarbonitriles II with malonamide in the presence of NaOMe. Compounds I were also converted into carboxylic acids and tetrazole derivatives, some of which have antiallergic activity. The structures of I and their derivatives were confirmed by IR and NMR spectra and by X-ray crystallog. anal. The experimental part of the paper was very detailed, including the reaction process of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Product Details of 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Product Details of 50743-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C13H11NO2On June 3, 2016, Danda, Adithi; Kesava-Reddy, Naredla; Golz, Christopher; Strohmann, Carsten; Kumar, Kamal published an article in Organic Letters. The article was 《Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction》. The article mentions the following:

The catalytic addition of the amino acid derived bifunctional N-acylaminophosphine to an α-substituted allene ester generated a zwitterionic dipole that engaged the vinylogous ester function of 3-cyanochromones in a [4 + 2] annulation reaction to deliver tetrahydroxanthones embodying three consecutive chiral centers in high yields and with excellent enantioselectivities. The established asym. synthesis further paves the way to two different classes of complex, sp3-rich tetracyclic benzopyrans via efficient cascade reactions. The experimental process involved the reaction of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Computed Properties of C13H11NO2)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Computed Properties of C13H11NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn May 26, 2008, Rashid, Muhammad A.; Rasool, Nasir; Appel, Bettina; Adeel, Muhammad; Karapetyan, Vahuni; Mkrtchyan, Satenik; Reinke, Helmut; Fischer, Christine; Langer, Peter published an article in Tetrahedron. The article was 《Synthesis of 1-azaxanthones by condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-(cyano)benzopyrylium triflates and subsequent domino retro-Michael/nitrile-addition/heterocyclization’ reaction》. The article mentions the following:

Functionalized 1-azaxanthones (5-oxo-5H-[1]-benzopyrano[2,3-b]pyridines), e.g. I, were prepared by TMSOTf-mediated condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3-cyanochromones and subsequent base-mediated domino retro-Michael/nitrile-addition/heterocyclization reaction.6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 50743-32-3On May 1, 1981 ,《Synthesis of 3-substituted-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine derivatives》 appeared in Heterocycles. The author of the article were Ishiguro, Toshihiro; Ukawa, Kiyoshi; Sugihara, Hirosada; Nohara, Akira. The article conveys some information:

Oxobenzopyranopyridines I (R = H, 7-Me, 7-Et, 7-Me2CH, 7-Me3C, 7-Cl, 7-Me2CHO, 9-MeO, R1 = H; R = 7-Me, R1 = 9-Me; R2 = CN, CHO, alkoxycarbonyl) were prepared by cyclization reactions of the corresponding benzopyrancarboxaldehydes II with acetylenes or active methylene compounds Thus, cyclization of II (R = R1 = H) (III) with HCCCN or HCCCO2Et in DMF gave 32% I (R = R1 = H, R2 = CN) and 49% I (R = R1 = H, R2 = CO2Et), resp. Cyclocondensation of III with CH2[CH(OMe)2]2 in HCO2H containing F3B.OEt2 gave 10% I (R = R1 = H, R2 = CHO). I (R = H; R1 = 7-Et, 7-Me2CH; R2 = CN) were also prepared by hydrogenolysis of the corresponding 2-chloro derivatives of I (R2 = CN). In the part of experimental materials, we found many familiar compounds, such as 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application of 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application of 50743-32-3 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Langer, Peter; Appel, Bettina published an article in Tetrahedron Letters. The title of the article was 《Efficient synthesis of benzopyrano[2,3-b]pyridines by sequential reactions of 1,3-bis-silyl enol ethers with 3-cyanobenzopyrylium triflates》.Recommanded Product: 50743-32-3 The author mentioned the following in the article:

Benzopyrano[2,3-b]pyridines were efficiently prepared by condensation of 1,3-bis-silyl enol ethers with 3-cyanobenzopyrylium triflates and subsequent domino retro-Michael-lactonization-aldol reactions. For example, 2-ethoxycarbonylmethyl-5-oxo-5H-benzopyrano[2,3-b]pyridine was prepared in 46% yield from 3-cyano-4-benzopyranone and 1,3-bis(trimethylsilyloxy)-1,3-butadiene.6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 50743-32-3) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 50743-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2020,Organic Chemistry Frontiers included an article by Xiao, Qiang; Liu, Jin; Nie, Jia-Hui; Kong, Ling-Bin; Lin, Jun; Yan, Sheng-Jiao. Application of 50743-32-3. The article was titled 《Silver-catalyzed cascade reactions of 3-cyanochromone with 1,1-enediamines: synthesis of highly functionalized 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines》. The information in the text is summarized as follows:

A novel protocol for the construction of highly functionalized 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines I [R = H, Me, Cl, Br, i-Pr; R1 = Me, Ph, 4-ClC6H4(CH2)2, etc.] (PCPMDs) from 3-cyanochromones with 1,1-enediamines via an unprecedented cascade reaction was developed by simply refluxing under the catalysis of silver carbonate. As a result, a series of 2-(pyridin-3-yl)-chromeno[2,3-d]pyrimidines I was obtained through a novel cascade reaction involving an amazing electrocyclization mechanism of a cyano group with α,β-unsaturated nitriles. This reaction formation of compounds I was accompanied by the formation of four bonds and the cleavage of one bond in one step. This protocol could be used for the synthesis of various pyridin-3-yl-substituted complex pyrimidine derivatives, and it was suitable for combinatorial and parallel synthesis of PCPMD drugs or natural-like products. In the experiment, the researchers used 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application of 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application of 50743-32-3 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances》 were Nohara, Akira; Kuriki, Hisashi; Saijo, Taketoshi; Sugihara, Hirosada; Kanno, Morio; Sanno, Yasushi. And the article was published in Journal of Medicinal Chemistry in 1977. Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The author mentioned the following in the article:

Of 28 title compounds (I; R=H, lower alkyl, Cl, cyclohexyl, OMe, Me2N, OAc, CO2Et, NO2, OH, OBu) and analogs, prepared from the appropriate carboxaldehydes by reaction with NH2OH to give the nitriles followed by cyclization with NaN3 in the presence of AlCl3, most were potent inhibitors of the rat passive cutaneous anaphylaxis reaction. Seven of the compounds were 4-10 times as active as di-Na cromoglycate when administered i.v., and several had oral activity. Structure-activity relations are discussed. In the experimental materials used by the author, we found 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application In Synthesis of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2004,Heterocyclic Communications included an article by Reddy, G. Jagath; Latha, D.; Rao, K. Srinivasa. SDS of cas: 50743-32-3. The article was titled 《A mild and facile method for the synthesis of 3-cyanochromones from oximes derived from 3-formylchromones using dimethylformamide – thionylchloride complex》. The information in the text is summarized as follows:

A mild and facile method for the synthesis of 3-cyanochromones from oximes derived from 3-formylchromones using Dimethylformamide-thionylchloride complex is herein reported.6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3SDS of cas: 50743-32-3) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. SDS of cas: 50743-32-3 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts