Category: 50670-64-9

These common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H8N2

Add a solution of sodium nitrile (2.1 g, 31 mmol) in water (15 mL) drop wise at 5 C to a stirred solution of 5-amino-2-methylbenzonitrile (4.0 g, 31 mmol) in 33% sulfuric acid (45 mL) and keep the temperature below 5 C. In a separate flask, add concentrated sulfuric acid (30 mL) cautiously to a stirred solution of sodium sulfate (21.7 g, 153 mmol) in water (15 mL) and heat the mixture to reflux. Add the prepared diazonium solution to the re fluxing mixture in portions and continue refluxing for 2 hours. Cool the mixture slowly to room temperature and stir overnight. Extract the mixture with ethyl acetate (2 x 100 mL) and wash the combined organic extracts with water (2 x 150 mL) and 10% NaOH water solution (3 x 100 mL). Acidify the combined NaOH extracts with concentrated HC1 and then extract with ethyl acetate (2 x 200 mL). Dry the organic extracts over Na2S04 and concentrate under reduced pressure to give the title compound as a yellow solid (2.4 g, 60%): ES/MS (m/z) 134 (M+H), which is used directly without further purification.

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; LIU, Kevin Kun-Chin; XIE, Yinong; WU, Liang; ZHOU, Guoqiang; WO2015/89800; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 50670-64-9, The chemical industry reduces the impact on the environment during synthesis 50670-64-9, name is 5-Amino-2-methylbenzonitrile, I believe this compound will play a more active role in future production and life.

The 2,4-dicyanobenzyl bromide (melting point 106) can be obtained by bromination of 2,4-dicyanotoluene (melting point 142-143) with bromine in chlorobenzene with ultra-violet irradiation. The 2,4-dicyanotoluene can be formed from 3-cyano-4-methyl-1-aminobenzene by the Sandmeyer reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sandoz Ltd.; US4032558; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 50670-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50670-64-9, name is 5-Amino-2-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 22 5-Bromo-2-methylbenzonitrile Water (13.5 mL), HBr (74%, 14.4 mL) and 5-amino-2-methylbenzonitrile (2.0 g, 15.1 mmol) dissolved in water (24 mL) was added to a flask and heated to 50 C. for 20 min. Then the mixture was cooled to 0~5 C., and a solution of NaNO2 (1.2 g, 17.4 mmol) in water was added. The reaction mixture was stirred for 10 min at 0~5 C., then was warmed to 40 C. A solution of CuBr (6.5 g, 45.1 mmol) in water (36 mL) and HBr (7.2 mL) was added to the mixture, and refluxed for 2 h. The mixture was extracted with AcOEt, and the organic layer was washed by saturated NaHCO3 solution and brine, and dried over Na2SO4. The crude product was purified by flask chomatograph (PE:EA=50:1), obtaining 2.3 g of 5-bromo-2-methylbenzonitrile as a white solid (yield: 77%). 1H NMR (400 MHz, CDCl3) delta 7.72 (s, 1H), 7.59 (d, J=8.0 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H), 2.51 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Glaxo Group Limited; US2009/203677; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50670-64-9, name is 5-Amino-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 50670-64-9

General procedure: A mixture of compound 2 (1.82 g, 8.8 mmol) and DMF (30 drops) in SOCl2 (50 mL) was refluxed for 7 h. The excess SOCl2 was removed by vacuum distillation. The residue was stirred with diethyl ether, filtered, washed, and dried to give compound 3 as a beige solid (1.83 g, 92%). A mixture of compound 3 and various amines in 2-propanol or DMF was refluxed. Upon completion of the reaction, it was cooled in an ice bath. The residue was filtered, washed, and dried to isolate the product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yang, Su Hui; Khadka, Daulat Bikram; Cho, Suk Hee; Ju, Hye-Kyung; Lee, Kwang Youl; Han, Ho Jae; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 968 – 977;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Amino-2-methylbenzonitrile

Add a solution of sodium nitrile (2.1 g, 31 mmol) in water (15 mL) drop wise at 5 C to a stirred solution of 5-amino-2-methylbenzonitrile (4.0 g, 31 mmol) in 33% sulfuric acid (45 mL) and keep the temperature below 5 C. In a separate flask, add concentrated sulfuric acid (30 mL) cautiously to a stirred solution of sodium sulfate (21.7 g, 153 mmol) in water (15 mL) and heat the mixture to reflux. Add the prepared diazonium solution to the re fluxing mixture in portions and continue refluxing for 2 hours. Cool the mixture slowly to room temperature and stir overnight. Extract the mixture with ethyl acetate (2 x 100 mL) and wash the combined organic extracts with water (2 x 150 mL) and 10% NaOH water solution (3 x 100 mL). Acidify the combined NaOH extracts with concentrated HC1 and then extract with ethyl acetate (2 x 200 mL). Dry the organic extracts over Na2S04 and concentrate under reduced pressure to give the title compound as a yellow solid (2.4 g, 60%): ES/MS (m/z) 134 (M+H), which is used directly without further purification.

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; LIU, Kevin Kun-Chin; XIE, Yinong; WU, Liang; ZHOU, Guoqiang; WO2015/89800; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 50670-64-9, name is 5-Amino-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50670-64-9, Product Details of 50670-64-9

General procedure: mixture of 4-chloroquinazolines derivatives 10a-10j(5 mmol) and substituted anilines (6 mmol) in isopropanol(45 mL) was stirred at reflux for 3 h. The reaction mixture wascooled to room temperature and the resultant precipitate was collectedby filtration. The solid was further dried in vacuum to givethe compounds a-j.

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Electric Literature of 50670-64-9,Some common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of 3-((4-(1,8-naphthyridin-2-yl)phenoxy)methyl)benzoic acid (8) (100 mg, 0.28 mmol)in dimethyl formamide (2 mL), tetrahydrofuran (2 mL)was added corresponding anilines R-NH2 (9a-9k) (0.42mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (0.42 mmol) and 4-dimethylaminopyridine(0.02 mmol) at room temperature and stirred at room temperature for 16 h. The reaction mixture was poured into ice water (4 mL) and extracted with ethyl acetate (3× 5 mL). The combined organic layers were washed with water (5 mL) followed by brine solution (5 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure, crude material was washed with 50% of dichloromethane in pet ether to afford the pure compounds(10a-10k). Yields of the products varied between 40 and 75%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-methylbenzonitrile, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 50670-64-9, name is 5-Amino-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50670-64-9, Formula: C8H8N2

To a stirred solution of 5-Amino-2-methylbenzonitrile (4.00 g, 30.27 mmol) in 33% sulfuric acid (45 mL) was added a solution of sodium nitrite (2.09 g, 30.27 mmol) in water (15 mL) at 5C. The temperature was kept below 5C. In a separated flask, concentrated sulfuric acid (30 mL) was added cautiously to a stirred solution of sodium sulfate (21.50 g, 151.33 mmol) in water (15 mL). The slurry was heated to reflux. The prepared diazonium salt was added dropwise to the refluxing mixture and the reflux was continued for 2 hours. The mixture was cooled slowly to room temperature. The mixture was extracted with ethyl acetate (2 x 100 mL) and the combined extracts were washed with water (2 x 150 mL). The organic layer was extracted with aqueous 10% NaOH solution (2 x 100 mL). The alkaline extract was acidified with cone. HC1 and extracted with EtOAc (2 x 100 mL). The combined organic layers were dried over MgSCL, filtered and the solvent was evaporated in vacuo to afford the title compound as a red solid and pure enough to be used as such (2400 mg, 60% yield). 1H NMR (300MHz, CHCL-d) 9.46 (bs, 1H), 7.16 (d, / = 8.4 Hz, 1H), 7.06 (d, / = 2.7 Hz, 1H), 6.97 (dd, / = 8.4 and 2.7 Hz, 1H ), 2.45 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H8N2

A mixture of 2-(methylthio)-6-propylpyrimidin-4(3H)-one (5 g, 27.1 mmol) prepared in Step 1 of Preparation 1 and 5-amino-2-methylbenzonitrile (7 g, 53 mmol) was stirred at 160 C. overnight. The reaction mixture was cooled to room temperature and then ethanol (30 ml) was added thereto. The reaction mixture was stirred for 1 hour and then filtered to give 6.3 g of the titled compound as a pale yellow solid. [0525] 1H-NMR (400 MHz, CD3OD) delta 8.12 (d, 1H), 7.70-7.60 (m, 1H), 7.35 (d, 1H), 5.80 (s, 1H), 2.50-2.40 (m, 5H), 1.73 (q, 2H), 0.99 (t, 3H)

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 50670-64-9, A common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The respective amine (1.1 equivalent) and methyl thioglycolate(1.0 equivalent) were added to an ice-cooled solution of 1,19-carbonyldiimidazole (1.1 equivalent) in 30 ml of absolute methylenechloride. The reaction mixture was stirred at room temperature for3 days and then washed three times with 3 M HCl. The solvent wasremoved, and the crude solid was purified by recrystallization fromtoluene or by flash column chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Oppermann, Sina; Schrader, Florian C.; Elsaesser, Katharina; Dolga, Amalia M.; Kraus, Anna Lena; Doti, Nunzianna; Wegscheid-Gerlach, Christof; Schlitzer, Martin; Culmsee, Carsten; Journal of Pharmacology and Experimental Therapeutics; vol. 350; 2; (2014); p. 273 – 289;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts