Category: 50397-74-5

Some common heterocyclic compound, 50397-74-5, name is 4-Amino-3-bromobenzonitrile, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrN2

General procedure: A mixture of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (247 mg, 1.0 mmol), 2-bromo-4-methoxyaniline (303 mg, 1.5 mmol) and lithium perchlorate (190 mg, 1.7 mmol) were taken in acetonitrile (3.0 mL). The reaction mixture was heated to 90 C for 18 h. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with water. The organic layer was dried over sodium sulfate and concentrated under reduced pressure, and the product was purified by column chromatography (silica gel, 50% EtOAc/hexanes) to provide benzyl 4-(((2-bromo-4-methoxyphenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate, 5c (358 mg, 80%) as a colourless syrup.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 50397-74-5, its application will become more common.

Electric Literature of 50397-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50397-74-5, name is 4-Amino-3-bromobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1 :- Preperation of (E)-methyl 3-(2-amino-5-cyanophenyl)acrylate To a mixture of 4-amino-3-bromobenzonitrile (10.0 g, 0.050 mmol) and methyl acrylate (9.19 mL, 0.101 mmol) in acetonitrile (200 mL) was added palladium acetate (0.568 g, 0.0025 mmol) and tri-o-tolyl phosphine (1.54 g, 0.005 mmol) and Et3N (14.64 mL, 0.105 mmol). The reaction mixture was heated to reflux for 48 h. The reaction mass was filtered through celite and washed the bed with ethyl acetate. The filtrate was concentrated to afford 6.0 g of title product. 1H NMR (300 MHz, DMSO): delta 7.92 (s, 1H), 7.82-7.77 (d, = 15.6 Hz, 1H), 7.41-7.38 (d, = 8.7 Hz, 1H), 6.77- 6.74(d, = 8.7 Hz, 1H), 6.64 (s, 2H), 6.56-6.51 (d, = 15.6 Hz, 1H), 3.70 (s, 3H).

The synthetic route of 4-Amino-3-bromobenzonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 50397-74-5, The chemical industry reduces the impact on the environment during synthesis 50397-74-5, name is 4-Amino-3-bromobenzonitrile, I believe this compound will play a more active role in future production and life.

Diethyl ethoxymethylenemalonate (8.23 g, 38.1 mmol) was added to a solution of 1 (5.00 g, 25.4 mmol) in 30 mL of toluene. The mixture was then heated to reflux overnight with the condenser open to the air. The resulting solution was cooled down to room temperature and poured into 100 mL of hexanes. The white precipitate was collected and washed with hexanes (3 * 30 mL) to yield 11.9 g of an off-white solid as the desired product. MS ESI (m/z) 367 (M + 1)+; 1H NMR (CDCl3, 300 MHz): delta 11.44 (d, 1H, J = 12.6 Hz), 8.44 (d, 1H, J = 12.9 Hz), 7.86 (d, 1H, J = 1.8 Hz), 7.63 (dd, 1H, J1 = 1.8 Hz, J2 = 8.7 Hz), 7.33 (d, 1H, J = 8.4 Hz), 4.35 (q, 2H, J = 6.9 Hz), 4.27 (q, 2H, J = 6.9 Hz), 1.38 (t, 3H, J = 6.9 Hz), 1.33 (t, 3H, J = 6.9 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-bromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fiorito, Jole; Saeed, Faisal; Zhang, Hong; Staniszewski, Agnieszka; Feng, Yan; Francis, Yitshak I.; Rao, Sudha; Thakkar, Devarshi M.; Deng, Shi-Xian; Landry, Donald W.; Arancio, Ottavio; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 285 – 294;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 50397-74-5, name is 4-Amino-3-bromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50397-74-5, Product Details of 50397-74-5

General procedure: To provide nano-structures of (1), (2), and (3) by sonochemical method, a high-density ultrasonic probe immersed directly into the methanolic solution of Lx (25mL, 0.025M) in double distilled water, then into this solution, a proper volume of methanolic solution of AgNO3 (25mL, 0.025M) was added in a dropwise manner. The solution was ultrasonically irradiated with the power of 12 W for 1h. The obtained precipitates were filtered, subsequently washed with double distilled water and then dried at room temperature. The nanoparticles were characterized by powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-bromobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zisti, Fatemeh; Tehrani, Alireza Azhdari; Alizadeh, Robabeh; Abbasi, Hamed; Morsali, Ali; Eichhorn, S. Holger; Journal of Solid State Chemistry; vol. 271; (2019); p. 29 – 39;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts