Category: 49540-34-3

Mlotkowska, B. published the artcileSolid sodium hydroxide/potassium carbonate – a new highly effective base for phase-transfer catalyzed N-alkylation of diphenylphosphinic hydrazide, HPLC of Formula: 49540-34-3, the publication is Tetrahedron Letters (1978), 4731-4, database is CAplus.

Ph₂P(O)NHNH₂ underwent phase-transfer-catalyzed N-alkylation with RBr (R = Me, Et, Pr, iso-Pr, Bu, iso-Bu, sec-Bu, CH₂:CHCH₂, CHCCH₂, CH₂Ph) in boiling C₆H₆ containing solid NaOH-K₂CO₃, to give 27-94% Ph₂P(O)NRNH₂ (I). Subsequent treatment of I (R = Et, Pr, iso-Pr, Bu, CH₂:CHCH₂, CH₂Ph) with 15% HCl gave Ph₂P(O)OH and 82-99% RNHNH₂.2HCl.

Tetrahedron Letters published new progress about 49540-34-3. 49540-34-3 belongs to nitriles-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethylhydrazine dihydrochloride, and the molecular formula is C2H10Cl2N2, HPLC of Formula: 49540-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Francisco, Ma. Elena Y. published the artcileSynthesis and Structure-Activity Relationships of Amide and Hydrazide Analogues of the Cannabinoid CB₁ Receptor Antagonist N-(Piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716), Synthetic Route of 49540-34-3, the publication is Journal of Medicinal Chemistry (2002), 45(13), 2708-2719, database is CAplus and MEDLINE.

Analogs of the biaryl pyrazole N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, SR141716 (I) were synthesized to investigate the structure-activity relation (SAR) of the aminopiperidine region. The structural modifications include the substitution of alkyl hydrazines, amines, and hydroxyalkylamines of varying lengths for the aminopiperidinyl moiety. Proximity and steric requirements at the aminopiperidine region were probed by the synthesis of analogs that substitute alkyl hydrazines of increasing chain length and branching. The corresponding amide analogs were compared to the hydrazides to determine the effect of the second nitrogen on receptor binding affinity. The N-cyclohexyl amide (II) represents a direct methine for nitrogen substitution for I, reducing the potential for heteroatom interaction, while the morpholino analog adds the potential for an addnl. heteroatom interaction. The series of hydroxyalkyl amides of increasing chain length was synthesized to investigate the existence of addnl. receptor hydrogen binding sites. In displacement assays using the cannabinoid agonist [³H](1R,3R,4R)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl) cyclohexan-1-ol (CP 55 940) or the antagonist [³H]I,II exhibited the highest CB₁ affinity. In general, increasing the length and bulk of the substituent was associated with increased receptor affinity and efficacy (as measured in a GTP-γ-[³⁵S] assay). However, in most instances, receptor affinity and efficacy increases were no longer observed after a certain chain length was reached. A quant. SAR study was carried out to characterize the pharmacophoric requirements of the aminopiperidine region. This model indicates that ligands that exceed 3 Å in length would have reduced potency and affinity with respect to I and that substituents with a pos. charge d. in the aminopiperidine region would be predicted to possess increased pharmacol. activity.

Journal of Medicinal Chemistry published new progress about 49540-34-3. 49540-34-3 belongs to nitriles-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethylhydrazine dihydrochloride, and the molecular formula is C2H10Cl2N2, Synthetic Route of 49540-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Monguzzi, R. published the artcileSynthesis of new α-hydrazinoarylacetic acids and derivatives, Related Products of nitriles-buliding-blocks, the publication is Farmaco, Edizione Scientifica (1976), 31(8), 549-60, database is CAplus and MEDLINE.

α-Hydrazinoarylacetic acids, e.g., PhCH(NMeNH2)CO2H, were prepared by reaction of α-bromoarylacetic acids with N2H4, alkylhydrazines and carbobenzyloxyhydrazines. Na-Hg reduction of α-hydrazono-2-thienylacetic acid and of α-hydrazono-(2,5-dichloro-3-thienyl)acetic acid gave α-hydrazino-2-thienylacetic acid and α-hydrazino-(2-chloro-4-thienyl)acetic acid. PhCHBrCO2H and PhCH2O2CNHNH2 gave PhCH(NHNHCO2CH2Ph)CO2H, which with 2,4-(O2N)2C6H3OH and dicyclohexylcarbodiimide gave 16% I (R = PhCH2O2C) (and smaller amounts of II), which was hydrogenolyzed with Pd/C to 53% I (R = H).

Farmaco, Edizione Scientifica published new progress about 49540-34-3. 49540-34-3 belongs to nitriles-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethylhydrazine dihydrochloride, and the molecular formula is C2H10Cl2N2, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Fairley, Gary published the artcileOne-pot synthesis of novel 1,2,6,7-tetrahydro-3H-pyrazolo[4,3-c]pyridine-3,4(5H)-diones, SDS of cas: 49540-34-3, the publication is Tetrahedron Letters (2018), 59(39), 3574-3578, database is CAplus.

A facile synthesis of novel 1,2,6,7-tetrahydro-3H-pyrazolo[4,3-c]pyridine-3,4(5H)-diones was achieved. The operationally simple procedure, using readily available intermediates, allows for rapid derivatization of the pharmacophore with alkyl, aryl and heteroaryl substituents.

Tetrahedron Letters published new progress about 49540-34-3. 49540-34-3 belongs to nitriles-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethylhydrazine dihydrochloride, and the molecular formula is C2H10Cl2N2, SDS of cas: 49540-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts