Electric Literature of 493038-93-0, These common heterocyclic compound, 493038-93-0, name is 2-(3-Chloro-5-fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of (3-(trifluoromethyl)phenyl)acetonitrile (45.2 g,244 mmol) and diethyl dithiophosphate (50.0 g, 269 mmol) in 4 N HCl solution in EtOAc (500 mL, 2000 mmol) was stirred at room temperature overnight. The mixture was washed with water, 1 N aqueous NaOH solution, and brine, dried over Na2SO4, and concentrated in vacuo. The residue was triturated with hexane with ice-bath cooling. The precipitate was collected by filtration followed by washing with hexane to give 35.0 g (65%) of 6a as colorless solid.
Statistics shows that 2-(3-Chloro-5-fluorophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 493038-93-0.
Reference:
Article; Tokumaru, Kazuyuki; Ito, Yoshiteru; Nomura, Izumi; Nakahata, Takashi; Shimizu, Yuji; Kurimoto, Emi; Aoyama, Kazunobu; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry; vol. 25; 12; (2017); p. 3098 – 3115;,
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