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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shafaati, A.; Clark, B. J. researched the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ).Recommanded Product: 4897-25-0.They published the article 《Determination of azathioprine and its related substances by capillary zone electrophoresis and its application to pharmaceutical dosage forms assay》 about this compound( cas:4897-25-0 ) in Drug Development and Industrial Pharmacy. Keywords: azathioprine determination pharmaceutical capillary zone electrophoresis; imidazole azathioprine determination capillary zone electrophoresis. We’ll tell you more about this compound (cas:4897-25-0).

The development of a stability-indicating capillary zone electrophoresis (CZE) method for the determination of azathioprine (AZA) and its related substances in bulk and dosage forms is described. Theophylline was used as an internal standard to improve quant. results. The method was fully validated in terms of repeatability (RSD for migration time and peak area ratio were 0.15 and 0.60%, resp.), reproducibility (RSD of peak area ratio was 0.84%), linearity at 2 ranges of the azathioprine concentration, limits of detection and quantitation, and robustness. The method was applied for determination of the drug in bulk and a com. tablet dosage form (recovery 98.3-101.3%) and in powder for injection (recovery 98.7-100.6%). The method was fast and reliable for the determination of AZA and its related substances in bulk and dosage forms.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Fenxi Ceshi Xuebao called Determination of ten nitroimidazole residues in royal jelly by high performance liquid chromatography tandem mass spectrometry, Author is Xie, Wen; Chen, Xiaomei; Ding, Huiying; Hou, Jianbo; Xi, Junyang; Qian, Yan, the main research direction is royal jelly high performance liquid chromatog tandem mass spectrometry; nitroimidazole residue.Electric Literature of C4H4ClN3O2.

Nitroimidazoles and their hydroxy metabolites are banned substances with antibiotic and anticoccidial activity. They are suspected to be carcinogenic and mutagenic. In this paper, a rapid, sensitive and selective method for the determination of ten nitroimidazole residues, including dimetridazole(DMZ), 2-hydroxymethyl-1-methyl-5-nitroimidazole(HMMNI) or dimetridazole-OH(DMZOH), metronidazole(MNZ), metronidazole-OH(MNZOH), ronidazole(RNZ), 5-nitrobenzimidazole(NBI), ipronidazole(IPZ), ipronidazole-OH(IPZOH), 2-methyl-5-nitroimidazole(MNI) and 5-chloro-1-methyl-4-nitroimidazole(CMNI) in royal jelly was established by liquid chromatog.-tandem mass spectrometry (LC-ESI MS/MS). Methanol was used to precipitate protein, the supernatant solution was extracted with Et acetate under weak basic condition and cleaned up with Oasis(HLB) and C18 columns. The quant. detection was performed by LC-MS/MS on multiple reaction monitoring(MRM) mode under pos.-ion electrospray ionization. The isotope internal standards(D3-DMZOH, D3-DMZ, D3-RNZ, D3-IPZOH, D3-IPZ) were added into the sample solutions, and isotope dilution internal standard method or external standard method was used for quantitation anal. The results showed that the calibration curves of ten nitroimidazole residues were linear in the range of 5.0-60μg/kg with correlation coefficients more than 0.999. The recoveries of ten nitroimidazole residues at the spiked levels of 10, 20 and 50μg/kg were between 70% and 105% with RSDs less than 12.7%, and the quantitation limits were all 10μg/kg. The method was specific and accurate, and was suitable for the determination and confirmation of nitroimidazole residues in royal jelly samples.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hamlyn, Richard J.; Jones, Richard H.; Ramsden, Christopher A. researched the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ).SDS of cas: 4897-25-0.They published the article 《Carbon-carbon bond formation via thermal intermolecular hydrogen atom transfer: two serendipitous heterocyclic examples》 about this compound( cas:4897-25-0 ) in Perkin 1. Keywords: chloro nitro thiophene reaction benzyl dihydro imidazole; imidazolyl thienyl methanol preparation crystal mol structure. We’ll tell you more about this compound (cas:4897-25-0).

Formation of an anomalous 3-nitrothiophene product, encountered during the preparation of potential bioreductive anti-cancer agents, is rationalized in terms of a hydrogen atom transfer mechanism which also accounts for the unexpected formation of previously described 5,5′-biimidazoles. Thus, reaction of 2-chloro-3-nitrothiophene with 2-benzyl-4,5-dihydro-1H-imidazole in propionitrile containing mol. sieves gave 62% imidazolylthienylmethanol I, which was x-ray crystallog. characterized.

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Computed Properties of C4H4ClN3O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about The effect of electron-affinic radiosensitizers on ATP levels in V79 379A Chinese hamster cells. Author is Hodgkiss, R. J..

The ATP and nonprotein thiol content of Chinese hamster V79 379A cells were studied following treatment with electron-affinic radiosensitizers, i.e., misonidazole, Ro 05-9963, MOA-16, metronidazole, nitrofurentoin, CMNI, and 2,4-DNP. In cells in hypotonic medium, misonidazole, 2,4-DNP, and MOA-16 induced a concentration-dependent increase in cellular ATP after a 1-2-h lag paralleling the time courses of toxicity and nonprotein thiol depletion. Similar results were observed with nitrofurantoin, CMNI, and Ro 05-9963.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about Unit cell dimensions and space group of twinned crystals of 1-methyl-4-nitro-5-chloroimidazole, the main research direction is structure methylnitrochloroimidazole; imidazole methylnitrochloro structure; nitrochloromethylimidazole structure; chloronitromethylimidazole structure.Product Details of 4897-25-0.

The crystallog. parameters of the monoclinic title compound (I) (m.p. 147-8°) are a 3.826, b 14.369, c 11.569 Å, β 94.35.degree., d. (exptl.) = 1.682, Z = 4, d.(calculated) = 1.692, space group P21/c. Crystals of I were twinned.

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COA of Formula: C4H4ClN3O2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Author is Becker, Irwin.

This paper describes the preparation of twenty-eight derivatives of 1-(2-pyrimidinyl)piperazine, e.g. I, as potential antianxiety, antidepressant, and antipsychotic agents. In twenty-six of the preparations, a chloro-substituted nitrogen heterocycle was caused to reacted with an excess of 1-(2-pyrimidinyl)piperazine in the absence of solvent.

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Abu Safieh, Kayed A.; Darras, Fouad H.; Ayoub, Mikdad T.; El-Abadelah, Mustafa M.; Sabri, Salim S.; Voelter, Wolfgang published an article about the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0,SMILESS:C1=NC(=C(Cl)[N]1C)[N+]([O-])=O ).Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4897-25-0) through the article.

A synthesis of model 8-substituted 12-methyl-12H-imidazo[4′,5′:2,3][1,4]diazepino[6,7,1-jk]carbazoles I (R = Me, 4-tolyl, 2-thienyl), based on the classical Bischler-Napieralski method, is described. Thus interaction of carbazole with 5-chloro-1-methyl-4-nitro-1H-imidazole (in the presence of NaH) produced the corresponding 9-(1-methyl-4-nitro-1H-imidazol-5-yl)-9H-carbazole. Subsequent chem. reduction of the nitro group into the resp. amino derivative and acylation of the resulting amino group furnished the resp. amides. Cyclocondensation of the latter, using polyphosphoric acid under Bischler-Napieralski conditions, delivered the target compounds The structures of these new pentacyclic heterocycles were supported by IR, MS, and NMR.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Immunosuppression by 9-alkyl-6-thiopurines, published in 1972, which mentions a compound: 4897-25-0, mainly applied to immunosuppression thiopurine derivative; antibody formation inhibition thiopurine, Recommanded Product: 4897-25-0.

6-Mercaptopurine [50-44-2], 9-butyl-6-mercaptopurine [6165-01-1], azathioprine [446-86-6], 9-butylazathioprine [20917-47-9], 6-methylthioinosine [342-69-8], chloroimidazole [4897-25-0], 6-thioguanine [154-42-7], 9-butyl-6-thioguanine [30546-08-8], guaneran [5581-52-2], 9-butylguaneran [36892-45-2], 6-thioguanosine [85-31-4], and 6-methylthioguanosine [34020-33-2] significantly suppressed the antibody response of mice to sheep red blood cells. Only 5-glutathionyl-1-methyl-4-nitroimidazole [36892-55-4] and 9-isobutylguaneran [36892-43-0] had no significant effect. Thus, 2 classes of 6-thiopurines have immunosuppressive activity: 9-unsubstituted derivatives which form nucleotide analogs inside cells and stable 9-alkyl derivatives which have a mechanism of action unrelated to nucleotide formation.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about Electrochemical reduction of bifunctional organic compounds. XIII. N-methylnitroimidazole substitution in water-alcohol buffer media, the main research direction is polarog nitroimidazole pH cation effect; imidazole nitro polarog media effect.SDS of cas: 4897-25-0.

The polarog. reduction of I (R = H, Cl, Br, NO2; R1 = H, Br, NO2) was studied at pH 1.20-11.26 in the presence of different cations. Both the extent and mechanism of reduction depended on whether tetraalkylammonium or alkali metal cations were present.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.Category: chlorides-buliding-blocks. The article 《Determination of cysteine with 1-methyl-4-nitro-5-chloroimidazole》 in relation to this compound, is published in Chemia Analityczna (Warsaw, Poland). Let’s take a look at the latest research on this compound (cas:4897-25-0).

Cysteine was heated with 1-methyl-4-nitro-5-chloroimidazole in a pH 10 NH3 buffer for 1 h at 50° to form a 1:1 complex which had an absorption maximum at 410 nm. Beer’s law was obeyed for 10-5-10-3M cysteine.

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