Category: 4897-25-0

Category: nitriles-buliding-blocks. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro. Author is Widel, M.; Watras, J.; Suwinski, J.; Salwinska, E..

In vitro studies in V79-379A cells on the radiosensitizing efficiency, cytotoxicity, and reactivity with blood thiols of a series of chloronitroimidazoles (I where R1 = Me or H, R2 = Cl, H, or Me, R4 = NO2, H, Cl, NO2H, or NO2Cl, and R5 = H, Cl, NO2, NO2H, NO2Cl) are presented. The derivatives of 4-nitroimidazole substituted in the 5 position with Cl show higher radiosensitizing efficiency to γ-rays than one might expect from their reduction potential. At the same time they are extremely toxic, especially for aerobic cells. It is thought that the high biol. activity of ortho-substituted 4-nitroimidazoles is connected with their considerable chem. reactivity towards thiols and suppression of those natural protective compounds in the cells. The corresponding 5-nitro isomers are ∼10-fold weaker sensitizers, and simultaneously much less cytotoxic, either in aerobic or in hypoxic conditions. The chloro-4(5)-nitroimidazoles are unsubstituted at N-1 and ionizable in aqueous solution are relatively weaker but at the same time less toxic radiosensitizers. The potential application in radiotherapy is indicated for those chloronitroimidazoles which show low aerobic cytotoxicity, moderate radiosensitizing ability, and no reactivity towards thiols. On the basis of the in vitro study, 1-methyl-2-chloro-4-nitroimidazole (P13) has been selected for screening in vivo.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Stability-indicating assay for azathioprine and 6-mercaptopurine by reversed-phase high-performance liquid chromatography, published in 1979-12-30, which mentions a compound: 4897-25-0, Name is 5-Chloro-1-methyl-4-nitroimidazole, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

A rapid method based on reversed-phase high-performance liquid chromatog. is described for the separation and quantitation of azathioprine (I) [446-86-6], 6-mercaptopurine (II) [50-44-2] and their potential contaminants and degradants present in dosage forms. Procedures based on simple dissolution or extraction in 0.02 M NaOH give quant. precision of 1% relative standard deviation at the macro-level and 2% relative standard deviation for the microassay of analytes. The method is stability-indicating and was used for preliminary studies of the degradation of I in 0.9% NaCl injection, subjected to thermal or UV irradiation treatment. The content uniformity of dosage forms of I and II was measured. Only I injection as the freeze-dried Na salt [55774-33-9] contained detectable amounts of contaminants 1-methyl-4-nitro-5-chloroimidazole [4897-25-0] and hypoxanthine [68-94-0].

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Electric Literature of C4H4ClN3O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Research in the imidazole series. 96. Reaction of 1-methyl-4-nitro-5-chloroimidazole with phenols, naphthols, and 8-hydroxyquinoline. Author is Reznichenko, L. A.; Gireva, R. N.; Kochergin, P. M.; Aleksandrova, E. V..

By reactions of 1-methyl-4-nitro-5-chloroimidazole with 4-nitrophenol, α- and β-naphthols, and 8-hydroxyquinoline, a number of 1-methyl-4-nitro-5-[aryl(or heteroaryl)oxy]imidazoles have been obtained. With aminophenols under analogous conditions, 1-methyl-4-nitro-5-[(hydroxyphenyl)amino]imidazoles have been obtained.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Product Details of 4897-25-0.Yonehara, Ryo; Nada, Shigeyuki; Nakai, Tomokazu; Nakai, Masahiro; Kitamura, Ayaka; Ogawa, Akira; Nakatsumi, Hirokazu; Nakayama, Keiichi I.; Li, Songling; Standley, Daron M.; Yamashita, Eiki; Nakagawa, Atsushi; Okada, Masato published the article 《Structural basis for the assembly of the Ragulator-Rag GTPase complex》 about this compound( cas:4897-25-0 ) in Nature Communications. Keywords: Rag GTPase mTORC HBXIP protein structure lysosome. Let’s learn more about this compound (cas:4897-25-0).

The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions. The activity of mTORC1 is controlled by Rag GTPases, which are anchored to lysosomes via Ragulator, a pentameric protein complex consisting of membrane-anchored p18/LAMTOR1 and two roadblock heterodimers. Here we report the crystal structure of Ragulator in complex with the roadblock domains of RagA-C, which helps to elucidate the mol. basis for the regulation of Rag GTPases. In the structure, p18 wraps around the three pairs of roadblock heterodimers to tandemly assemble them onto lysosomes. Cellular and in vitro analyses further demonstrate that p18 is required for Ragulator-Rag GTPase assembly and amino acid-dependent activation of mTORC1. These results establish p18 as a critical organizing scaffold for the Ragulator-Rag GTPase complex, which may provide a platform for nutrient sensing on lysosomes.

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Product Details of 4897-25-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Highly selective solid phase extraction and preconcentration of Azathioprine with nano-sized imprinted polymer based on multivariate optimization and its trace determination in biological and pharmaceutical samples. Author is Davarani, Saied Saeed Hosseiny; Zad, Zeinab Rezayati; Taheri, Ali Reza; Rahmatian, Nasrin.

In this research, for first time selective separation and determination of Azathioprine is demonstrated using molecularly imprinted polymer as the solid-phase extraction adsorbent, measured by spectrophotometry at λmax 286 nm. The selective molecularly imprinted polymer was produced using Azathioprine and methacrylic acid as a template mol. and monomer, resp. A molecularly imprinted solid-phase extraction procedure was performed in column for the analyte from pharmaceutical and serum samples. The synthesized polymers were characterized by IR spectroscopy (IR), field emission SEM (FESEM). In order to investigate the effect of independent variables on the extraction efficiency, the response surface methodol. (RSM) based on Box-Behnken design (BBD) was employed. The anal. parameters such as precision, accuracy and linear working range were also determined in optimal exptl. conditions and the proposed method was applied to anal. of Azathioprine. The linear dynamic range and limits of detection were 2.5-0.01 and 0.008 mg L- 1 resp. The recoveries for analyte were higher than 95% and relative standard deviation values were found to be in the range of 0.83-4.15%. This method was successfully applied for the determination of Azathioprine in biol. and pharmaceutical samples.

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COA of Formula: C4H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Kinetic studies of the photodegradation of nitroimidazole derivatives in the solid state. Author is Marciniec, Barbara; Bugaj, A.; Kedziora, W..

The kinetics of the photodegradation of 7 nitroimidazoles including the chemotherapeutics metronidazole, ornidazole, and tinidazole were determined in the solid state by a direct method from the IR spectra using the “”alkali-halide matrix”” technique. The photochem. decomposition of nitroimidazole in the solid state proceeds according to a first-order reaction. An order of photochem. stability of nitromidazole derivatives in the solid state. is suggested using the calculated kinetic parameters. The photochem. stability of the studied compounds is affected by the substituents at position N(1) and C(5) of the nitroimidazole ring.

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Formula: C4H4ClN3O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Metabolic fate of the methylnitroimidazole moiety of azathioprine in the rat. Author is De Miranda, Paulo; Beacham, Lowrie M. III; Creagh, Teresa H.; Elion, Gertrude B..

The major unbound radioactive metabolite of 14C-labeled azathioprine (I) [446-86-6], labeled on the methylnitroamidazole ring, in rat liver homogenates, was 1-methyl-4-nitro-5-(S-glutathionyl)imidazole [36892-55-4] while .sim.10% of the radioactivity was bound to protein. The major urinary metabolite was 1-methyl-4-nitro-5-(N-acetyl-S-cysteinyl)imidazole [51052-82-5], which was a biotransformation product of the glutathionyl imidazole. The metabolite was also isolated from rat liver perfusates by incubation of I with blood and in vivo in the blood, but not in the urine, of rats given I. The various modes of splitting of I and of the formation of 1-methyl-4-nitro-5-thiomidazole [6339-54-4] are discussed and a pathway for the metabolic alteration of I into its principal methylnitroimidazole metabolites in the rat was proposed.

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Related Products of 4897-25-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about The kinetics of the reaction of ‘anomalous’ 4-nitroimidazole radiosensitizers with thiols. Author is Wardman, P..

Kinetic data for the nonenzymic conjugation of GSH  [70-18-8] and dithiothreitol  [3483-12-3] with the radiosensitizers, 5-chloro-1-methyl-4-nitroimidazole  [4897-25-0] and Ro 31-0750  [13755-79-8], provided upper limits for the half-lives of these compounds when administered in vivo, and suggest that thiol depletion by such compounds in vitro is probably accelerated by glutathione S-transferases. The substantial enhancement of radiosensitization caused by nonprotein thiol depletion may be restricted to dilute cell suspensions in vitro since depletion of a significant proportion of nonprotein thiol in vivo seems unlikely at realistic dose regimes in man.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Identification and determination of azathioprine in the presence of 6-mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole, the main research direction is azathioprine spectrometry determination; mercaptopurine azathioprine determination; chloromethylnitroimidazole azathioprine determination; clomizole azathioprine determination.Formula: C4H4ClN3O2.

Azathioprine (I) [446-86-6] was separated from the other title compounds (substrates in I synthesis) by paper chromatog. with 4:1:1, BuOH-EtOH-H2O, 3:1 PrOH-N AcOH or 3:1 PrOH-0.2N aqueous NH3, the 1st 2 systems also being effective in thin-layer chromatog. on silica gel. Reduction of I with Zn in 5% aqueous NH3 saturated with NH4Cl gave a purple-red product. This color reaction was used for determining I in the title mixtures and in pharmaceutical preparations by photometry at 525 nm.

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Synthetic Route of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Mechanism of formation of 5-mercapto-1-methyl-4-nitroimidazole, a metabolite of the immunosuppressive drug azathioprine. Author is Chalmers, A. H..

Studies of the urine of mice and dogs after administration of azathioprine (I) [446-86-6] or 3 derivatives indicated that 5- mercapto-1-methyl-4-nitroimidazole (II) [6339-54-4] is formed from the glutathione-imidazole adduct,5-glutathionyl-1-methyl-4- nitroimidazole [36892-55-4]. Oral and i.v. administration of I to patients and dogs suggested that I is probably absorbed per se from the gut.

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