Category: 4897-25-0

Safety of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?. Author is Clarke, Eric D.; Wardman, Peter.

Reduction of 5-chloro-1-methyl-2-nitroimidazole (I) using HCO2-/N2O reducing system was characterized, and calculations at 450 nm and pH 2.2-8.3 gave a pKa of 3.3 for the prototropic equilibrium Experiments on the rate of oxidation of I radical by Fe(CN)63- demonstrated that reduction of I by the Me2CHOH/N2O system gave a radical with unit neg. charge at pH 8.2 which was oxidized by Fe(CN)63-. At 410 nm, the I radical produced in the HCO2- system was extremely long-lived at pH >7; the rate of decay increased progressively as pH was lowered and second order rate constants for radical-radical reaction were estimated γ-Radiolysis of N2O-saturated solutions containing I and HCO2- (concentration ratio of HCO2- to I ≃100) at pH 7.4 and 310 nm and Na2S2O4 anaerobic reduction of I indicated that dissociative electron attachment occurs, producing Cl- with high efficiency. The radical produced initially upon reaction of I with simple one-electron reducing agents behaves as a normal nitroimidazole radical-anion on the timescale of pulse radiolysis measurements. If the radical-anion of I dissociates to yield Cl- and a neutral radical, it does so only at times >1 s at pH 7, i.e. possibly accompanying the disproportionation or other reaction of 2 radicals.

《Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Safety of 5-Chloro-1-methyl-4-nitroimidazole.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Poloniae Pharmaceutica called Kinetic studies of photodegradation of nitroimidazole derivatives in solutions, Author is Marciniec, Barbara; Bugaj, Andrezej, which mentions a compound: 4897-25-0, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

Kinetics of the photodegradation of metronidazole, ornidazole, and tinidazole as well as of 1-methyl-4-nitro-5-chloro-, 1-methyl-4-nitro-5-hydroxy-, 1-methyl-4-nitro-5-mercapto-, and 2-methyl-5-nitroimidazole was studied in aqueous solutions The process was a 1st temporal order reaction with a complex mechanism. A linear dependence was found between the t0.5 values and the squared reciprocal of electron d. Photochem. stability of the investigated nitroimidazoles depended on electrophilicity of the substituent on C(5).

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Quality Control of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Author is Jolanki, Riitta; Alanko, Kristiina; Pfaffli, Pirkko; Estlander, Tuula; Kanerva, Lasse.

A 46-yr old man, working on azathioprine synthesis, developed a rash on the face, especially the eyelids, neck, and hands, after minimal exposure to the drug intermediate, AZA III, in powder form, when he weighed the chem. in small amounts without using protective gloves. This contact allergy to 5-chloro-1-methyl-4-nitroimidazole, an intermediate product of azathioprine, had not been previously reported. This compound was shown to be present in the end products, azathioprine and azathioprine tablets, in amounts sufficient to induce allergic patch test reactions in a sensitized patient. Cross-reactivity was found between 5-chloro-1-methyl-4-nitroimidazole and 3 of 6 imidazole derivatives used as antifungal drugs tested.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.Recommanded Product: 117918-23-7. The article 《Occupational contact dermatitis: New allergens》 in relation to this compound, is published in Dermatology at the Millennium, The Proceedings of the World Congress of Dermatology, 19th, Sydney, Australia, June 15-20, 1997. Let’s take a look at the latest research on this compound (cas:4897-25-0).

A review with 9 references concerning allergens and products recently discussed by the authors (5-chloro-1-methyl-4-nitroimidazole, 3-dimethylaminopropylamine, fungal α-amylase, chloramine-T solution, and tri-cure glass ionomer) which cause allergic contact urticaria and allergic contact dermatitis upon exposure is given.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Use of chemicals for the preservation of polychromed wood, published in 1988-01-31, which mentions a compound: 4897-25-0, mainly applied to polychrome wood preservation chem, SDS of cas: 4897-25-0.

Polychromed wood was examined and pigments used were applied to Picea excelsa blocks on bases used for making original art objects. The samples were impregnated with Antox W (p-coumylophenol + methoxychlor), Xyligen Al (I), Vitavax, or PCMNI (II) and effects on dominant wavelength, colorimetric purity, and the degree of clarity were determined I caused the least darkening of the pigments.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Material und Organismen called Toxicity of imidazole derivatives to selected fungi of the classes Ascomycetes and Deuteromycetes, Author is Gajdzinski, Maciej; Mroczkiewicz, Andrzej, which mentions a compound: 4897-25-0, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2, Reference of 5-Chloro-1-methyl-4-nitroimidazole.

The lowest concentrations of imidazole derivatives that showed fungicidal effects on 5 selected mold fungi (Ascomycetes and fungi imperfecti) were determined by the agar plate method. Those imidazole derivatives that had halo and a NO2 group on the ring were the most toxic towards these fungi. 5-Chloro-1-methyl-4-nitroimidazole  [4897-25-0] was particularly toxic; quantities of 600-1000 ppm added to the nutrient agar completely inhibited growth.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.COA of Formula: C4H4ClN3O2.Pan, Fuyou; Liang, Huading published the article 《Reversed-phase high-performance liquid chromatographic determination of azathioprine and its intermediates》 about this compound( cas:4897-25-0 ) in Fenxi Huaxue. Keywords: azathioprine determination reversed phase HPLC; liquid chromatog determination azathioprine. Let’s learn more about this compound (cas:4897-25-0).

The RP-HPLC determination of Azathioprine and its intermediates (mercaptoprine, 1-methyl-4-nitro-5-chloro imidazole) capsules by using shim-pack CLC_ODS(5μm, 4.6 mm I.D. × 150 mm) column, acetonitrile-water(30:70 V/V) as mobile phase flow rater, 0.8 mL/min and UV 210 nm detector. Good linearity was obtained in the concentration range of 0.05 – 15 mg/L with standard calibration curve of Azathioprine y = 109821x – 2450,r = 0.9999, Mercaptoprine y = 68173x + 2034,r = 0.9998, 1-methyl-4-nitro-5-chlorine-imidazole y = 64438x – 1353,r = 0.9995. The method has been used to determine drug samples with satisfactory results.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis.Synthetic Route of C4H4ClN3O2.

We isolated a new illegal sildenafil analog named mutaprodenafil (I) from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.

After consulting a lot of data, we found that this compound(4897-25-0)Synthetic Route of C4H4ClN3O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called HPLC determination of the related substances in Azathioprine Tablets, published in 2013-02-28, which mentions a compound: 4897-25-0, Name is 5-Chloro-1-methyl-4-nitroimidazole, Molecular C4H4ClN3O2, COA of Formula: C4H4ClN3O2.

A HPLC method for determination of related substances in Azathioprine Tablets was established. The C18 column (200 mm×4.6 mm, 5 μm) was used. The mobile phase consisted of methanol and 0.05% of sodium acetate solution (18:82) at the flow rate of 1.2 mL·min-1, and the detection wavelength was set at 300 nm. The linear ranges of the two typical related substances mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole in Azathioprine Tablets were all 0.125-1.80μg·mL-1 (r=0.9997 and 0.9999) with the detection limits of 0.787 ng and 0.933 ng, and the average recoveries were 100.3% and 100.0% with the RSD of 0.64% and 0.14%. The method proposed for determining the related substances of Azathioprine Tablets is simple, quick and the result is accurate and specific.

After consulting a lot of data, we found that this compound(4897-25-0)COA of Formula: C4H4ClN3O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

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Nitrile – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Huaxue Yanjiu Yu Yingyong called A new synthetic technique of 5-chloro-1-methyl-4-nitroimidazole, Author is Liu, Cong; Yan, Xiaofei; Ren, Yingge; Shen, Ning; Liu, Qianfeng, the main research direction is chloro methyl nitroimidazole preparation Azathioprine intermediate.Safety of 5-Chloro-1-methyl-4-nitroimidazole.

A method for the preparation of 5-chloro-1-methyl-4-nitroimidazole was developed with di-Et oxalate, aqueous methylamine formate, phosphorus pentachloride, mixed acid etc as starting materials. The synthesis of the target compound was achieved (64% yield) by a sequence involving an aminolysis reaction, condensation and nitration reaction. The process provided an energy-saving high yield synthetic method (green chem.) and the product thus obtained was confirmed by MS, NMR, FT-IR. The title compound is an intermediate for 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine [Azathioprine, Imuran, immunosuppressant].

After consulting a lot of data, we found that this compound(4897-25-0)Safety of 5-Chloro-1-methyl-4-nitroimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts