Category: 4897-25-0

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine, the main research direction is azathioprine optimized preparation; chloroimidazole reaction mercaptopurine; imidazole chloro reaction mercaptopurine; purine mercapto reaction chloroimidazole.Category: nitriles-buliding-blocks.

The reaction conditions for the synthesis of azathioprine (I) were optimized with the help of UV spectroscopy. Thus, 0.029 mol imidazole II in 25 cm3 DMF was stirred into 0.029 mol 6-mercaptopurine hydrate in 15 cm3 DMF, 20 cm2 THF, and 40 cm3 25% aqueous NH4OH and the mixture heated to 70-90° 1.5 h to give 95% crude azathioprine, purified to give 80% product.

This compound(5-Chloro-1-methyl-4-nitroimidazole)Category: nitriles-buliding-blocks was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C4H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Some examples of anomalous radiosensitizing behavior of electron-affinic compounds in vitro. Author is Watts, M. E.; Jacobs, R. S..

The radiosensitizing activities of several nitroheterocyclic compounds for x-irradiated cells differ from the general patterns repeated for a number of nitroarom. and nitroheterocyclic compounds (sensitizing efficiency related to electron affinity, dose dependence of affect, and radiosensitization of hypoxic but not oxygentated cells). CMNI (I) [4897-25-0] was a much more potent radiosensitizer than predicted from its redox potential, L 6993 (II) [23571-52-0] extended a fairly constant effect over the concentration range 10-6-10-2M, and furaspor (III) [586-84-5] radiosensitized both hypoxic and oxygenated cells. Possible mechanisms for these anomalous effects are discussed.

This compound(5-Chloro-1-methyl-4-nitroimidazole)COA of Formula: C4H4ClN3O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.Carvalho, Alcione S.; Ferreira, Edmir F.; Soares, Renata O. A.; Souza, Adriano S.; Pinto, Angelo C.; Bozza, Marcelo; Boechat, Nubia published the article 《Synthesis of azoles distinguishing a trifluoromethyl derivative with potent dual anti-Trypanosoma cruzi activity and cell growth inhibitions》 about this compound( cas:4897-25-0 ) in Fluorinated Bioactive Compounds in the Agricultural & Medical Fields, Proceedings of the Conference, Brussels, Sept. 13-15, 1999. Keywords: conference trifluoromethyl azole preparation trypanosomicide; nitroimidazolyl trifluoromethyl triazolamine preparation trypanosomicide; proliferation inhibitor methylnitropyrazolylimidazole methylnitroimidazolyl triazolamine preparation; nitro pyrazolyl imidazole preparation trypanosomicide. Let’s learn more about this compound (cas:4897-25-0).

A conference report. The synthesis of N-(1-methyl-4-nitro-1H-imidazol-5-yl)-5-(trifluoromethyl)-1H-1,2,4-triazol-3-amine and 1-methyl-4-nitro-5-(1H-pyrazol-1-yl)-1H-imidazole and their trypanosomicidal activity were reported.

This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.COA of Formula: C21H16N2. The article 《A validated UPLC method for the determination of process-related impurities in Azathioprine bulk drug》 in relation to this compound, is published in Analytical Methods. Let’s take a look at the latest research on this compound (cas:4897-25-0).

An UPLC method was developed and subsequently validated for the determination of Azathioprine and its process-related impurities. Separation was achieved with Acquity UPLC BEH C18, 100 × 2.1 mm, 1.7 μm column and trifluoroacetic acid (0.05% in water): acetonitrile as eluent in gradient mode. Flow rate was set at 0.35 mL min-1. UV detection was performed at 220 nm. The method was validated with respect to specificity, accuracy, precision, linearity, robustness, limit of quantification, and limit of detection. The accuracy of the method demonstrated at 3 levels in the range of 50-150% of the specification limit and the recovery of impurities were found to be in the range of 98 to 102%. The detection limits of the process related impurities ranged between 0.16 and 0.24 μg mL-1. The described method is simple, rapid, linear, precise, and robust. The method is useful during process development and quality control of bulk manufacturing

This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 5-Chloro-1-methyl-4-nitroimidazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation. Author is Suwinski, Jerzy; Salwinska, Ewa; Watras, Jan; Widel, Maria.

5(4)-Chloro- and 2-chloro-4(5)-nitroimidazole or their N-Me derivatives were prepared by ≥2 independent routes. Contrary to some former reports, only 2-chloro-4-(or 5)-nitroimidazoles were obtained from 2,4(or 5)-dinitroimidazoles. In 4,5-dinitroimidazoles only a nitro group in the 5 position was replaced by a chlorine atom.

《Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Name: 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 5-Chloro-1-methyl-4-nitroimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Determination of two related substances in azathioprine tablets by HPLC.

An HPLC method was developed to determine 6-mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole, which were related substances of azathioprine tablets. An ODS C18 column (250 mm × 4.6 mm, 5 μm) was used with the mobile phase of a mixture of sodium heptanesulfonate solution (sodium heptanesulfonate 1.336 g, dissolved in 850 mL water)-methanol (85:15, adjust the solution with 1 mol/L-1 hydrochloric acid to a pH of 3.5) at a flow rate of 1.0 mL/min-1. The detection wavelength was at 254 nm. For 6-mercaptopurine, the calibration curve was linear in the range of 4. 68 ± 10-4 to 0.014 mg/mL-1 with correlation coefficient 0.9997 and the regression equation being Y = 5400X-0.5302. The average recovery (n = 9) was 99.5%, and the detection limit was 1 ng . For 5-chloro-1-methyl-4-nitroimidazole, the calibration curve was also linear in the range of 5. 51 ± 10-4 to 0.0165 mg/mL-1 with correlation coefficient 0.9994 and the regression equation being Y = 6743X-1.396, the average recovery (n = 9) was 99.7%, and the detection limit was 2.5 ng. Sample solution and standard solution are all stable within 8 h. This method is specific, accurate, sensitive, and simple.

《Determination of two related substances in azathioprine tablets by HPLC》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Reference of 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Recommanded Product: 4897-25-0.Singin, A. S.; Ovchinnikova, V. A.; Savin, Yu. I.; Safonova, T. S. published the article 《Synthesis of labeled sulfur-containing antitumorigenic preparations and study of their metabolism in the body》 about this compound( cas:4897-25-0 ) in Tezisy Dokl. Nauchn. Sess. Khim. Tekhnol. Org. Soedin. Sery Sernistykh Neftei, 14th. Keywords: purine imidazolylthio labeled; piperazine thiophosphoryl labeled; metabolism labeled sulfur. Let’s learn more about this compound (cas:4897-25-0).

Piperazine derivatives I and II were prepared in 70% yields by treatment of piperazine with 32PSCl3 or P35SCl3 followed by treatment with ethylenimine. Treatment of 6-hydroxypurine III (R = OH) with P235S5 gave III (R = 35SH) which was reacted with chloromethylnitroimidazole to give IV. The labeled compounds were useful in studying the mechanism of human metabolism

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Recommanded Product: 4897-25-0 require different conditions, so the reaction conditions are very important.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Chemistry of the phenoxathiins and isosterically related heterocycles. XXIX. The crystal and molecular structure of 5-(3-hydroxy-2-pyridylthio)-4-nitro-1-methylimidazole, the main research direction is crystal structure pyridylthioimidazole preparation; mol structure pyridylthioimidazole preparation; imidazole pyridylthio preparation crystal structure.Product Details of 4897-25-0.

Reaction of the dianion of 3-hydroxypyridine-2(1H)-thione with 5-chloro-4-nitro-1-methylimidazole led to the formation of 5-(3-hydroxy-2-pyridylthio)-4-nitro-1-methylimidazole (I), which did not cyclize to the desired pyrid[1,4]oxathiinoimidazole derivative In an effort to determine why I did not cyclize, its crystal structure was determined Both the conformation of I and electronic factors could be responsible for its non-cyclization.

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Product Details of 4897-25-0 require different conditions, so the reaction conditions are very important.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Synthesis of 1-methyl-4-nitro-5-substituted imidazole and substituted imidazolothiazole derivatives as possible antiparasitic agents. Author is Mukherjee, Anita; Kumar, Shiv; Seth, M.; Bhaduri, A. P..

Reactions of 5-chloro-1-methyl-4-nitroimidazole (I) with appropriate nucleophiles gave the desired 5-substituted imidazole derivatives Oxidation of I with CrO3 in AcOH furnished 1-methylimidazoline-2,4,5-trione. These compounds and 2 substituted imidazolothiazole derivatives were evaluated for their antileishmanial, antiamebic, and anthelmintic activities. None of the compounds exhibited any noteworthy activity for drug developmental work.

Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)COA of Formula: C4H4ClN3O2 require different conditions, so the reaction conditions are very important.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Helvetica Chimica Acta called Synthesis of heteroxanthine from a derivative of imidazole, Author is Sarasin, J.; Wegmann, E., which mentions a compound: 4897-25-0, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

S. and W. describe a new synthesis of 7-methylxanthine from an imidazole derivative, by closing the pyrimidine ring, an operation which has not been previously effected. 1-Methyl-4-nitro-5-chloroimidazole (I) is obtained in theoretical yield from 1-methyl-5-chloroimidazole (b. 200°) (II) by dissolving in dilute HNO3 to form the nitrate, treating the latter with cold concentrated H2SO4, heating the mixture on the water bath for 2 hrs., and pouring the product on ice; it m. 147-8°, and is insoluble in acids and dilute alkalies. The isomeric 1-methyl-5-nitro-4-chloroimidazole (III), obtained by the same method from 1-methyl-4-chloroimidazole; m. 77-8°. I and III are reduced at 0° by Sn and HCl to the corresponding methylchloroaminoimidazoles which were not obtained in the pure state. I heated for several hrs. on the H2O bath in EtOH with 2 mols. KCN and 0.1 mol. KI yields 85% 1-methyl-4-nitro-5-cyanoimidazole (IV), m. 141-2°, insoluble in acids and dilute alkalies. 1-Methyl-4-nitroimidazole-5-carboxamide (V), obtained in 90% yield when IV is heated for 2 hrs. on the H2O bath with 8 times its weight of concentrated H2SO4 and the product is poured on ice, m. 257-8° (decomposes), insoluble in acids and alkalies, saponified with great difficulty; a small amount of the acid (VI) is obtained by prolonged action of concentrated HCl. VI m. 160° with evolution of CO2 and formation of 1-methyl-4-nitroimidazole (VII), m. 133-40°, which is also obtained by heating V in a sealed tube at 120° with HCl. Reduction of VII by Sn and HCl at 0° and hydrolysis of the product by heating under pressure with HCl, gives NH4Cl and sarcosine-HCl, m. 168-9°; this reaction establishes the constitution of II and VII. V is reduced at 0° by Sn and HCl to the corresponding amine, 1-methyl-4-aminoimidazole-5-carboxamide (VIII), m. 184-5°, decomposed when heated with water or dilute alkalies with evolution of NH3; HCl salt, m. 214-5°. 7-Methylxanthine (heteroxanthine) obtained in 38% yield by heating 0.4 g. of VIII for 8 hrs. in a sealed tube at 160-70° with an equal weight of CO(OEt)2, m. 380° (browning and evolution of gas). A mixture of the substance with heteroxanthine prepared from theobromine melts at the same temperature The murexide reaction is given with KClO3 and HCl.

《Synthesis of heteroxanthine from a derivative of imidazole》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Recommanded Product: 4897-25-0.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts