Category: 4640-67-9

Reference of 4640-67-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 0.11 g (0.67 mmol) 3 -(4-fluoro -phenyl)- 3-oxo-propionitrile in 4 ml ethanol was added 0.06 ml (0.67 mmol) cyclopentanone, 22 mg (0.67 mmol) sulfur, and 0.06 ml (0.67 mmol) morpholine. The mixture was heated at 60 0C for 2 h, and then poured onto water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. Trituration in ether afforded 0.17 g (98%) (2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-fluoro- phenyl)-methanone as a red solid. ES-MS m/e (%): 262 (M+H+, 100).

The synthetic route of 3-(4-Fluorophenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63732; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4640-67-9, Computed Properties of C9H6FNO

General procedure: 1H-Pyrazol-5-amine 1 (1 equiv.), 3-oxopropanenitrile 2 (1 equiv.), benzaldehyde 3 (1 equiv.), and Et3N (2 equiv.) were stirred in DMF (1 M) at 90 C for 16 h. The volatiles were removed under reduced pressure (or positive N2 (g) pressure). Sodium nitrite (3 equiv.) and acetic acid (134 equiv.) were added to the crude material, and the reaction mixture was stirred for 10 min. The volatiles were removed under reduced pressure (or positive N2 (g) pressure), and the crude reaction mixture was subjected to silica gel column chromatography with ethyl acetate in hexanes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Fluorophenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hill, Matthew D.; Synthesis; vol. 48; 14; (2016); p. 2201 – 2204;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 4640-67-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The polyphosphoric acid 300g adding 1L the reaction bottle heating to 120 C, adding compound 3 (100g, 0.61 muM), ring octanone (161.7g, 1 . 28 muM), add 1 – ethyl -3 – methyl imidazole four fluoroborates (30g, 0.15 muM) reaction 1h, after the reaction, by adding 300 ml ice water, 1000 ml ethyl acetate, stirring 30min, then adding NaOH in and to the neutral, separating the organic layer, the organic layer dried with magnesium sulfate, filtered, the filtrate is concentrated to dry, adding isopropanol (300 ml) reflux 30min stirred and cooled to 0 C after, stirring 1h, filtered and dried to obtain white solid 4 (120g, 99.8%),

The synthetic route of 3-(4-Fluorophenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Yuan Shu Pharmaceutical Technology Co., Ltd; Jin, Guofan; Jin, Feng; Wang, Kai; Zheng, Bing; Fu, Yan; Jin, Zaishan; Liu, Jiongzhe; (6 pag.)CN106045909; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H6FNO

400 g of phosphorus pentoxide 4000 g of mesyl acid Followed by stirring at 50 C for 3 hours. After cooling to 20-25 C, 118.5 g of cyclooctanone of Formula 2 and 153.3 g of 3-(4-fluorophenyl)-3-oxopropanenitrile of Formula 3 were added and stirred at 50 C for 12 hours. The reaction mixture was extracted with water and dichloromethane, and the organic layer was washed with brine, followed by adding anhydrous sodium sulfate and activated charcoal, followed by filtration and distillation. Recrystallization from ethyl acetate and hexane gave 95% yield 4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2 (1H)-one

The synthetic route of 3-(4-Fluorophenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kukjeon pharmaceutical.Co.,Ltd.; Hong, Jong Ho; Jo, Ir Hwan; Kim, Sung Han; Moon, Jong Taek; Kim, Eun Jung; Kim, Jae Young; (5 pag.)KR2016/49217; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4640-67-9, Computed Properties of C9H6FNO

To a solution of 3-(4-fluorophenyl)-3-oxopropanenitrile (1 g, 6.13 mmol) in ethanol (11 mL) was added hydrazine hydrate (1.82 mL, 36.8 mmol). The reaction mixture was stirred at 100C in a sealed vessel for 6 h. The solvents were evaporated in vacuo and the residue was extracted with EtOAc and brine. The organic solvents were dried over magnesium sulphate and evaporated in vacuo. The residue (1.18 g) was dissolved in EtOAc (anhydrous), then the procedure for Intermediate 1 was applied. The title compound (914 mg, 57%) was isolated as a white powder. C NMR delta (DMSO-d6, 75 MHz) 173.19, 163.01 (d, JCF 245.0 Hz), 154.61, 141.81, 141.59, 128.63 (2C, d, JCF 8.4 Hz), 127.97, 115.94 (2C, d, JCF 21.6 Hz), 86.88. MS (m/z) 263 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Fluorophenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HORSLEY Helen Tracey; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193169; A1; (2015);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

4640-67-9, Name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, 4640-67-9, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

According to the method described in Embodiment 1,Add 1f (0.5 mmol, 82 mg), 2a (1.25 mmol, 173 mg) to a 15 mL pressure tube. Dichloro(pentamethylcyclopentadienyl)rhodium(III)dimer (0.025 mmol, 15 mg), copper acetate monohydrate (1 mmol, 200 mg), cesium acetate (0.25 mmol, 48 mg) and 1,2-Dichloroethane (2 mL) was sealed under an air atmosphere, and then placed in an oil bath at 80 C for 14 h. The reaction was quenched with 10mL of water was added, extracted with ethyl acetate (10mL ¡Á 3),The organic phase was washed successively with water and saturated brine and dried over anhydrous sodium sulfate. Filtration, rotary evaporation, over silica gel (petroleum ether/ethyl acetate = 5/1) to give a yellow solid column 3fa (141mg, 81%).

Statistics shows that 3-(4-Fluorophenyl)-3-oxopropanenitrile is playing an increasingly important role. we look forward to future research findings about 4640-67-9.

Reference:
Patent; Henan Normal University; Fan Xuesen; Guo Chenhao; Zhang Beibei; Zhang Xinying; Li Bin; (17 pag.)CN108997298; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., 4640-67-9

To a mixtureof 4-fluorobenzoylacetonitrile (100 g), methane sulfonic acid(230.6 g) and water (14 mL) was heated to 65-70 C, stirredfor 3 h and added a cyclooctanone (85 g) at same temperaturethen heated to 110 to 115 C stirred for 2 h, cool to room temperaturethen diluted with dichloromethane and water, organiclayer was separated and washed organic layer with water, thendistilled under vacuum solid obtained and purified with acetoneto get pure compound. Yield: 120 g; 73 %.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sudarshan Rao; Nageswara Rao; Uma Sankara Sastry; Muralikrishna; Jayashree; Asian Journal of Chemistry; vol. 26; 18; (2014); p. 5928 – 5930;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4640-67-9

In a 25 mL reaction tube with a Teflon magnetic stir bar,Add 0.5 mmol of 4-fluorobenzoylacetonitrile, 0.5 mmol of 3-bromo-1,1,1-trifluoroacetone, 0.5 mmol of sodium acetate,Finally, 58 mmol of 1,4-dioxane was added, and the reaction was stirred at room temperature for 8 hours.Add 15 mL of water, extract three times with 10 mL of ether, and combine the organic phases.Washing with saturated sodium chloride solution, drying over anhydrous magnesium sulfate, and then removing the organic solvent by rotary evaporation;The obtained crude product was eluted with n-pentane and ethyl acetate (10:1, v/v).2-(4-Fluorophenyl)-5-hydroxy-5-(trifluoromethyl)-4,5-dihydrofuran-3-carbonitrile was isolated by silica gel column chromatography (yield: 76%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4640-67-9, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fuzhou University; Weng Zhiqiang; Wang Junwen; (29 pag.)CN110272400; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

4640-67-9, These common heterocyclic compound, 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2 (0.49 g, 1.7 mmol) in ethanol (20 ml) and piperidine (0.5 ml) as a catalyst was added substituted beta-ketonitriles 3a-d (1.7 mmol). The reaction mixture was heated under reflux for (8-10) h and the progress of the reaction was monitored by TLC using benzene/acetone (2:1) as eluent. The solvent was evaporated under reduced pressure; the oil residue was treated with petroleum ether 40-60C (3 x 10 ml) and recrystallized from ethanol to give (4a-d).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4640-67-9.

Reference:
Article; El-Borai, Mohamed A.; Rizk, Hala F.; Beltagy, Doha M.; El-Deeb, Ibrahim Y.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 415 – 422;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts