Category: 4556-23-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4556-23-4, is researched, Molecular C5H5NS, about Detection of Metal-Molecule-Metal Junction Formation by Surface Enhanced Raman Spectroscopy, the main research direction is metal junction SERS Raman spectroscopy.Recommanded Product: 4556-23-4.

Vibrational modes play a key role in characterizing metal-mol.-metal junctions, but their detection currently either requires single-mol. sensitivity or the generation of defect-free large-scale junctions. Surface-enhanced Raman scattering (SERS) on nonideal surfaces can provide a significant amount of information despite many defects in the layer. The authors determine the vibrational signature of the mol. electronic junction for palladium ions complexed and reduced on 4-mercaptopyridine adsorbed on rough gold and gold nanoparticles using SERS and d. functional theory. These nonideal surfaces can be used to probe kinetics of metal ion complexation and establish the success of electrochem. metalization. SERS on nonideal surfaces is thus revealed as a useful tool to rapidly establish the key process parameters in making mol. electronic junctions before embarking on more detailed studies on single mols. or single crystal surfaces.

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Computed Properties of C5H5NS. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Iridium-Catalyzed Propenylation Reactions for the Synthesis of 4-Pyridone Derivatives. Author is Bai, Xue-dan; Wang, Jie; He, Ying.

Herein we report an iridium-catalyzed propenylation reaction of allylic carbonates with 4-hydroxypyridine derivatives The process efficiently provides 4-pyridone derivatives with high stereoselectivities under mild conditions. The products could constitute valuable building blocks for the synthesis of natural products and other bioactive mols. Preliminary mechanistic studies indicated that a tandem allylic substitution/isomerization reaction occurs to afford the propenylation products.

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Song, Lijuan; Li, Wenhao; Duan, Wenxue; An, Jichao; Tang, Shanyu; Li, Longjia; Yang, Guanyu published the article 《Natural gallic acid catalyzed aerobic oxidative coupling with the assistance of MnCO3 for synthesis of disulfanes in water》. Keywords: disulfane preparation; thiol oxidative coupling gallic acid organocatalyst.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Category: nitriles-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.

To pursue a sustainable approach for such a synthesis, an aerobic oxidative coupling method for the efficient preparation of organic disulfanes RSSR1 [R = 4-MeC6H4, cyclohexyl, 2-thienyl, etc.; R1 = t-Bu, 4-ClC6H4, 4-H2NC6H4, etc.], using a low-toxic natural gallic acid as an organocatalyst, inexpensive MnCO3 as a cocatalyst, O2 as the terminal oxidant and water as the solvent, was successfully developed. Such metal-organic cooperative catalytic protocol provided an access to various sym. and unsym. disulfanes in up to 99% yield. Gram scale synthesis with practical convenience and low loading of catalysts further illustrated the practicability of our method.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Infused self-assembly on Langmuir-Blodgett Film: Fabrication of highly efficient SERS active substrates with controlled plasmonic aggregates, published in 2019, which mentions a compound: 4556-23-4, mainly applied to plasmonic aggregation Langmuir Blodgett film SERS fabrication, Recommanded Product: Pyridine-4-thiol.

A facile procedure towards the fabrication of highly reproducible, large area surface-enhanced Raman scattering (SERS) active substrates through integration of Langmuir-Blodgett and self-assembly technique has been reported. The plasmonic architectures of the substrates can be tuned at will to control the hot spots and hence the overall enhancements of SERS signal. The as-prepared substrates of classes “”A”” and “”B”” incubated in gold nanocolloids show their resp. efficacies as efficient SERS sensing scaffolds for detecting 4-MPy mol. at ultrasensitive concentrations Moreover, these substrates are unique in their kinds, where explicit or concomitant presence of protonated and deprotonated forms of 4-MPy can be detected at trace concentrations The substrates also exhibit remarkable spectral reproducibility and show early promise to overcome the “”SERS uncertainty principle””. To our knowledge, this genre of SERS active substrates with facile control over plasmonics, is the first report of its kind and are expected to provide new direction towards successful fabrication of the next generation SERS sensing platforms.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Crystal Field Effects on Atomic and Functional-Group Distributed Polarizabilities of Molecular Materials, published in 2020-12-03, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

To rationally design new mol. materials with desirable linear optical properties, such as refractive index or birefringence, we investigated how at. and functional-group polarizability tensors of prototypical mols. respond to crystal field effects. By building finite aggregates of urea, succinic acid, p-nitroaniline, 4-mercaptopyridine, or methylbenzoate, and by partitioning the cluster electronic d. using quantum theory of atoms in mols., we could extract atoms and functional groups from the aggregates and estimate their polarizability enhancements with respect to values calculated for mols. in isolation. The isotropic polarizability and its anisotropy for the mol. building blocks are used to understand the functional-group sources of optical properties in these model systems, which could help the synthetic chemist to fabricate efficient materials. This anal. is complemented by benchmarking d. functionals for at. distributed polarizabilities in gas phase, by comparing the results with refractive-index calculations under periodic boundary conditions, and by estimating functional-group optical properties from a classical electrostatic atom-dipole interaction model.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Analytical Chemistry (Washington, DC, United States) called Surface-Enhanced Raman Spectroscopy-Scanning Electrochemical Microscopy: Observation of Real-Time Surface pH Perturbations, Author is Hatfield, Kendrich O.; Gole, Matthew T.; Schorr, Noah B.; Murphy, Catherine J.; Rodriguez-Lopez, Joaquin, which mentions a compound: 4556-23-4, SMILESS is SC1=CC=NC=C1, Molecular C5H5NS, Formula: C5H5NS.

Understanding and controlling chem. dynamics at electrode interfaces is key to electrochem. applications in sensing, electrocatalysis, and energy storage. Here, we introduce colocalized surface-enhanced Raman scattering-scanning electrochem. microscopy (SERS-SECM) as a multimodal tool able to simultaneously probe and affect electrochem. interfaces in real time. As a model system to demonstrate SERS-SECM, we used a self-assembled monolayer of 4-mercaptopyridine (4MPy), a pH sensitive Raman indicator, anchored to silver nanoparticles as a substrate. We modulated the local pH at the surface with chronoamperometry, inducing the hydrogen evolution reaction (HER) at the SECM tip and observed subsequent Raman peak height changes in the 4MPy. We then performed cyclic voltammetry of HER at the SECM tip while measuring SERS spectra every 200 ms to highlight the technique’s real-time capabilities. Our results show the capability to sensitively interrogate and trigger chem./electrochem. dynamic surface phenomena. We hope SERS-SECM will provide insight on the link between heterogeneous and homogeneous reactivity at electrochem. interfaces.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Dyes and Pigments called Comparative photodynamic inactivation of bioluminescent E. coli by pyridinium and inverted pyridinium chlorins, Author is Calmeiro, Joana M. D.; Dias, Cristina J.; Ramos, Catarina I. V.; Almeida, Adelaide; Tome, Joao P. C.; Faustino, Maria A. F.; Lourenco, Leandro M. O., which mentions a compound: 4556-23-4, SMILESS is SC1=CC=NC=C1, Molecular C5H5NS, Related Products of 4556-23-4.

Photodynamic inactivation (PDI) is a therapeutic approach in study due to the ability to reduce or completely eliminate the bacterial strains without the development of resistance mechanisms. In this therapeutic methodol. the cationic chlorins (Chls) with pyridinium or inverted pyridinium moieties are one of the photosensitizers exploited in our biol. approaches. In this context, we synthesized and characterized new free-base and zinc(II) complexes of pyridinium or inverted pyridinium Chl derivatives (1b, 2, 2a and 2b, resp.) for the inactivation of Escherichia coli (E. coli). The PDI assay was performed with white light irradiation delivered at a fluence rate of 25 mW cm-2. The obtained results of this study demonstrate high PDI efficiency of the zinc(II) metalated Chl 1b, reaching the detection limit of the bioluminescent method (5.2 log reduction) in 45 min of irradiation

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Science China: Life Sciences called Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells, Author is He, Meng; Lin, Jie; Akakuru, Ozioma Udochukwu; Xu, Xiawei; Li, Yanying; Cao, Yi; Xu, Yanping; Wu, Aiguo, which mentions a compound: 4556-23-4, SMILESS is SC1=CC=NC=C1, Molecular C5H5NS, Product Details of 4556-23-4.

The detection of circulating tumor cells (CTCs) is a crucial tool for early cancer diagnosis, prognosis, and postoperative evaluation. However, detection sensitivity remains a major challenge because CTCs are extremely rare in peripheral blood. To effectively detect CTCs, octahedral Ag2O nanoparticles (NPs) with high dispersibility, good biocompatibility, remarkable surface-enhanced Raman scattering (SERS) enhancement, and obvious enhancement selectivity are designed as an SERS platform. Ag2O NPs with many oxygen vacancy defects are successfully synthesized, which exhibit an ultra-high SERS enhancement factor (1.98×106) for 4-mercaptopyridine mols. The remarkable SERS activity of octahedral Ag2O NPs is derived from the synergistic effect of the surface defect-promoted photo-induced charge transfer (PICT) process and strong vibration coupling resonance in the Ag2O-mol. SERS complex, greatly amplifying the mol. Raman scattering cross-section. The promoted PICT process is confirmed using UV-visible (UV-Vis) absorption spectroscopy, demonstrating that obvious PICT resonance occurs in Ag2O SERS system under visible light. An addnl. growth step of SERS bioprobe is proposed by modifying the Raman signal mols. and functional biol. mols. on Ag2O NPs for CTC detection. The Ag2O-based SERS bioprobe exhibits excellent detection specificity for different cancer cells in rabbit blood. Importantly, the high-sensitivity Ag2O-based SERS bioprobe satisfies the requirement for rare CTC detection in the peripheral blood of cancer patients, and the detection limit can reach 1 cell per mL. To our knowledge, this study is the first time that a semiconductor SERS substrate has been successfully utilized in CTC detection. This work provides new insights into CTC detection and the development of novel semiconductor-based SERS platforms for cancer diagnosis.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4556-23-4, is researched, Molecular C5H5NS, about Fabrication of SERS active Langmuir-Blodgett Film substrate for screening human cancer cell lines: Experimental observations supported by multivariate data analyses, the main research direction is prostate breast cancer Langmuir Blodgett film substrate SERS.Recommanded Product: Pyridine-4-thiol.

This paper reports fabrication of efficient and reproducible Surface Enhance Raman Scattering active substrate through integration of self-assembly and Langmuir-Blodgett technique for the detection of normal and cancerous cell lines associated with prostate and breast cancers. Morphol. of the substrate has been visualized using FESEM and AFM images. In vitro cytotoxicity test was performed to check the biocompatibility of the substrate. SERS sensing ability of the substrate has been tested with the probe 4-Mercaptopyridine mol. The as-prepared substrate has been employed for the first time to detect normal and cancerous cell lines linked with prostate and breast cancers. Multivariate statistical approaches like principal component anal. (PCA) and loading spectra were further explored for segregation and identification of the cancer cells from their normal counterparts. Intriguingly, the peak positions of the loading spectra nearly correspond to the difference SERS spectra between the normal and cancerous cell lines of prostate and breast cancers. To our knowledge, such one to one correspondence between the peak positions of loading and differences in the SERS spectra has been noticed for the first time and can act as a diagnostic platform to identify the biomarkers for cancerous cell lines in the mol. scale.

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Formula: C5H5NS. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Can “”Hot Spots”” Be Stable Enough for Surface-Enhanced Raman Scattering?. Author is Zhu, Mei; Li, Moxia; Su, Mengke; Liu, Jianfang; Liu, Bingwu; Ge, Yongjie; Liu, Honglin; Hu, Jiawen.

Because of the random distribution and nonuniform enhancement of hot spots, surface-enhanced Raman scattering (SERS) usually shows poor spectral reproducibility, which greatly limits its practical applications, especially quant. SERS detection. Here, we report our finding that the instability of hot spots is also a key limiting factor for the poor spectral reproducibility of SERS. We show that hot spots show a stability threshold to the excitation power, duration, and wavelength. During SERS measurement, large spectral fluctuation is observed at or above a threshold power because the laser used reshapes (here, weld) the hot spots, causing a continuous decrease in SERS intensity. The threshold power also differs for different excitation wavelengths because of their different resonance extents with the plasmon of the hot spots. Finally, we show that a random SERS substrate can deliver much improved stable, reproducible SERS signals when lowering the excitation power below the threshold or deliberately removing the more unstable hot spots. These results offer a new understanding to the spectral reproducibility of SERS, greatly facilitating reliable SERS detection and the design of robust hot spots.

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