Category: 4553-07-5

Synthetic Route of 4553-07-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4553-07-5 as follows.

General procedure: To a solution of methyleneindolinone (0.1 mmol, 1equiv) and isocyanide 1a (0.15 mmol, 1.5 equiv) in DCM (0.2 mL) was added catalyst VI (0.01 mmol, 0.1 equiv). The resulting mixture was stirred at room temperature (23 C). After thereaction completed, the mixture was quenched with water (5 mL) and extracted with DCM (2 x 5mL). The combined organic layer was washed with brine and dried over Na2SO4. The solvent was then removed under reduced pressure. The product was afforded by silica gel flash chromatography using gradient elution (EtOAc/Hexane = 1:10 to 1:6).

According to the analysis of related databases, 4553-07-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tan, Bin; Zhang, Xuan; Zhong, Guofu; ARKIVOC; vol. 2014; 3; (2014); p. 124 – 142;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4553-07-5, name is Ethyl 2-cyano-2-phenylacetate, A new synthetic method of this compound is introduced below., HPLC of Formula: C11H11NO2

General procedure: To a solution of methyleneindolinone (0.1 mmol, 1equiv) and isocyanide 1a (0.15 mmol, 1.5 equiv) in DCM (0.2 mL) was added catalyst VI (0.01 mmol, 0.1 equiv). The resulting mixture was stirred at room temperature (23 C). After thereaction completed, the mixture was quenched with water (5 mL) and extracted with DCM (2 x 5mL). The combined organic layer was washed with brine and dried over Na2SO4. The solvent was then removed under reduced pressure. The product was afforded by silica gel flash chromatography using gradient elution (EtOAc/Hexane = 1:10 to 1:6).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Tan, Bin; Zhang, Xuan; Zhong, Guofu; ARKIVOC; vol. 2014; 3; (2014); p. 124 – 142;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4553-07-5 as follows. Formula: C11H11NO2

A slurry of sodium hydride (60% dispersion in mineral oil, 811 mg, 20.2 mmol) in dry THF (170 mL) at 0C was added with ethyl 2-cyano-2-phenylacetate (3.2 g, 16.9 mmol). The resulting mixture was stirred for one hour at 0C before adding methyl iodide (2.87 mL, 30.3 mmol) dropwise and slowly warming the mixture to roomtemperature over 16 hours. The mixture was then quenched with saturated aqueous NH4C1 (100 mL) and EtOAc (200 mL). The layers were separated and the aqueous phase was back-extracted with EtOAc (3 x 50 mL). The combined organic phases were dried (MgSO4), filtered and the solvent was removed in vacuo. The residue was purified by silica gel colunm chromatography, eluting with 10% EtOAc in isohexane to give the titlecompound as a colourless oil (2.2 g, 64%).?H NMR (400 MHz, CDC13): oe 7.55-7.5 1 (m, 2 H), 7.44-7.36 (m, 3 H), 4.26-4.22 (m, 2 H), 1.96 (s, 3 H), 1.25 (t, J = 7.2 Hz, 3 H).

According to the analysis of related databases, 4553-07-5, the application of this compound in the production field has become more and more popular.

Reference of 4553-07-5, The chemical industry reduces the impact on the environment during synthesis 4553-07-5, name is Ethyl 2-cyano-2-phenylacetate, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of methyleneindolinone (0.1 mmol, 1 equiv), and isocyanide (0.15 mmol, 1.5 equiv) in toluene (0.2 mL) was added catalyst VI (0.005 mmol, 0.05 equiv). The resulting mixture was stirred at room temperature (23C). After the reaction completed, the mixture was quenched with water (5 mL) and extracted with ethyl acetate (2 x 5 mL). The combined organic layer was washed with brine and dried over Na2SO4. The solvent was then removed under reduced pressure. The product was afforded by silica gel flash chromatography using gradient elution (EtOAc/Hexane = 1:10 to 1:6).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-cyano-2-phenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tan, Bin; Zhang, Xuan; Zhong, Guofu; ARKIVOC; vol. 2014; 3; (2014); p. 124 – 142;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 4553-07-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4553-07-5, name is Ethyl 2-cyano-2-phenylacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To the suspension of ethyl phenylcyanoacetate (1.0 g, 5.3 mmol) in anhydrous ether (200 mL) was added lithium aluminum hydride at 0 C. The mixture was stirred at 0 C. for 18 h. After adding water (1 equiv.), 15% sodium hydroxide (1 equiv.) and water (3 equiv.) to the above solution, the precipitation was removed by filtration. The filtrate was concentrate to dry by lyophilization. Flash chromatography (Merck Silica gel 60, 70-230 mesh, 0%-10% methanol in methylene chloride (0.1% NH4OH) in 30 min afforded 3-hydroxy-2-phenyl-propylamine (0.16 g, 20%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-cyano-2-phenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chen, Li; Chen, Shaoqing; US2006/4045; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts