Category: 455-18-5

Adding a certain compound to certain chemical reactions, such as: 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-18-5, Computed Properties of C8H4F3N

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-18-5, name: 4-(Trifluoromethyl)benzonitrile

Take a 250 mL three-necked flask and add 100 mL of dry tert-amyl alcohol.Sodium (4.0 g, 100 mmol), 10 mg of ferric chloride, heated to 100 C,The mixture was heated and stirred under a nitrogen atmosphere for about 30 minutes, and the sodium particles were completely dissolved. Cool down to around 50 CThen, 4-trifluoromethylbenzonitrile, Compound 1-1 (11.8 g, 68.6 mmol) was added to the system, and the temperature was raised to 100 C. Diisopropyl succinate, Compound 2 (8 mL, 39.6 mmol), was diluted with 30 mL of tert-amyl alcohol, and the mixture was slowly dropped (2-3 h) into a three-necked flask using a constant pressure dropping funnel. After the addition was completed, the reaction was continued for 3 hours.After the reaction is completed, the reaction mixture is poured into a clean 500 mL beaker and naturally cooled to room temperature. Slowly add glacial acetic acid to the beaker to adjust the pH to neutrality.Out. Filter through a Buchner funnel and wash the filter cake with methanol and water until the filtrate is colorless and transparent.After drying the filter cake, a brick red solid powder, Compound 3-1, is obtained.The yield was 81%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; East China University of Science and Technology; Wang Limin; Yang Qingying; Xu Jie; Li Jun; Han Jianwei; Tian He; (18 pag.)CN109897045; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 455-18-5, A common heterocyclic compound, 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of arylnitrile (2.0 mmol) and WR (1.07 g, 2.0 mmol) in 20 mL of dry toluene was refluxed for 8 h. Upon cooling to 90C 1.0 mL of water was added, the mixture was refluxed for another 1 h. After cooling to room temperature the reaction mixture was concentrated to ca. 5.0 mL and extracted with dichloromethane (20 mL x 3), the combined dichloromethane extracts were dried over MgSO4. The final residue was purified by silica gel chromatography (9 : 1 ethyl acetate /dichloromethane as eluent) to give the compounds 1a-1i.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.

455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H4F3N

Step A (4-Trifluoromethylphenyl)thiocarboxamide To a stirred solution of 25.0 grams (0.146 mole) of 4-(trifluoromethyl)benzonitrile in 190 ml of pyridine was added 14.8 grams (0.146 mole) of triethylamine. During a two hour period, hydrogen sulfide gas was bubbled into the reaction mixture. The reaction mixture was stirred under a dry nitrogen atmosphere for 15 minutes and then was poured into ice-water. The aqueous mixture was extracted with three portions of diethyl ether. The organic extracts were combined and washed in succession with 10% hydrochloric acid, water, and an aqueous, saturated sodium chloride solution. The washed extract was dried over anhydrous sodium sulfate and was filtered. The filtrate was evaporated under reduced pressure to yield 28.3 grams of (4-trifluoromethylphenyl)thiocarboxamide as a solid.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.

Reference of 455-18-5,Some common heterocyclic compound, 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A (4-Trifluoromethylphenyl)thiocarboxamide To a stirred solution of 25.0 grams (0.146 mole) of 4-(trifluoromethyl)benzonitrile in 190 ml of pyridine was added 14.8 grams (0.146 mole) of triethylamine. During a two hour period, hydrogen sulfide gas was bubbled into the reaction mixture. The reaction mixture was stirred under a dry nitrogen atmosphere for 15 minutes and then was poured into ice-water. The aqueous mixture was extracted with three portions of diethyl ether. The organic extracts were combined and washed in succession with 10% hydrochloric acid, water, and an aqueous, saturated sodium chloride solution. The washed extract was dried over anhydrous sodium sulfate and was filtered. The filtrate was evaporated under reduced pressure to yield 28.3 grams of (4-trifluoromethylphenyl)thiocarboxamide as a solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethyl)benzonitrile, its application will become more common.

Electric Literature of 455-18-5,Some common heterocyclic compound, 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[Preparation Example 1] Preparation of Compound III-2a [Show Image][Step H] Selenium powder (3.95 g, 50 mmol) was added to ethanol (50 mL) under nitrogen atmosphere. Then, sodium borohydride (2.02g, 53 mmol) wascautiouslyaddedslowlyfor30minutes (Hydrogen gas was produced.). To the resultant ethanolic sodium hydrogen selenide, 4-(trifluoromethyl)benzonitrile (11.9 g, 70 mmol) and pyridine (8 mL) were added. Then, 2 M hydrochloric acid (25 mL) was slowly added dropwise for 1. 5 hours while refluxing at 80 C. After further stirring for about 30 minutes, the precipitated target compound was filtered and washed with hexane and water. Recrystallization using benzene solvent yielded Compound III-2a (15.1 g, yield: 91 %) as yellow solid. 1H NMR (300 MHz, CDCl3) delta 11.07 (b, 1H), 10.43 (b, 1H), 7.99 (d, 2H, J = 8.5 Hz), 7.77 (d, 2H, J = 8.3 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethyl)benzonitrile, its application will become more common.

Reference:
Patent; SNU R & DB Foundation; EP2540711; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 455-18-5

100 ml of tert-amyl alcohol was placed in a 250 ml three-necked flask, and 4 g of sodium was cut into sodium pellets, and then acatalytic amount of 20-40 mg of ferric chloride was added as a catalyst. Heat to 100 ~ 105 C, the reaction 2 ~ 3h. Thetemperature was lowered to 50 to 60 C, and 68.6 mmol of the compound 2-5 was added, followed by heating to 100 to 105 C.8 ml of a mixture of diisopropyl succinate compound 1 and 40 ml of tert-amyl alcohol was added to a three-necked flask througha constant pressure dropping funnel, and the mixture was 3-5 hours after 2-3 hours. Finally, react for another 4 hours, stop thereaction, pour the reaction product into a beaker, dilute with 100 ml of methanol, add acetic acid to adjust the pH to 7, filter withsuction, wash the filter cake with methanol, take the filter cake, heat and dry, then use N, The N-dimethylformamide is thermallydissolved, cooled and suction filtered, and the filter cake is washed with water and methanol, and the filter cake is taken anddried by heating to obtain the product 3-5.

According to the analysis of related databases, 455-18-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China University of Science and Technology; Lily Group Co., Ltd.; Wang Limin; Li Jun; Xu Jie; Wang Feng; Wang Guifeng; Wei Xiaochuan; Wang Kang; He Yulong; Lv Jinge; Yang Qingying; Zhang Yingning; Xu Meng; Tian He; Chen Lirong; (33 pag.)CN109897043; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 455-18-5, name is 4-(Trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H4F3N

Reaction Scheme 3, Step 1 4-Trifluoromethylphenyl-amidoxime A solution of 4-trifluoromethyl benzonitrile (Avocado 14514, 15 g) in toluene (200 ml) was treated with methanol (15 ml) followed by hydroxylamine hydrochloride (2.25 g) and potassium tert-butoxide (3.52 g). The mixture was heated to 80 C. and treated with further portions of hydroxylamine hydrochloride (1.07 g) and potassium tert-butoxide (3.52 g) after 2, 4 and 6 h. The mixture was stirred for 16 h, and then cooled. The solvents were evaporated and the residue partitioned between water (100 ml) and dichloromethane (200 ml). The aqueous layer was extracted with two further portions of dichloromethane (2*200 ml). The organic solutions were combined, dried (anhydrous magnesium sulphate), filtered and evaporated to give the title compound as a white solid (16.7 g, 93%). Mass spectrum, 215 [M+H]+.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Edlin, Christopher David; Redshaw, Sally; Smith, Ian Edward David; Walter, Daryl Simon; US2003/69276; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

General procedure: To the solution of NaOH (5.93 g, 0.15 mol) in water (20 mL) and ethanol (120 mL), hydroxylamine hydrochloride (10.33 g, 0.15 mol) was added in one portion at room temperature. The resulting mixture was then stirred for 10 min, followed by the addition of 4-substituted cyanobenzene (1, 0.12 mol) and then heated to reflux for 4 h. After cooled to room temperature, the reaction mixture was evaporated in vacuo to remove ethanol. The obtained slurry was dissolved in ethyl acetate and filtered. The filtrate was collected, dried over anhydrous Na2SO4, and then concentrated to give corresponding compound 2, which was used in next step without any purification.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dai, Hong; Chen, Jia; Li, Gang; Ge, Shushan; Shi, Yujun; Fang, Yuan; Ling, Yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 950 – 953;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 455-18-5, name is 4-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 455-18-5

A mixture of 4-trifluoromethylbenzonitrile 10 (0.350 g, 2.04 mmol), hydroxylamine hydrochloride (0.213 g, 3.07 mmol) and triethylamine (0.44 mL, 3.24 mmol) in ethanol (4 mL) was refluxed for 3 h. After the completion of the reaction, the solvent was evaporated the crude residue was dissolved in dichloromethane and washed with water and brine once. The organic layer was dried over magnesium sulfate, filtered and evaporated to give 11 as white solid (0.406 g, 99%); 1H NMR (300 MHz, Chloroform-d): delta 4.88 (br s, 2NH), 7.23 (s, 1H), 7.67 (d, J = 8.1 Hz, 2H), 7.76 (d, J = 8.1 Hz, 2H). The analytical data was consistent with literature data. 22

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 455-18-5, its application will become more common.

Reference:
Article; Teng, Yu-Han Gary; Berger, William T.; Nesbitt, Natasha M.; Kumar, Kunal; Balius, Trent E.; Rizzo, Robert C.; Tonge, Peter J.; Ojima, Iwao; Swaminathan, Subramanyam; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5489 – 5495;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts