Category: 453565-55-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 453565-55-4, name is 5-Fluoroisophthalonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Fluoroisophthalonitrile

5 mmol of 3,6-di-tert-butyl-9-bromocarbazole is dissolved in 2 mL of anhydrous tetrahydrofuran (THF) under a nitrogen gas range.Then add 5 mmol of sodium hydride,The mixture was stirred at room temperature for 30 minutes.Subsequently,Add 1 mmol of 1,3-dicyano-5-fluorobenzene to the reaction flask.Stirring was continued for 1 hour.Finally, 2 mL of cold water was added to the mixture to quench the reaction.After the mixture is cooled to room temperature,Vacuum filtration,The product of the reaction is then purified by column chromatography.The purified product is dried in vacuo to give the final product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kunshan Guoxian Optoelectric Co., Ltd.; Tsinghua University; Duan Lian; Zhang Dongdong; Qiu Yong; Zhao Fei; Liu Song; (39 pag.)CN108264479; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 453565-55-4, The chemical industry reduces the impact on the environment during synthesis 453565-55-4, name is 5-Fluoroisophthalonitrile, I believe this compound will play a more active role in future production and life.

3.00 g (9.03 mmol) of 3,3′-9H-biscarbazole and 4.98 g (36.0 mmol) of potassium carbonate were placed in a 200 ml three-necked flask, and the flask was purged with nitrogen. N, N-Dimethylformamide (78.0 ml) was added to the mixture, and the mixture was stirred at room temperature for 2 hours under a nitrogen stream. After adding 2.93 g (18.0 mmol) of 5-fluoroisophthalonitrile into this mixture, the mixture was stirred at 70 C for 20 hours under a nitrogen atmosphere. After the stirring, the solvent in the mixture was removed by distillation under reduced pressure. After removal, 100 ml of chloroform and 50 ml of water were added to this mixture and stirred. After stirring, the mixture was subjected to suction filtration to obtain a filtrate. The obtained aqueous layer of the filtrate and the organic layer were separated, and the organic layer was washed with water. After washing, magnesium sulfate was added to the organic layer and dried. After drying, the mixture was subjected to suction filtration to obtain a filtrate. The obtained filtrate was concentrated and purified by silica gel column chromatography. As the developing solvent, a mixed solvent of chloroform: ethyl acetate = 10: 1 was used first. The resulting fraction was concentrated, and the resulting solid was recrystallized from a mixed solvent of chloroform and methanol to obtain 0.700 g of a pale orange powdery solid as a target product in a yield of 13.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoroisophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KokuritsuDaigakuHojinKyushuDaigaku; Nippon Steel & Sumikin Kagaku Corporation; Li, Bo; Orita, Akihiro; Miyazaki, Hiroshi; Ohterra, Junjo; Nomura, Hiroko; Adachi, Jihaya; (38 pag.)KR2016/34335; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 453565-55-4,Some common heterocyclic compound, 453565-55-4, name is 5-Fluoroisophthalonitrile, molecular formula is C8H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aryl fluoride (51 a-d) (2.0 mmol), 5-chloro-2-methoxyphenol a (50 a) (0.32 g, 2.0 mmol) or 4-chloro-2-methoxyphenol (50 b) (0.32 g, 2.0 mmol) in DMSO (3.0 mL) and anhydrous K2C03 (0.41 g, 3.0 mmol) was heated at 120 C for 5 h. The mixture was poured into ice water and extracted with EtOAc (3 x 50 mL). The organic layer was sequentially washed with brine (2 x 75 mL), dried over anhydrous Na2S04, and concentrated in vacuo. The residue was purified by column chromatography to give 52 a-e and 36. 5-(5-chloro-2-methoxyphenoxy)isophthalonitrile (52 a): (0.28g, 50%) *H NMR (500 MHz, CDC13) 8 7.59 (d, J= 1.28 Hz, 1H), 7.32 (d, J= 1.32 Hz, 2H), 7.30 – 7.25 (m, 1H), 7.12 (d, J= 2.37 Hz, 1H), 6.99 (d, J= 8.84 Hz, 1H), 3.77 (s, 3H). 13C NMR (126 MHz, CDC13) delta 158.66, 150.14, 128.69, 127.30, 126.07, 123.27, 122.98, 118.60, 118.53, 116.32, 115.01, 113.97, 56.10.

The synthetic route of 453565-55-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; WO2013/56003; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 453565-55-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 453565-55-4, name is 5-Fluoroisophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

5-Morpholinoisophthalonitrile.; A mixture of 5-fluoroisophthalonitrile (1.00 g, 6.84 mmol, 1.0 eq.), morpholine (1192 mul, 13.69 mmol, 2.0 eq.), and DMSO (2.0 ml) was stirred overnight at 500C. The mixture was diluted with 2% aq. HCl (30 ml), the solid was separated by filtration, washed with 2% aq. HCl, water, and dried in HV to give pure target product (white solid, 1.35 g, 92% yield, 99% pure by LCMS – no mass observed). 1H-NMR (DMSO-d6) delta (ppm) 7.69 (s, 3H), 3.71 (m, 4H), 3.28 (m, 4H).

The chemical industry reduces the impact on the environment during synthesis 5-Fluoroisophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; KEMIA, INC.; WO2008/21388; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 453565-55-4, name is 5-Fluoroisophthalonitrile, molecular formula is C8H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 453565-55-4

Example 15 To a solution of 1-(3-hydroxyphenyl)ethanol (69 mg) in 1-methyl-2-pyrrolidinone under a nitrogen atmosphere was added sodium hydride (60% in oil, 44 mg). The mixture was stirred at 20 C. for 10 minutes then 5-fluoroisophthalonitrile (0.161 g) was added and the mixture heated at 100 C. for 0.5 hour then at 150 C. for a further 0.5 hour. The cooled mixture was diluted (ethyl acetate), washed (water), dried over magnesium sulphate, evaporated and purified by dry column chromatography on silica (eluent dichloromethane/isohexane) to yield 1-(3,5-dicyanophenoxy)-3-[1-(3,5-dicyanophenoxy)ethyl]benzene (Compound 89, 84 mg), NMR (300 MHz, CDCl3) 7.56 (1H, t); 7.45-7.38 (2H, m); 7.32 (2H, d); 7.24 (2H, d); 7.22-7.18 (1H, m); 6.98 (1H, t); 6.92 (1H, dd); 5.29 (1H, quartet); 1.66 (3H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 453565-55-4, its application will become more common.

Reference:
Patent; Cornell, Clive; Cramp, Michael Colin; Gingell, Michael; Westaway, Susan; US2003/181334; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts