Category: 4435-14-7

So, Ying Hung et al. published their research in Journal of Organic Chemistry in 1982 | CAS: 4435-14-7

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Synthetic Route of C8H13N

Reactions of acetonitrile in a radiofrequency discharge was written by So, Ying Hung;Bezuk, Steve J.;Miller, Larry L.. And the article was included in Journal of Organic Chemistry in 1982.Synthetic Route of C8H13N This article mentions the following:

MeCN passed through an inductively coupled rf discharge under various conditions of power and flow rate gave, as the principal products EtCN, ethane and HCN. Reaction of mixtures of MeCN and cyclohexane gave the same 3 products and cyanocyclohexylmethane, methylcyclohexane, and cyclohexene. All 6 products can be rationalized by neutral radical reactions. Emission spectroscopy of MeCN plasmas showed the expected CN bands from the excited A2π and B2Σ+ states. Anal. of the peak intensities gave a vibrational temperature of ∼5900 °K and rotational temperature of ∼735 °K for the B2Σ+ state. Lower power, higher pressure, or added ethane diminished the emission intensity but did not change these temperatures Added Ar had no effect up to a mol fraction of Ar of 0.8. The absence of cyanoalkanes from plasmas containing CN and alkyl radicals was observed In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7Synthetic Route of C8H13N).

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Synthetic Route of C8H13N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ji, Yaohui et al. published their research in Organic Letters in 2006 | CAS: 4435-14-7

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 4435-14-7

A high-yielding preparation of β-keto nitriles was written by Ji, Yaohui;Trenkle, William C.;Vowles, James V.. And the article was included in Organic Letters in 2006.HPLC of Formula: 4435-14-7 This article mentions the following:

β-Keto nitriles are important precursors for a wide variety of biol. active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide β-keto nitriles is reported. Thus, reaction of PhCH2CH2CN with PhCO2Et in THF containing EtCMe2OH K salt at room temperature for 10 min gave 95% PhCH2CH(CN)COPh. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7HPLC of Formula: 4435-14-7).

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 4435-14-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ezawa, Masatoshi et al. published their research in European Journal of Organic Chemistry in 2017 | CAS: 4435-14-7

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Synthetic Route of C8H13N

One-Pot Preparation of C1-Homologated Aliphatic Nitriles from Aldehydes through a Wittig Reaction under Metal-Cyanide-Free Conditions was written by Ezawa, Masatoshi;Togo, Hideo. And the article was included in European Journal of Organic Chemistry in 2017.Synthetic Route of C8H13N This article mentions the following:

A one-pot protocol to obtain C1-homologated aliphatic nitriles was achieved by treating aromatic and aliphatic aldehydes with the (methoxymethyl)triphenylphosphonium ylide followed by hydrolysis of the resulting Me vinyl ethers with pTsOH (Ts = para-toluenesulfonyl) and treatment with mol. iodine and aqueous ammonia under metal cyanide free conditions. Neopentyl-type nitriles, which could not be obtained by conventional methods that involved conversion of the neopentyl alc. into a tosylate and treatment with metal cyanide, were successfully obtained by using the present method. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7Synthetic Route of C8H13N).

2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Synthetic Route of C8H13N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Analyzing the synthesis route of 4435-14-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyclohexylacetonitrile, its application will become more common.

Related Products of 4435-14-7,Some common heterocyclic compound, 4435-14-7, name is 2-Cyclohexylacetonitrile, molecular formula is C8H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step (2) Preparation of 4-[(3-Benzofuranyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-Oxide According to Scheme I illustrated by Example 4, 3-benzofuranylacetonitrile was converted to the desired product as beige crystals, m.p. 138.5-140 C. temperature. Cyclohexylacetonitrile (14.7 g, 120 mmol) was added in one portion and the resulting mixture was heated to reflux for 12 hours. The mixture was cooled to room temperature and concentrated to give a yellow solid. The solid was collected by filtration, washed with water, EtOAc/hexane (2:8), and dried in vacuo to give 7.4 g (40%) of the product of sufficient purity for use in the next reaction. NMR (DMSO-d6, 200 MHz): delta 0.85 (m, 2H), 1.10 (m, 3H), 1.64 (m, 6H), 1.80 (d, J=7.0, 2H), 5.25 (br s, 2H), 8.30 (br s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyclohexylacetonitrile, its application will become more common.

Reference:
Patent; American Home Products Corporation; US4895860; (1990); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some tips on 2-Cyclohexylacetonitrile

According to the analysis of related databases, 4435-14-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4435-14-7 as follows. HPLC of Formula: C8H13N

The isopropyl cyclohexylacetimidate hydrochloride used as the starting material was prepared as follows: In a manner analogous to that described in Example 1, from cyclohexylacetonitrile, there was obtained isopropyl cyclohexylacetimidate hydrochloride in the form of a pale pink solid of melting point 108-110 C.

According to the analysis of related databases, 4435-14-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; US5399712; (1995); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Extended knowledge of 4435-14-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyclohexylacetonitrile, other downstream synthetic routes, hurry up and to see.

Application of 4435-14-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4435-14-7, name is 2-Cyclohexylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 0.846 g (8.1 mmol) of hydroxylamine hydrochloride in 1 1 mL of isopropyl alcohol, 1 .499 g (17.8 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25 C to 30 C for 10 – 15 min. 1 .0 g (8.1 mmol) of 2- cyclohexylacetonitrile was added and stirred at 80 C to 85 C for 3 – 4 h. After completion of the reaction, the reaction mixture was cooled to 25 C to 30 C, filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue was chased with 5 mL of toluene to yield the title compound.Yield: 0.6 g (47 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyclohexylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan; WO2011/104680; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

New learning discoveries about 4435-14-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyclohexylacetonitrile, its application will become more common.

4435-14-7,Some common heterocyclic compound, 4435-14-7, name is 2-Cyclohexylacetonitrile, molecular formula is C8H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cyclohexyl acetonitrile (a-1) 18g, 2- chloro-benzoyl cyanide (b-1) It was mixed 24g and dichloromethane 700 mL, and cooled to -10 C..Then, after added dropwise over 70 min titanium tetrachloride 82g at the same temperature, was added dropwise over 2 hours N- methylmorpholine88 g, was stirred at room temperature for 15 hours. The reaction mixture was poured into water, stirred and added with chloroform, and filtered theinsoluble matter. The resulting filtrate the aqueous solution of sodium bicarbonate, washed sequentially with water, and then concentrated. By theresulting concentrate is purified by column to give the trans-1- cyclohexyl-2- (2-chlorophenyl) -1,2-dicyano ethylene (c-1) 18.1g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyclohexylacetonitrile, its application will become more common.

Reference:
Patent; YAMADA CHEMICAL COMPANY LIMITED; HASE, TOMOYUKI; (19 pag.)JP2016/11348; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts