Application of 439117-38-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 439117-38-1 as follows.
Step C. [2-(aminomethyl)-5-chlorophenyl]methanol To LAH (1 M/Et2O, 104.4 ml, 104.4 mmol) in anhydrous THF (300 ml) at0 C. was added methyl 5-chloro-2-cyanobenzoate (9.28 g, 0.512 mmol) maintaining the temperature below 20 C. After one half hour, quenched at 0 C. with water (3.97 ml), NaOH (1N, 11.9 ml, 11.9 mmol) and water (3.97 ml). A precipitate was filtered out and washed with THF. The filtrate was concentrated in vacuo and was used immediately in the next step. H NMR (CDCl3, 400 MHz): delta7.17-7.36 (m, 3 H); 4.60 (s, 2 H); 3.98 (s, 2 H);
According to the analysis of related databases, 439117-38-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Barrow, James C.; Coburn, Craig; Selnick, Harold G.; Ngo, Phung L.; US2002/193398; (2002); A1;,
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