Electric Literature of 4387-31-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4387-31-9, name is 4-Chloro-3-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of NaH (1.95 eq) in DMF (20 ml) are added 5.2 g of 1-butyl-piperidin-4-ol (Preparation 3, step A), the mixture is heated 3 h at 60 C., then 4-chloro-3-methyl-benzonitrile (1 eq) in DMF (20 ml) is added and heating continued for a further 4 h at 90 C. After evaporation to dryness, the residue is redissolved in water, extracted with TBME, the organic layer is washed with a 1 N aqueous solution of NaOH then with an aqueous NaCl solution, dried over MgSO4, filtered and evaporated. 4.5 g of the desired product are isolated after chromatography on silica eluting with a DCM/MeOH/NH4OH mixture (95:5:0.5 v/v/v).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CEREP; US2009/233910; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts