Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4360-47-8, name is Cinnamonitrile, A new synthetic method of this compound is introduced below., Product Details of 4360-47-8
General procedure: t-BuOK (5.66 g, 50.0 mmol) was added to a stirred solution of anhydrousTHF containing an appropriate benzaldehyde derivative (7a-l)(5.00 g, 42.0 mmol) and 2-diethoxyphosphorylacetonitrile (8.10 g, 46.0 mmol) at 0 C for 30 min. Then, the reaction was maintained at25 C for a further 30 min. The mixture was extracted with ethyl acetateand the combined organics were washed with brine, dried over sodiumsulfate, and concentrated to give compounds 8a-l. To a solution of 8a-lin ethyl acetate, 5% Pd/C (0.2 equiv.) was added. The suspension wasfiltered and evaporated. Then, the mixture was maintained at 30 Cunder 1 atm of hydrogen for 1 h. Removal of the solvent by rotaryevaporation gave 9a-l. Under nitrogen protection, BH3·THF (2 mol/L,20.7 mL, 41.4 mmol) was added slowly to a solution of 9a-l (4.12 g,27.6 mmol) in anhydrous THF at room temperature. Then, the reactionwas refluxed at 60 C for 2 h. The mixture was extracted with ethylacetate and the combined organics were washed with brine and driedover sodium sulfate, and concentrated to give compounds 10a-l.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Yi, Ce; Xing, Gang; Wang, Siqi; Li, Xiaoran; Liu, Yichuang; Li, Jinyan; Lin, Bin; Woo, Anthony Yiu-Ho; Zhang, Yuyang; Pan, Li; Cheng, Maosheng; Bioorganic and Medicinal Chemistry; vol. 28; 1; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts