3-(Pyridin-4-yl)benzonitrile(cas: 4350-55-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Formula: C12H8N2
Schofield, Joseph; Derdau, Volker; Atzrodt, Jens; Zane, Patricia; Guo, Zuyu; van Horn, Robert; Czepczor, Valerie; Stoltz, Axelle; Pardon, Magalie published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638》.Formula: C12H8N2 The author mentioned the following in the article:
Replacing hydrogen with deuterium as a means of altering ADME properties of drug mols. has recently enjoyed a renaissance, such that at least two deuterated chem. entities are currently in clin. development. Although most research in this area aims to increase the metabolic stability, and hence half-life of the active species, experience has shown that prediction of the in vivo behavior of deuterated mols. is difficult and depends on multiple factors including the complexity of the metabolic scheme, the enzymes involved and hence the mechanism of the rate-determining step in the biotransformation. In an effort to elucidate some of these factors we examined the metabolic behavior of two mols. from the Sanofi portfolio in a range of in vitro and in vivo systems. Although some key metabolic reactions of the acetylcholine release stimulator HP184 4 were slowed in vitro and in vivo when deuterium was present at the sites of metabolism, this did not translate to an increase in overall metabolic stability. By contrast, the tryptase inhibitor AVE5638 13 was much more metabolically stable in vitro in its deuterated form than when unlabeled. These results indicate that it could be of value to concentrate efforts in this area to mols. which are metabolised by a major pathway that involves enzymes of the amine oxidase family or other low-capacity enzyme families. In the experiment, the researchers used many compounds, for example, 3-(Pyridin-4-yl)benzonitrile(cas: 4350-55-4Formula: C12H8N2)
3-(Pyridin-4-yl)benzonitrile(cas: 4350-55-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Formula: C12H8N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts