Category: 42872-30-0

Zhang, Chuan-Tao published the artcileContinuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran, Quality Control of 42872-30-0, the main research area is diaryl ketone preparation continuous flow green chem; aryl Grignard reagent acyl chloride coupling reaction.

An efficient continuous flow sequential synthesis of diaryl ketones RC(O)R1 (R = C6H5, 4-MeOC6H4, thiophen-2-yl, etc.; R1 = 2-MeC6H4, 3-FC6H4, naphthalen-2-yl, etc.) was achieved by coupling of aryl Grignard reagents RMgBr with acyl chlorides R1C(O)Cl in the bio-derived “”green”” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 h), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour-1.

RSC Advances published new progress about Aromatic acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Quality Control of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Martinkova, Ludmila published the artcileEnantioselectivity of the nitrile hydratase from Rhodococcus equi A4 towards substituted (R,S)-2-arylpropionitriles, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is nitrile hydratase enantioselectivity aryl propionitrile Rhodococcus; nitrilase enantioselectivity arylpropionitrile Rhodococcus.

Rhodococcus equi A4 cells containing a nitrile hydratase and an amidase converted (R,S)-2-(4-methoxyphenyl)-propionitrile into the corresponding (S)-acid (e.e. 87%) and (R)-nitrile (e.e. > 95%) in 49% yield. The same reaction using (R,S)-2-(4-chlorophenyl)-propionitrile gave the (S)-acid (e.e. > 95%) and (R)-nitrile (e.e. 52%) in 20 and 34% yield, resp.

Biotechnology Letters published new progress about Nitriles Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Ying published the artcileAssembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides, Formula: C16H13NO, the main research area is aryl heteroaryl nitrile synthesis; copper catalyzed coupling decarboxylation aryl heteroaryl halide cyanoacetate; C−C cross-coupling; anti-inflammatory drugs; copper; oxalamide ligands; α-(hetero)aryl nitriles.

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and Et cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Addnl., the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted Et cyanoacetates proceeds smoothly at 60°C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls. Thus, e.g., 4-chloroanisole + Et cyanoacetate → 2-(4-methoxyphenyl)acetonitrile (up to 80%).

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent) (and heteroaryl). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kurosawa, Miki B. published the artcileUnified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones, HPLC of Formula: 42872-30-0, the main research area is diarylketone palladium catalyst reduction; diarylmethane preparation; oxomethyldiarene palladium catalyst reduction dimerization; tetraarylethane preparation; triarylmethane preparation.

A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a Friedel-Crafts type alkylation to afford the corresponding multiply arylated alkanes. A variety of diarylketones was converted to multiply arylated alkanes such as diarylmethanes, tetraarylethanes and triarylmethanes by reduction, dimerization and arylation in one pot. Furthermore, a one-pot conversion from arylcarboxylic acids to diarylmethanes and tetraarylethanes and a synthesis of tetraarylmethane and triphenylethane using sequential coupling reactions were also presented.

Chemical Science published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, HPLC of Formula: 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chandrashekhar, Vishwas G. published the artcileNickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis, Quality Control of 42872-30-0, the main research area is amine preparation; nitrile amine hydrogenative coupling nickel catalyzed.

A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.

Science (Washington, DC, United States) published new progress about Coupling reaction (hydrogenative). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Quality Control of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Simon B. published the artcileActivation of Alcohols with Carbon Dioxide: Intermolecular Allylation of Weakly Acidic Pronucleophiles, COA of Formula: C16H13NO, the main research area is nitroalkane allyl alc carbon dioxide palladium allylation catalyst; nitrile allyl alc carbon dioxide palladium allylation catalyst; aldehyde allyl alc carbon dioxide palladium allylation catalyst; allylated product preparation.

The direct coupling of allyl alcs. with nitroalkanes, nitriles, and aldehydes using catalytic Pd(PPh3)4 has been accomplished via activation of C-OH bonds with CO2. The in situ formation of carbonates from alcs. and CO2 facilitates oxidative addition to Pd to form reactive π-allylpalladium intermediates. In addition, the formation of a strong base activates nucleophiles toward the reaction with the π-allylpalladium electrophile. Overall, this atom economical reaction provides a new C-C bond without the use of an external base and generates water as the only byproduct.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, COA of Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lukeman, Matthew published the artcileCarbanion-mediated photocages: rapid and efficient photorelease with aqueous compatibility, Synthetic Route of 42872-30-0, the main research area is carbanion mediated photocage efficient photorelease aqueous compatibility; ketoprofen derivative photocage photolysis photorelease carboxylic acid alc.

A new photocage is proposed, based on ketoprofen-derived compounds and mediated by carbanions. The new photocage has significant advantages over the widely used o-nitrobenzyl derivatives, including aqueous compatibility, faster photorelease, higher quantum yield, and innocuous byproducts. The photorelease of ibuprofen illustrates the properties of the new photocage.

Journal of the American Chemical Society published new progress about Elimination reaction kinetics (photochem.). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Synthetic Route of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts